ProtModification Pdpk1 --+> Akt1

URN	urn:agi-ProtModification:inout-urn:agi-llid:5170:out-urn:agi-llid:207::positive:phosphorylation
References	392
Connectivity	2
Effect	positive
Mechanism	phosphorylation
Original # of References	260

TextRef	info:pmid/18718528#abs:3
PubYear	2008
MedlineTA	Cell Signal
MedLine Reference	18718528:2
Sentence	PKB is phosphorylated at T308 by its activator PDK1.

TextRef	info:pmid/20361045#abs:3
PubYear	2010
MedlineTA	PLoS ONE
MedLine Reference	20361045:2
Sentence	PDK1 in the appropriate context phosphorylates AKT at threonine 308 to activate AKT.
TextMods	68: '(T308) ' -> ''

TextRef	info:pmid/16630125#abs:5
PubYear	2006
MedlineTA	Cancer Sci
MedLine Reference	16630125:4
Sentence	Phosphorylated PDK1 is an activator of Akt by phosphorylating Akt.
CellType	T-Lymphocytes

TextRef	info:pmid/11500365#abs:7
PubYear	2001
MedlineTA	EMBO J
MedLine Reference	11500365:6
Sentence	In contrast, the PIF-binding pocket of PDK1 is not required for the phosphorylation of PKBalpha by PDK1.

TextRef	info:pmid/11006271#abs:12
PubYear	2000
MedlineTA	J Biol Chem
MedLine Reference	11006271:11
Sentence	In addition, activation of PDK1 is sufficient to phosphorylate PKB at Thr(308) in the cytosol.

TextRef	info:pmid/17616749#abs:2
PubYear	2007
MedlineTA	Am J Physiol Heart Circ Physiol
MedLine Reference	17616749:1
Sentence	Phosphorylated (P-)PDK-1 phosphorylates Akt, which phosphorylates endothelial nitric oxide synthase (eNOS).

TextRef	info:pmid/9368760#abs:7
PubYear	1997
MedlineTA	Curr Biol
MedLine Reference	9368760:6
Sentence	Expressed PDK1 and DSTPK61 phosphorylated Thr308 of PKB alpha only in the presence of Ptdlns(3,4,5)P3 or Ptdlns(3,4)P2.

TextRef	info:pmid/12177059#abs:2
PubYear	2002
MedlineTA	J Biol Chem
MedLine Reference	12177059:1
Sentence	In particular, PDK1 plays an important role in regulating the Akt survival pathway by phosphorylating Akt on Thr-308.

TextRef	info:pmid/11896604#abs:2
PubYear	2002
MedlineTA	Oncogene
MedLine Reference	11896604:1
Sentence	In particular, PDK1 plays an important role in the regulation of Akt/PKB survival pathway by phosphorylating Akt on Thr308.

TextRef	info:pmid/17520061#abs:9
PubYear	2007
MedlineTA	Environ Health Perspect
MedLine Reference	17520061:8
Sentence	Consistent with these findings, PDK-1-catalyzed phosphorylation of PKB/Akt(Thr308) and PKB/Akt activity were suppressed in exposed cells.
CellType	Adipocytes

TextRef	info:pmid/17673571#abs:4
PubYear	2007
MedlineTA	Mol Pharmacol
MedLine Reference	17673571:3
Sentence	In three human thyroid cancer cell lines, OSU-03012 inhibited cell proliferation with reduced AKT phosphorylation by PDK1.

TextRef	info:pmid/19402821#abs:4
PubYear	2009
MedlineTA	Biochem J
MedLine Reference	19402821:3
Sentence	Ku-0063794 also inhibited phosphorylation of the T-loop Thr308 residue of Akt phosphorylated by PDK1 (3-phosphoinositide-dependent protein kinase-1).
Tissue	Serum

TextRef	info:pmid/15611161#abs:3
PubYear	2004
MedlineTA	Genetics
MedLine Reference	15611161:2
Sentence	Although PDK1 phosphorylates and activates protein kinase C, PKB, and RSK in vivo, PDK1 regulation of PKA remains controversial.
TextMods	43: 'PKC' -> 'protein kinase C'

