| URN | urn:agi-llid:208 |
|---|---|
| Total Entities | 0 |
| Connectivity | 858 |
| Name | Akt2 |
| Description | thymoma viral proto-oncogene 2 |
| Notes | may be involved in phosphatidylinositol 3-kinase (PI3-K) mediated signaling [RGD] |
| GO Molecular Function | transferase activity |
|---|---|
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein kinase C binding | |
| nucleotide binding | |
| ATP binding |
| GO Cellular Component | membrane |
|---|---|
| ruffle membrane | |
| nucleoplasm | |
| plasma membrane | |
| cytoplasm | |
| cell cortex | |
| cytosol | |
| insulin-responsive compartment | |
| intracellular membrane-bounded organelle | |
| nucleus | |
| lamellipodium | |
| vesicle |
| GO Biological Process | glycogen biosynthetic process |
|---|---|
| positive regulation of glycogen biosynthetic process | |
| regulation of JNK cascade | |
| positive regulation of fatty acid beta-oxidation | |
| activation of Ral GTPase activity | |
| glycogen metabolic process | |
| glucose metabolic process | |
| positive regulation of glucose metabolic process | |
| multicellular organismal development | |
| peripheral nervous system myelin maintenance | |
| mammary gland epithelial cell differentiation | |
| fat cell differentiation | |
| positive regulation of vesicle fusion | |
| regulation of cell cycle arrest | |
| signal transduction | |
| positive regulation of signal transduction | |
| protein kinase B signaling | |
| insulin receptor signaling pathway | |
| negative regulation of plasma membrane long-chain fatty acid transport | |
| intracellular protein transmembrane transport | |
| positive regulation of cell motility | |
| positive regulation of cell migration | |
| regulation of cell migration | |
| apoptotic process | |
| negative regulation of apoptotic process | |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| positive regulation of glucose import in response to insulin stimulus | |
| protein localization to plasma membrane | |
| positive regulation of protein targeting to membrane | |
| carbohydrate transport | |
| positive regulation of sodium ion transport | |
| positive regulation of glucose import | |
| response to insulin | |
| cellular response to insulin stimulus | |
| cellular response to hormone stimulus | |
| cellular response to organic cyclic compound | |
| positive regulation of positive chemotaxis | |
| response to osmotic stress | |
| response to nutrient levels | |
| response to muscle activity | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of gene expression | |
| negative regulation of RNA splicing | |
| regulation of translation | |
| cellular protein modification process | |
| protein phosphorylation | |
| phosphorylation | |
| carbohydrate metabolic process | |
| transport |
| Pathway | Proteins Involved in Pathogenesis of Insulin Resistance |
|---|---|
| Steroid-Induced Cataract | |
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| IGF1R -> MEF/MYOD/MYOG signaling | |
| VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling | |
| VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling | |
| HBEGF/MEF/MYOD Expression Target | |
| NRG1/MEF/MYOD Expression Targets | |
| TGFA/MEF/MYOD/NFATC Expression Targets | |
| IGF2/MEF/MYOD Expression Targets | |
| AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets | |
| AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| insulin responsive facilitative sugar transporter mediated glucose transport pathway | |
| type 2 diabetes mellitus pathway | |
| type 2 diabetes mellitus pathway | |
| pancreatic cancer pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| insulin responsive facilitative sugar transporter mediated glucose transport pathway | |
| type 2 diabetes mellitus pathway | |
| altered insulin responsive facilitative sugar transporter mediated glucose transport pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway |
| Group | AKT |
|---|---|
| Oncogenes | |
| glycogen biosynthetic process | |
| positive regulation of glycogen biosynthetic process | |
| regulation of JNK cascade | |
| positive regulation of fatty acid beta-oxidation | |
| activation of Ral GTPase activity | |
| glycogen metabolic process | |
| glucose metabolic process | |
| positive regulation of glucose metabolic process | |
| multicellular organismal development | |
| peripheral nervous system myelin maintenance | |
| mammary gland epithelial cell differentiation | |
| fat cell differentiation | |
| positive regulation of vesicle fusion | |
| regulation of cell cycle arrest | |
| signal transduction | |
| positive regulation of signal transduction | |
| protein kinase B signaling | |
| insulin receptor signaling pathway | |
| negative regulation of plasma membrane long-chain fatty acid transport | |
| intracellular protein transmembrane transport | |
| positive regulation of cell motility | |
| positive regulation of cell migration | |
| regulation of cell migration | |
| apoptotic process | |
| negative regulation of apoptotic process | |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| positive regulation of glucose import in response to insulin stimulus | |
