| URN | urn:agi-llid:3636 |
|---|---|
| Connectivity | 144 |
| Name | Inppl1 |
| Description | inositol polyphosphate phosphatase-like 1 |
| Notes | INPPL1 encodes inositol polyphosphate-5 phosphatase-like 1, a protein that in addition to the phosphatase domain contains an SH2 (src-homology domain 2) motif. |
| Pathway | phosphatidylinositol 3-kinase-Akt signaling pathway |
|---|---|
| phosphatidylinositol 3-kinase-Akt signaling pathway |
| GO Molecular Function | hydrolase activity |
|---|---|
| actin binding | |
| SH3 domain binding | |
| SH2 domain binding | |
| phosphatidylinositol-3,4,5-trisphosphate binding | |
| inositol or phosphatidylinositol phosphatase activity | |
| inositol-polyphosphate 5-phosphatase activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| lamellipodium | |
| cytoplasm | |
| cytosol | |
| actin cortical patch | |
| cytoskeleton |
| GO Biological Process | cell adhesion |
|---|---|
| negative regulation of cell proliferation | |
| post-embryonic development | |
| immune response | |
| brain development | |
| negative regulation of neuron projection development | |
| endocytosis | |
| cellular lipid metabolic process | |
| negative regulation of MAP kinase activity | |
| negative regulation of platelet-derived growth factor receptor signaling pathway | |
| negative regulation of insulin-like growth factor receptor signaling pathway | |
| negative regulation of insulin receptor signaling pathway | |
| negative regulation of DNA replication | |
| glucose metabolic process | |
| inositol trisphosphate metabolic process | |
| actin filament organization | |
| response to drug | |
| response to insulin stimulus | |
| negative regulation of gene expression |
| Group | cell adhesion |
|---|---|
| negative regulation of cell proliferation | |
| post-embryonic development | |
| immune response | |
| brain development | |
| negative regulation of neuron projection development | |
| endocytosis | |
| cellular lipid metabolic process | |
| negative regulation of MAP kinase activity | |
| negative regulation of platelet-derived growth factor receptor signaling pathway | |
| negative regulation of insulin-like growth factor receptor signaling pathway | |
| negative regulation of insulin receptor signaling pathway | |
| negative regulation of DNA replication | |
| glucose metabolic process | |
| inositol trisphosphate metabolic process | |
| actin filament organization | |
| response to drug | |
| response to insulin stimulus | |
| negative regulation of gene expression | |
| hydrolase activity | |
| actin binding | |
| SH3 domain binding | |
| SH2 domain binding | |
| phosphatidylinositol-3,4,5-trisphosphate binding | |
| inositol or phosphatidylinositol phosphatase activity | |
| inositol-polyphosphate 5-phosphatase activity | |
| membrane | |
| plasma membrane | |
| lamellipodium | |
| cytoplasm | |
| cytosol | |
| actin cortical patch | |
| cytoskeleton |
| MedScan ID | 3636 |
|---|
| Hugo ID | 6080 |
|---|
| Human chromosome position | 11q23 |
|---|
| LocusLink ID | 3636 |
|---|---|
| 16332 | |
| 65038 |
| Alias | SHIP2 |
|---|---|
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 | |
| SHIP-2 | |
| INPPL-1 | |
| 51C protein | |
| protein 51C | |
| SH2 domain-containing inositol-5'-phosphatase 2 | |
| 51C | |
| ablSH3-binding protein | |
| SH2 domain-containing inositol phosphatase 2 | |
| inositol polyphosphate phosphatase-like protein 1 | |
| SH2-containing inositol phosphatase 2 | |
| inositol polyphosphate phosphatase-like 1 | |
| inositol polyphosphate phosphatase-like I | |
| INPPL I | |
| INPPL1 | |
| SH2-containing inositol phosphatase II | |
| INPPL1s | |
| INPPL Is | |
| 51(C) | |
| 51-C |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600829 |
|---|
| Mouse chromosome position | 7 |
|---|
| GO ID | 0042169 |
|---|---|
| 0017124 | |
| 0003779 | |
| 0016787 | |
| 0004437 | |
| 0004445 | |
| 0005547 | |
| 0007015 | |
| 0007420 | |
| 0007155 | |
| 0044255 | |
| 0006897 | |
| 0006006 | |
| 0032957 | |
| 0008156 | |
| 0043407 | |
| 0008285 | |
| 0010629 | |
| 0046627 | |
| 0043569 | |
| 0010977 | |
| 0010642 | |
| 0009791 | |
| 0042493 | |
| 0032868 | |
| 0030479 | |
| 0005737 | |
| 0005856 | |
| 0005829 | |
| 0030027 | |
| 0005886 | |
| 0016020 | |
| 0006955 | |
| 0005515 | |
| 0008150 | |
| 0006796 | |
| 0005575 | |
| 0003677 | |
| 0007242 | |
| 0006355 | |
| 0005634 |
| Rat chromosome position | 1q32 |
|---|
| Swiss-Prot Accession | O15357 |
|---|---|
| Q6P549 | |
| Q9WVR3 | |
| O08611 | |
| Q0VDX5 | |
| Q80YB9 | |
| Q9JLL7 | |
| Q9R1V2 | |
| B2RTX5 | |
| Q13577 | |
| Q13578 |
| PIR ID | JC5765 |
|---|
| Unigene ID | Hs.523875 |
|---|---|
| Mm.476000 | |
| Rn.42902 | |
| Mm.5028 |
| KEGG ID | hsa:3636 |
|---|---|
| mmu:16332 | |
| rno:65038 |
| EC Number | 3.1.3.56 |
|---|---|
| 3.1.3.n1 |
| Swiss-Prot ID | SHIP2_MOUSE |
|---|---|
| SHIP2_RAT | |
| SHIP2_HUMAN | |
| B2RTX5_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| cytosol | |
| cytoskeleton | |
| actin patch | |
| Membrane |
| IPI ID | IPI00312067 |
|---|---|
| IPI00205291 | |
| IPI00858399 | |
| IPI00016932 | |
| IPI00795687 | |
| IPI00385017 |
| Homologene ID | 1204 |
|---|
| RGD ID | 68396 |
|---|
| MGI ID | 1333787 |
|---|