TextRef	info:pmid/10601311#abs:5
PubYear	1999
MedlineTA	J Biol Chem
MedLine Reference	10601311:4
Sentence	Interaction with PDK1 interacting fragment converts PDK1 from a form that phosphorylates PKB at Thr-308 alone to a species capable of phosphorylating Ser-473 as well as Thr-308.
TextMods	17: 'PIF ' -> 'PDK1 interacting fragment '

TextRef	info:pmid/11825911#abs:5
PubYear	2002
MedlineTA	J Biol Chem
MedLine Reference	11825911:4
Sentence	The phosphoinositide-dependent kinase PDK1 is known to phosphorylate PKBalpha on Thr(308), although the identity of the kinase responsible for Ser(473) phosphorylation is less clear.
CellType	Blood Platelets

TextRef	info:pmid/18285454#abs:3
PubYear	2008
MedlineTA	Mol Cell Biol
MedLine Reference	18285454:2
Sentence	Here we show that RalGDS, a Ras effector protein that activates Ral GTPases, has a second function that promotes Akt phosphorylation by PDK1 by bringing these two kinases together.

TextRef	info:pmid/11278835#abs:8
PubYear	2001
MedlineTA	J Biol Chem
MedLine Reference	11278835:7
Sentence	These results suggest that epsilonKD inhibits the insulin-induced phosphorylation and activation of Akt by interfering with the ability of PDK1 to phosphorylate Akt.
CellType	Muscle Fibers, Skeletal
Organ	Ovary
Organism	Mesocricetus auratus

TextRef	info:pmid/19166270#abs:5
PubYear	2009
MedlineTA	PLoS Biol
MedLine Reference	19166270:4
Sentence	The maintenance of PKB's inactive state via the interaction of the PH and kinase domains prevents its activation loop to be phosphorylated by its upstream activator, phosphoinositide-dependent protein kinase-1 (PDK1).

TextRef	info:pmid/17599070#abs:1
PubYear	2007
MedlineTA	EMBO J
MedLine Reference	17599070:0
Sentence	Phosphoinositide-dependent kinase l (PDK1) phosphorylates and activates multiple AGC serine kinases, including protein kinase B (PKB), p70Ribosomal S6 kinase (S6K) and p90Ribosomal S6 kinase .
TextMods	191: '(RSK)' -> ''

TextRef	info:pmid/9637919#abs:3
PubYear	1998
MedlineTA	Curr Biol
MedLine Reference	9637919:2
Sentence	It has been proposed that the amount of PKB activated is determined exclusively as a result of its translocation, and that a constitutively active pool of membrane-associated PDK-1 simply phosphorylates all the PKB made available.

TextRef	info:pmid/15210700#abs:2
PubYear	2004
MedlineTA	J Biol Chem
MedLine Reference	15210700:1
Sentence	A critical component of this pathway is 3-phosphoinositide-dependent kinase-1 (PDK-1), a PH domain-containing enzyme that catalyzes the activating phosphorylation for many AGC kinases, including Akt and protein kinase C isozymes.

TextRef	info:pmid/15584861#abs:6
PubYear	2004
MedlineTA	Expert Opin Ther Targets
MedLine Reference	15584861:5
Sentence	PtdIns(3,4,5)P(3) recruits kinases such as phosphoinositide-dependent kinase 1, which in turn phosphorylate Akt, which phosphorylates other downstream proteins involved in regulation of apoptosis and cell-cycle progression.
CellType	Epithelial Cells

TextRef	info:pmid/11274160#abs:1
PubYear	2001
MedlineTA	J Biol Chem
MedLine Reference	11274160:0
Sentence	Phospholipid-dependent kinase 1 (PDK 1) is a 3'-phospholipid-responsive serine/threonine kinase that plays a critical role in cell survival by phosphorylating and activating the anti-apoptotic AKT/PKB kinase.

