| URN | urn:agi-llid:10000 |
|---|---|
| Total Entities | 0 |
| Connectivity | 301 |
| Name | Akt3 |
| Description | thymoma viral proto-oncogene 3 |
| Notes | kinase that associates with both protein kinase C subspecies and beta gamma subunits of G proteins [RGD] |
| GO Molecular Function | transferase activity |
|---|---|
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein kinase C binding | |
| nucleotide binding | |
| ATP binding |
| GO Cellular Component | membrane |
|---|---|
| nucleoplasm | |
| nucleolus | |
| plasma membrane | |
| cytoplasm | |
| Golgi apparatus | |
| cytosol | |
| nucleus |
| GO Biological Process | signal transduction |
|---|---|
| positive regulation of sodium ion transport | |
| cellular response to insulin stimulus | |
| protein phosphorylation | |
| peptidyl-threonine phosphorylation | |
| peptidyl-serine phosphorylation | |
| phosphorylation | |
| mitochondrial genome maintenance |
| Pathway | Deregulation of Cell Cycle in Melanoma |
|---|---|
| MITF as a Regulator of Melanoma Cell Development | |
| Proteins Involved in Pathogenesis of Melanoma | |
| Melanoma Overview | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway |
| Group | AKT |
|---|---|
| Oncogenes | |
| signal transduction | |
| positive regulation of sodium ion transport | |
| cellular response to insulin stimulus | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein phosphorylation | |
| peptidyl-threonine phosphorylation | |
| peptidyl-serine phosphorylation | |
| phosphorylation | |
| mitochondrial genome maintenance | |
| protein kinase C binding | |
| nucleotide binding | |
| ATP binding | |
| membrane | |
| nucleoplasm | |
| nucleolus | |
| plasma membrane | |
| cytoplasm | |
| Golgi apparatus | |
| cytosol | |
| nucleus | |
| Genes with Mutations Associated with Melanoma |
| LocusLink ID | 10000 |
|---|---|
| 23797 | |
| 29414 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Membrane |
| GO ID | 0005524 |
|---|---|
| 0004672 | |
| 0004674 | |
| 0000002 | |
| 0006468 | |
| 0007165 | |
| 0005794 | |
| 0005737 | |
| 0005730 | |
| 0005634 | |
| 0005886 | |
| 0016301 | |
| 0000166 | |
| 0005080 | |
| 0016740 | |
| 0016772 | |
| 0032869 | |
| 0018105 | |
| 0018107 | |
| 0016310 | |
| 0010765 | |
| 0016020 | |
| 0005829 | |
| 0005654 | |
| 0005515 |
| Alias | MPPH |
|---|---|
| PKBG | |
| PRKBG | |
| STK-2 | |
| PKB-GAMMA | |
| RAC-gamma | |
| RAC-PK-gamma | |
| RAC-gamma serine/threonine-protein kinase | |
| PKB gamma | |
| RAC-gamma serine/threonine protein kinase | |
| v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | |
| Nmf350 | |
| AI851531 | |
| D930002M15Rik | |
| protein kinase Akt-3 | |
| protein kinase B gamma | |
| AKT3 kinase | |
| protein kinase B, gamma | |
| thymoma viral proto-oncogene 3 | |
| v-akt murine thymoma viral oncogene 3 | |
| protein kinase B-gamma | |
| thymoma viral proto-oncogene III | |
| v-akt murine thymoma viral oncogene homolog 3 | |
| v-akt murine thymoma viral oncogene homolog III | |
| D930002M15 | |
| serine threonine protein kinase, Akt-3 | |
| DKFZP434N0250 | |
| Akt3 | |
| Protein kinase Akt III | |
| OTTHUMP00000037911 | |
| OTTMUSP00000022752 | |
| OTTHUMP00000037912 | |
| v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) | |
| expressed sequence AI851531 |
| Mouse chromosome position | 1 |
|---|---|
| 1 H4-H6 |
| OMIM ID | 611223 |
|---|---|
| 603387 |
| Rat chromosome position | 13q24-q26 |
|---|
| Hugo ID | 393 |
|---|
| Human chromosome position | 1q44 |
|---|---|
| 1q43-q44 |
| Swiss-Prot Accession | Q9Y243 |
|---|---|
| Q8C6X4 | |
| Q9WUA6 | |
| Q63484 | |
| Q0VAA6 | |
| Q5VTI1 | |
| Q5VTI2 | |
| Q96QV3 | |
| Q9UFP5 | |
| Q56A86 |
| PIR ID | JC4345 |
|---|---|
| A59380 | |
| T17287 |
| Unigene ID | Hs.498292 |
|---|---|
| Mm.235194 | |
| Rn.10506 |
| KEGG ID | hsa:10000 |
|---|---|
| mmu:23797 | |
| rno:29414 |
| Swiss-Prot ID | AKT3_MOUSE |
|---|---|
| AKT3_RAT | |
| AKT3_HUMAN |
| EC Number | 2.7.11.1 |
|---|
| Ensembl ID | ENSG00000117020 |
|---|---|
| ENSP00000355498 | |
| ENST00000366540 | |
| ENSP00000336943 | |
| ENST00000336199 | |
| ENSMUSG00000019699 | |
| ENSMUSP00000106790 | |
| ENSMUST00000111160 | |
| ENSRNOG00000021497 | |
| ENSRNOP00000054688 | |
| ENSRNOT00000057879 |
| Homologene ID | 55904 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1345147 |
|---|
| RGD ID | 62390 |
|---|
| MedScan ID | 10000 |
|---|