| protein localization to plasma membrane | |
| positive regulation of protein targeting to membrane | |
| carbohydrate transport | |
| positive regulation of sodium ion transport | |
| positive regulation of glucose import | |
| response to insulin | |
| cellular response to insulin stimulus | |
| cellular response to hormone stimulus | |
| cellular response to organic cyclic compound | |
| positive regulation of positive chemotaxis | |
| response to osmotic stress | |
| response to nutrient levels | |
| response to muscle activity | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of gene expression | |
| negative regulation of RNA splicing | |
| regulation of translation | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| cellular protein modification process | |
| protein phosphorylation | |
| phosphorylation | |
| carbohydrate metabolic process | |
| transport | |
| protein kinase C binding | |
| nucleotide binding | |
| ATP binding | |
| membrane | |
| ruffle membrane | |
| nucleoplasm | |
| plasma membrane | |
| cytoplasm | |
| cell cortex | |
| cytosol | |
| insulin-responsive compartment | |
| intracellular membrane-bounded organelle | |
| nucleus | |
| lamellipodium | |
| vesicle |
| LocusLink ID | 208 |
|---|---|
| 11652 | |
| 25233 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Cell membrane |
| GO ID | 0005524 |
|---|---|
| 0016301 | |
| 0004674 | |
| 0032859 | |
| 0006915 | |
| 0008643 | |
| 0006464 | |
| 0032869 | |
| 0045444 | |
| 0006006 | |
| 0005978 | |
| 0008286 | |
| 0065002 | |
| 0060644 | |
| 0010748 | |
| 0032287 | |
| 2000147 | |
| 0032000 | |
| 0046326 | |
| 2001275 | |
| 0010907 | |
| 0045725 | |
| 0001934 | |
| 0090314 | |
| 0031340 | |
| 0072659 | |
| 0046328 | |
| 0071156 | |
| 0030334 | |
| 0006417 | |
| 0007165 | |
| 0005938 | |
| 0005829 | |
| 0030027 | |
| 0005634 | |
| 0005886 | |
| 0032587 | |
| 0000166 | |
| 0005080 | |
| 0004672 | |
| 0016740 | |
| 0016772 | |
| 0005975 | |
| 0071407 | |
| 0005977 | |
| 0007275 | |
| 0033119 | |
| 0043066 | |
| 0043154 | |
| 0016310 | |
| 0030335 | |
| 0010628 | |
| 0045429 | |
| 0033138 | |
| 0050927 | |
| 0009967 | |
| 0010765 | |
| 0045944 | |
| 0043491 | |
| 0006468 | |
| 0006810 | |
| 0005737 | |
| 0032593 | |
| 0043231 | |
| 0016020 | |
| 0031982 | |
| 0032870 | |
| 0032868 | |
| 0014850 | |
| 0031667 | |
| 0006970 | |
| 0005654 | |
| 0005543 | |
| 0005739 | |
| 0070887 | |
| 0005792 | |
| 0005625 | |
| 0005515 |
| Alias | PKBB |
|---|---|
| PRKBB | |
| HIHGHH | |
| PKBBETA | |
| RAC-BETA | |
| RAC-beta serine/threonine-protein kinase | |
| PKB beta | |
| RAC-PK-beta | |
| protein kinase Akt-2 | |
| protein kinase B beta | |
| rac protein kinase beta | |
| murine thymoma viral (v-akt) homolog-2 | |
| PKB | |
| AW554154 | |
| 2410016A19Rik | |
| protein kinase B, beta | |
| RAC-beta serine/threonine protein kinase | |
| AKT2 kinase | |
| thymoma viral proto-oncogene 2 | |
| RAC protein kinase beta RAC-PK beta | |
| murine thymoma viral (v-akt) oncogene homolog 2 | |
| protein kinase B-beta | |
| rac kinase | |
| thymoma viral proto-oncogene II | |
| v-akt murine thymoma viral oncogene homolog II | |
| RIKEN cDNA 2410016A19 gene | |
| v-akt murine thymoma viral oncogene homolog 2 | |
| AKTII | |
| 2410016A19 | |
| MGC14031 | |
| OTTMUSP00000017784 | |
| OTTMUSP00000022681 | |
| Murine thymoma viral (v-akt) oncogene homolog II | |
| OTTMUSP00000017783 | |
| Murine thymoma viral (v-akt) homolog II | |
| OTTMUSP00000017785 | |
| Akt2 | |
| Protein kinase Akt II |
| Mouse chromosome position | 7 15.94 cM |
|---|---|
| 7 6.5 cM |
| OMIM ID | 164731 |
|---|---|
| 125853 | |
| 240900 |
| Rat chromosome position | 1q22 |
|---|
| Hugo ID | 392 |
|---|
| Human chromosome position | 19q13.1-q13.2 |
|---|
| Swiss-Prot Accession | B4DG79 |
|---|---|
| P31751 | |
| Q3TY95 | |
| Q60823 | |
| P47197 | |
| B2RBD8 | |
| Q05BV0 | |
| Q0VAN1 | |
| Q68GC0 | |
| Q0VAN0 | |
| Q6P4H3 | |
| Q8TBE2 | |
| Q8CE74 | |
| Q3HSE5 |
| PIR ID | A46288 |
|---|---|
| JC2438 |
| Unigene ID | Hs.631535 |
|---|---|
| Mm.177194 | |
| Rn.87066 |
| KEGG ID | hsa:208 |
|---|---|
| mmu:11652 | |
| rno:25233 |
| Swiss-Prot ID | AKT2_MOUSE |
|---|---|
| AKT2_HUMAN | |
| AKT2_RAT | |
| Q3TY95_MOUSE |
| EC Number | 2.7.11.1 |
|---|---|
| 2.7.1.- |
| Ensembl ID | ENSG00000105221 |
|---|---|
| ENSP00000375892 | |
| ENST00000392038 | |
| ENSMUSG00000004056 | |
| ENSMUSP00000132141 | |
| ENSMUST00000167435 | |
| ENSMUSP00000052103 | |
| ENSMUST00000051356 | |
| ENSMUSP00000103980 | |
| ENSMUST00000108343 | |
| ENSRNOG00000018677 | |
| ENSRNOP00000025303 | |
| ENSRNOT00000025303 |
| Homologene ID | 48773 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 104874 |
|---|
| RGD ID | 2082 |
|---|
| MedScan ID | 208 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00212846 |
|---|---|
| IPI00012870 | |
| IPI00121335 | |
| IPI00784816 | |
| IPI00440705 | |
| IPI00816059 | |
| IPI00641838 | |
| IPI00790293 | |
| IPI00798192 | |
| IPI00788928 | |
| IPI00797131 | |
| IPI00797722 | |
| IPI00795867 | |
| IPI00794313 | |
| IPI00830259 | |
| IPI00831519 | |
| IPI00830488 | |
| IPI00830166 | |
| IPI00830685 | |
| IPI00754038 | |
| IPI00830607 |