TextRef	info:pmid/19703998#abs:2
PubYear	2009
MedlineTA	Mol Cell Biol
MedLine Reference	19703998:1
Sentence	Growth factor-dependent phosphorylation of threonine 308 (Akt-308) by phosphatidylinositol 3-kinase-dependent PDK1 leads to activation of mammalian target of rapamycin (mTor) complex 1 and stimulation of protein synthesis.
TextMods	185: '(TORC1) ' -> ''

TextRef	info:pmid/17500509#abs:1
PubYear	2007
MedlineTA	Bioconjug Chem
MedLine Reference	17500509:0
Sentence	The serine-threonine protein kinases PDK1 and PKB each contain a pleckstrin homology domain that binds the membrane-bound phosphatidylinositol 3,4,5-triphosphate [PI(3,4,5)P3] second messenger and is required for PDK1-catalyzed phosphorylation and activation of PKB.
TextMods	85: '(PH) ' -> ''

TextRef	info:pmid/9427642#abs:5
PubYear	1998
MedlineTA	Curr Biol
MedLine Reference	9427642:4
Sentence	Whereas PDK1-catalyzed phosphorylation and activation of PKB in vitro was highly dependent on the presence of phosphatidylinositol 3,4,5-trisphosphate (Ptdlns (3,4,5)P3), PDK1 catalyzed rapid phosphorylation and activation of p70 in vitro, independent of the presence of Ptdlns(3,4,5)P3.

TextRef	info:pmid/12147684#abs:1
PubYear	2002
MedlineTA	J Biol Chem
MedLine Reference	12147684:0
Sentence	It is reported that 3-phosphoinositide-dependent protein kinase-1 (PDK-1) is activated in a phosphatidylinositol 3,4,5-trisphosphate-dependent manner and phosphorylates Akt, p70S6 kinase, and atypical protein kinase C , but its function on insulin signaling is still unclear.
TextMods	218: '(PKC)' -> ''

TextRef	info:pmid/11313398#abs:6
PubYear	2001
MedlineTA	J Immunol
MedLine Reference	11313398:5
Sentence	In wt-ITAM cells, PDK1 and serine-phosphorylated PKBalpha translocated to lysosomal-associated membrane glycoprotein 1- and cathepsin B-containing vesicles, consistent with MHC class II peptide-loading compartments described by other groups.
CellLineName	IIA1.6
TextMods	215: '(MIIC) ' -> ''
CellType	B-Lymphocytes

TextRef	info:pmid/17407381#abs:7
PubYear	2007
MedlineTA	PLoS Biol
MedLine Reference	17407381:6
Sentence	Physiologically, agonist-induced phosphorylation of PKB by PDK1 occurs coincident to plasma membrane recruitment, and we further shown here that this process is associated with a conformational change in PKB at the membrane, producing a "pleckstrin homology-out" conformer and enabling PDK1 access the activation loop.
TextMods	238: 'PH' -> 'pleckstrin homology'

TextRef	info:pmid/17826953#abs:2
PubYear	2007
MedlineTA	Cell Signal
MedLine Reference	17826953:1
Sentence	In Jurkat cells, PKB/Akt is constitutively active and phosphorylated at the activation-loop residue (Thr308). 3'-phosphoinositide-dependent protein kinase-1 (PDK-1), an enzyme that also contains a PH domain, is thought to catalyse Thr308 phosphorylation of PKB/Akt in addition to other kinase families such as PKC isoforms.
CellLineName	JURKAT

TextRef	info:pmid/9768361#abs:3
PubYear	1998
MedlineTA	Curr Biol
MedLine Reference	9768361:2
Sentence	Recent reports have also shown that the phosphoinositide-dependent protein kinase-1 (PDK-1), which binds with high affinity to the phosphoinositide 3-kinase lipid product phosphatidylinositol-3,4,5-trisphosphate (Ptdins-3,4,5-P3), phosphorylates and potently activates two other phosphoinositide 3-kinase targets, the protein kinases Akt/PKB and p70S6K.
TextMods	131: 'PI 3-kinase ' -> 'phosphoinositide 3-kinase ' 279: 'PI 3-kinase ' -> 'phosphoinositide 3-kinase '

TextRef	info:pmid/10226025#abs:6
PubYear	1999
MedlineTA	Curr Biol
MedLine Reference	10226025:5
Sentence	Remarkably, interaction of PDK1 with PDK1-interacting fragment, or with a synthetic peptide encompassing the PDK2 consensus sequence of PDK1-interacting fragment, converted PDK1 from an enzyme that could phosphorylate only Thr308 of PKBalpha to one that phosphorylates both Thr308 and Ser473 of PKBalpha in a manner dependent on phosphatidylinositol (3,4,5) trisphosphate (PtdIns(3,4,5)P3).
TextMods	37: 'PIF' -> 'PDK1-interacting fragment' 136: 'PIF' -> 'PDK1-interacting fragment'

TextRef	info:pmid/20186153#abs:2
PubYear	2010
MedlineTA	Cell Death Differ
MedLine Reference	20186153:1
Sentence	Previous studies have shown that AKT activation is achieved through a series of phosphorylation steps: first, AKT is phosphorylated at Thr-450 by JNK kinases to prime its activation; then, phosphoinositide-dependent kinase 1 phosphorylates AKT at Thr-308 to expose the Ser-473 residue; and finally, AKT is phosphorylated at Ser-473 by several kinases (PKD2 and others) to achieve its full activation.

TextRef	info:pmid/20051961#abs:6
PubYear	2010
MedlineTA	Br J Cancer
MedLine Reference	20051961:5
Sentence	The derivative 2-O-benzyl-myo-inositol 1,3,4,5,6-pentakisphosphate (2-O-Bn-InsP(5)) is active towards cancer types resistant to InsP(5) in vitro and in vivo. 2-O-Bn-InsP(5) possesses higher pro-apoptotic activity than InsP(5) in sensitive cells and enhances the effect of anti-cancer compounds. 2-O-Bn-InsP(5) specifically inhibits 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vitro (IC(50) in the low nanomolar range) and the PDK1-dependent phosphorylation of Akt in cell lines and excised tumours.

TextRef	info:pmid/9094314#body:220
PubYear	1997
MedlineTA	Curr Biol
MedLine Reference	9094314:1219
Sentence	PDK1 phosphorylates Thr308 of PKBα.

TextRef	info:pmid/12193457#body:42
PubYear	2002
MedlineTA	Circ Res
MedLine Reference	12193457:1041
Sentence	PDK-1 and PDK-2 phosphorylate Akt.

TextRef	info:pmid/17363507#body:74
PubYear	2007
MedlineTA	Mol Cancer Ther
MedLine Reference	17363507:1073
Sentence	PDK1 subsequently phosphorylates and activates AKT.

TextRef	info:pmid/19429855#body:210
PubYear	2009
MedlineTA	Exp Biol Med (Maywood)
MedLine Reference	19429855:1209
Sentence	This results in PDK1 activation which phosphorylates AKT.

TextRef	info:pmid/10983986#body:210
PubYear	2000
MedlineTA	Mol Cell
MedLine Reference	10983986:1209
Sentence	PDK1 phosphorylates Akt on Thr-308 (Stephens et al. 1998).

TextRef	info:pmid/15026550#body:232
PubYear	2004
MedlineTA	Mol Cancer Ther
MedLine Reference	15026550:1231
Sentence	At the membrane, Akt is phosphorylated on Thr 308 by PDK1.

TextRef	info:pmid/12150915#body:113
PubYear	2002
MedlineTA	Mol Cell
MedLine Reference	12150915:1112
Sentence	PDK1 then phosphorylates and activates Akt (Alessi et al., 1997).

TextRef	info:pmid/12824184#body:269
MedLine Reference	12824184:1268
Sentence	PDK1 phosphorylates and activates Akt.

TextRef	info:pmid/16823473#body:80
PubYear	2006
MedlineTA	J Clin Invest
MedLine Reference	16823473:1079
Sentence	AKT is readily phosphorylated and activated by PDK1.
CellType	Neurons

TextRef	info:pmid/12510059#body:322
MedLine Reference	12510059:1321
Sentence	We first overexpressed PDK1 , the upstream activator of the Akt pathway.

TextRef	info:pmid/14604990#body:267
PubYear	2004
MedlineTA	J Biol Chem
MedLine Reference	14604990:1266
Sentence	PDK1 is known to phosphorylate Akt and SGK1 in the activation loop.

TextRef	info:pmid/16306447#body:164
PubYear	2006
MedlineTA	Circ Res
MedLine Reference	16306447:1163
Sentence	Bottom arrow identifies Akt (K179M) phosphorylated by PDK1 and JNK1.

TextRef	info:pmid/15792944#body:58
PubYear	2005
MedlineTA	Exp Biol Med (Maywood)
MedLine Reference	15792944:1057
Sentence	Activated PDK-1 then phosphorylates and activates Akt (17).
CellType	Epithelial Cells

TextRef	info:pmid/10891507#body:380
PubYear	2000
MedlineTA	Mol Cell Biol
MedLine Reference	10891507:1379
Sentence	There, PKB is phosphorylated by PDK1 and probably by PDK2 (Fig. 7C).

TextRef	info:pmid/11729190#body:288
MedLine Reference	11729190:1287
Sentence	PDK1/2 is then proposed to stimulate both Akt and PKA .

TextRef	info:pmid/18216329#body:56
PubYear	2008
MedlineTA	J Cell Sci
MedLine Reference	18216329:1055
Sentence	PDK1 phosphorylates and activates AKT, which regulates various cellular processes.

TextRef	info:pmid/11724768#body:311
PubYear	2002
MedlineTA	J Biol Chem
MedLine Reference	11724768:1310
Sentence	Akt is phosphorylated by PDK-1 on Thr-308 in its activation loop.
CellLineName	HepG 2

TextRef	info:pmid/17463161#body:230
PubYear	2007
MedlineTA	Exp Biol Med (Maywood)
MedLine Reference	17463161:1229
Sentence	PDK1 phosphorylates Akt/PKB on Thr308 (29).
Tissue	Adipose tissue
Organ	Abdomen
Organism	Rattus norvegicus

TextRef	info:pmid/18662999#body:354
PubYear	2008
MedlineTA	Mol Cell Biol
MedLine Reference	18662999:1353
Sentence	When stimulated by growth factors, PDK1 phosphorylates and activates Akt.

TextRef	info:pmid/19940154#body:310
PubYear	2009
MedlineTA	J Biol Chem
MedLine Reference	19940154:1309
Sentence	PDK1 phosphorylates Akt1 to partially activate it and prime it for further activation.

TextRef	info:pmid/12446787#body:229
PubYear	2002
MedlineTA	Mol Cell Biol
MedLine Reference	12446787:1228
Sentence	PDK1 was known to phosphorylate Akt at the Thr308 residue (2, 46, 47).
CellLineName	A 549

TextRef	info:pmid/18171992#body:231
PubYear	2007
MedlineTA	Mol Cancer Res
MedLine Reference	18171992:1230
Sentence	Phosphorylation of Akt at Thr308 is catalyzed by PDK-1 (30, 42).
Organ	Skin
Organism	Mus musculus

TextRef	info:pmid/10995457#body:264
PubYear	2000
MedlineTA	Proc Natl Acad Sci U S A
MedLine Reference	10995457:1263
Sentence	PDK1 might phosphorylate Akt at Thr308 by recognizing the consensus sequence 308TFCGT312.

TextRef	info:pmid/10082559#body:142
MedLine Reference	10082559:1141
Sentence	We therefore tested whether PKCeta K/W would interfere with the activation of Akt by PDK-1.

TextRef	info:pmid/17190838#body:61
PubYear	2007
MedlineTA	J Exp Med
MedLine Reference	17190838:1060
Sentence	PDK1 then phosphorylates and activates Akt and protein kinase Cδ.
TextMods	47: 'PKC' -> 'protein kinase C'
CellType	Mast Cells

TextRef	info:pmid/12947395#body:174
PubYear	2003
MedlineTA	Oncogene
MedLine Reference	12947395:1173
Sentence	PDK1 is proposed to phosphorylate and activate AKT, as is SRC (Chen et al., 2001b).

TextRef	info:pmid/10373549#body:61
PubYear	1999
MedlineTA	Mol Cell Biol
MedLine Reference	10373549:1060
Sentence	One such PKB kinase which phosphorylates PKB on threonine 308 has recently been discovered (4).

TextRef	info:pmid/11016662#body:54
PubYear	2000
MedlineTA	Cancer Res
MedLine Reference	11016662:1053
Sentence	The phosphorylation of Akt at Thr308 is catalyzed by ubiquitously expressed PDK1 (10, 11, 12) .

TextRef	info:pmid/15173318#body:53
PubYear	2004
MedlineTA	J Cell Sci
MedLine Reference	15173318:1052
Sentence	PDK1 and an unidentified PDK2 then phosphorylate and activate Akt on or near the membrane.

TextRef	info:pmid/11054117#body:51
PubYear	2000
MedlineTA	Eur J Biochem
MedLine Reference	11054117:1050
Sentence	Recently, it has been shown that PDK1 could also phosphorylate PKB on Ser473 [22].
CellType	Adipocytes

TextRef	info:pmid/12947100#body:277
MedLine Reference	12947100:1276
Sentence	The phosphorylation of Akt was then catalyzed by PDK1 at plasma membrane ( 41 ).

TextRef	info:pmid/20008564#body:193
PubYear	2009
MedlineTA	J Cell Biol
MedLine Reference	20008564:1192
Sentence	In addition, PDK1-dependent phosphorylation of PKB/Akt on Thr308 was also increased.
Tissue	Muscles

TextRef	info:pmid/15509697#body:216
PubYear	2004
MedlineTA	Reproduction
MedLine Reference	15509697:1215
Sentence	PDK-1, in turn, phosphorylates and activates downstream effectors including Akt.
Organ	Blastocyst
Organism	Oryctolagus cuniculus

TextRef	info:pmid/15033918#body:68
PubYear	2004
MedlineTA	Endocrinology
MedLine Reference	15033918:1067
Sentence	Simultaneously, phosphoinositide-dependent kinase 1 (PDK1) phosphorylates Akt on Thr 308.
Organ	Prostate

TextRef	info:pmid/11102805#body:130
PubYear	2000
MedlineTA	Curr Biol
MedLine Reference	11102805:1129
Sentence	In vitro, PDK-1 catalyzes phosphorylation of PKB exclusively on Thr-308 [1, 2, 7 and 8].
CellLineName	U87 MG

TextRef	info:pmid/14585353#body:116
PubYear	2003
MedlineTA	Cancer Cell
MedLine Reference	14585353:1115
Sentence	PDK1 consequently phosphorylates and activates Akt, which in turn regulates a number of downstream targets.

TextRef	info:pmid/15583002#body:284
PubYear	2005
MedlineTA	J Biol Chem
MedLine Reference	15583002:1283
Sentence	At the membrane PDK-1 phosphorylates and activates PKB via phosphorylation at its activation loop site, Thr308.

TextRef	info:pmid/15930273#body:58
PubYear	2005
MedlineTA	Cancer Res
MedLine Reference	15930273:1057
Sentence	PDK1 consequently phosphorylates and activates Akt, which in turn regulates a number of downstream targets (1).

TextRef	info:pmid/11410590#body:274
MedLine Reference	11410590:1273
Sentence	Akt and SGK are similarly activated by PDK1 and modulated by the PI3K pathway ( 40 , 41 ).

TextRef	info:pmid/17971124#body:196
PubYear	2008
MedlineTA	J Neurochem
MedLine Reference	17971124:1195
Sentence	PI3-phosphate subsequently activates PDK-1, which in turn phosphorylates Akt at Thr308.
CellType	Astrocytes

TextRef	info:pmid/16778088#body:177
PubYear	2006
MedlineTA	Mol Cancer Res
MedLine Reference	16778088:1176
Sentence	Akt is phosphorylated by the phosphoinositide-dependent kinase-1, which is activated on PIP3 binding (30).

TextRef	info:pmid/10616902#body:85
PubYear	1999
MedlineTA	Cell Growth Differ
MedLine Reference	10616902:1084
Sentence	Constitutively active P3k induces PDK1- and PDK2-dependent phosphorylation of Akt and thus activates Akt.

TextRef	info:pmid/12950263#body:53
PubYear	2003
MedlineTA	Eur J Biochem
MedLine Reference	12950263:1052
Sentence	Recent studies showed that the activated PDK-1 phosphorylated PKB at both Thr308 and Ser473 under certain conditions [10].

TextRef	info:pmid/17942896#body:60
PubYear	2007
MedlineTA	Cancer Res
MedLine Reference	17942896:1059
Sentence	Then, they meet on the plasma membrane, where the Thr308 residue of Akt is phosphorylated by PDK1 (4).

TextRef	info:pmid/15068796#body:363
PubYear	2004
MedlineTA	Dev Cell
MedLine Reference	15068796:1362
Sentence	PDK-1 phosphorylates AKT-1, AKT-2, and SGK-1 that form a kinase complex to antagonize DAF-16 by direct phosphorylation.

TextRef	info:pmid/10974038#body:43
PubYear	2000
MedlineTA	J Exp Med
MedLine Reference	10974038:1042
Sentence	PDK1 phosphorylates Thr-308 of Akt and PDK2, a putative kinase yet to be cloned (10), phosphorylates Ser-473 of Akt.

TextRef	info:pmid/14500370#body:148
PubYear	2003
MedlineTA	Cancer Res
MedLine Reference	14500370:1147
Sentence	PDK1 phosphorylates Akt1 and PKCalpha at T308 and T496, respectively, to prime catalytic activity.
CellType	Epithelial Cells
Organ	Mammary Gland

TextRef	info:pmid/15271644#body:137
PubYear	2004
MedlineTA	Am J Physiol Endocrinol Metab
MedLine Reference	15271644:1136
Sentence	In the β-cell, PKB-Thr308 is phosphorylated by a PDK-1 that appears to be constitutively active (13).
CellType	Insulin-Secreting Cells

TextRef	info:pmid/16642037#body:59
PubYear	2006
MedlineTA	EMBO J
MedLine Reference	16642037:1058
Sentence	On the other hand, PDK1 may also directly phosphorylate Akt in the nucleus (Kikani et al, 2005).
CellType	Neurons

TextRef	info:pmid/11731414#body:41
PubYear	2001
MedlineTA	Cancer Res
MedLine Reference	11731414:1040
Sentence	Akt is then further activated by the membrane-associated kinase PDK1, which phosphorylates Akt at Thr308 (3) .
Organ	Bone and Bones

TextRef	info:pmid/16237183#body:63
PubYear	2005
MedlineTA	J Neurosci
MedLine Reference	16237183:1062
Sentence	PDK1 may indirectly phosphorylate Akt at Ser473, probably by interacting with an uncharacterized protein PDK2.
Organ	Brain

TextRef	info:pmid/19584261#body:50
PubYear	2009
MedlineTA	Mol Cancer Res
MedLine Reference	19584261:1049
Sentence	Phosphorylation of Akt by PDK-1 enhances the kinase activity of Akt and results in the phosphorylation of downstream targets (7).

TextRef	info:pmid/16337591#body:46
PubYear	2005
MedlineTA	Mol Cell
MedLine Reference	16337591:1045
Sentence	Expressed PDK1 and DSTPK61 phosphorylated Thr308 of PKBα only in the presence of PtdIns(3,4,5)P3 or PtdIns(3,4)P2.

TextRef	info:pmid/10801415#body:63
PubYear	2000
MedlineTA	Curr Biol
MedLine Reference	10801415:1062
Sentence	Expressed PDK1 and DSTPK61 phosphorylated Thr308 of PKBα only in the presence of PtdIns(3,4,5)P3 or PtdIns(3,4)P2.

TextRef	info:pmid/18688045#body:214
PubYear	2008
MedlineTA	Circ Res
MedLine Reference	18688045:1213
Sentence	PDK1 phosphorylates Akt at Thr308,16,17 but the exact kinase responsible for phosphorylating Ser473 remains controversial.
Organ	Heart

TextRef	info:pmid/14585963#body:305
PubYear	2003
MedlineTA	Mol Cell Biol
MedLine Reference	14585963:1304
Sentence	PDK1 is known to phosphorylate Akt on Thr308, thus permitting phosphorylation on Ser473 and activation of Akt (50).
Tissue	Muscle, Smooth, Vascular

TextRef	info:pmid/11875118#body:40
PubYear	2002
MedlineTA	Mol Endocrinol
MedLine Reference	11875118:1039
Sentence	PDK1/2 as well as other kinases phosphorylate and activate PKB in a hierarchial and complex manner (16, 17).
Organ	Endocrine system

TextRef	info:pmid/19531564#body:291
PubYear	2009
MedlineTA	Mol Cancer Res
MedLine Reference	19531564:1290
Sentence	PDK1 phosphorylates Akt at Thr308, which undergoes a conformational change to allow for further activation by phosphorylation at Ser473 (51).

TextRef	info:pmid/17179391#body:205
PubYear	2007
MedlineTA	Am J Physiol Endocrinol Metab
MedLine Reference	17179391:1204
Sentence	PIP3 and PIP2 activate phosphoinositide-dependent protein kinase-1 (PDK1), which phosphorylates Akt.
CellType	Neurons

TextRef	info:pmid/11376107#body:47
PubYear	2001
MedlineTA	Mol Endocrinol
MedLine Reference	11376107:1046
Sentence	Akt is then phosphorylated by phosphatidylinositol-dependent kinase 1 (PDK1), which has been shown to phosphorylate Thr308 (21, 22).

TextRef	info:pmid/15743829#body:53
PubYear	2005
MedlineTA	Mol Cell Biol
MedLine Reference	15743829:1052
Sentence	When localized to the plasma membrane, but not other cell compartments, PDK1 is able to phosphorylate PKB efficiently (4, 38).

TextRef	info:pmid/16338928#body:261
PubYear	2006
MedlineTA	J Biol Chem
MedLine Reference	16338928:1260
Sentence	Once the activation loop is exposed, PDK1, a constitutively active protein kinase, is available to phosphorylate Akt on Thr-308.
CellType	Keratinocytes

TextRef	info:pmid/15494547#body:333
PubYear	2005
MedlineTA	Am J Physiol Renal Physiol
MedLine Reference	15494547:1332
Sentence	In turn, PDK1 phosphorylates and activates downstream effectors, including Akt (49) and atypical PKC-λ and -ζ isoforms (4, 29, 33, 47).

TextRef	info:pmid/19019920#body:275
PubYear	2009
MedlineTA	Am J Physiol Renal Physiol
MedLine Reference	19019920:1274
Sentence	The kinase PDK1 phosphorylates Akt at Thr308, whereas a "PDK2"-like factor promotes the phosphorylation at Ser473 (15).
CellType	Podocytes

TextRef	info:pmid/15385964#body:54
PubYear	2004
MedlineTA	EMBO J
MedLine Reference	15385964:1053
Sentence	At the plasma membrane, Akt is phosphorylated by the protein kinases PDK1 and PDK2 (Brunet et al, 2001).
CellType	Neurons

TextRef	info:pmid/17341655#body:72
PubYear	2007
MedlineTA	Carcinogenesis
MedLine Reference	17341655:1071
Sentence	Activated PDK1 phosphorylates AKT at thr308 activating its serine-threonine kinase activity (100-fold over the basal).
CellType	Embryonic Stem Cells
Organism	Homo sapiens

TextRef	info:pmid/11724768#body:278
MedLine Reference	11724768:1277
Sentence	Akt is phosphorylated by PDK-1 on Thr-308 in its activation loop.
CellLineName	HepG 2
Journal	J. Biol. Chem
Journal Reference	v277 i7 p5667 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/7/5667
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12376318#body:312
MedLine Reference	12376318:1311
Sentence	Therefore, potentially, the ability of PDK1 to phosphorylate PKB and S6K1 could be differentially regulated.
Tissue	Skeletal muscle
Journal	Endocrin. Metabol
Journal Reference	v283 i5 pE917 (2002)
Journal Link	http://ajpendo.physiology.org/cgi/content/full/283/5/E917
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12738763#body:33
MedLine Reference	12738763:1032
Sentence	Activation of Akt/PKB is regulated by the phosphorylation of T308 and S473 residues by phosphoinositide-dependent kinase 1 (PDK1) and PDK2, respectively ( 19 ).
Tissue	egg
Organ	gastric
Journal	Mol. Endocrin
Journal Reference	v17 i7 p1382 (2003)
Journal Link	http://mend.endojournals.org/cgi/content/full/17/7/1382
Source	Ariadne Signaling Pathways

TextRef	info:pmid/15367694#body:251
MedLine Reference	15367694:1250
Sentence	PDK-1 is a PI 3-kinase-dependent serine/threonine kinase which is upstream of Akt and PKC lambda, and the ability of PDK-1 to phosphorylate and activate Akt and PKC lambda has been extensively studied ( 13 , 14 , 16 , 17 ).
Journal	Mol. Cell. Biol
Journal Reference	v24 i19 p8778 (2004)
Journal Link	http://mcb.asm.org/cgi/content/full/24/19/8778
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12147684#body:35
MedLine Reference	12147684:1034
Sentence	However, very recently, it was reported that the overexpression of only constitutively active mutant PDK-1Ala 280 -Val but not wild type PDK-1 was able to phosphorylate Akt at Thr 308 to the same extent as that stimulated by insulin ( 16 ).
CellType	adipocyte
Journal	J. Biol. Chem
Journal Reference	v277 i41 p38863 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/41/38863
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12972548#body:27
MedLine Reference	12972548:1026
Sentence	PDK1 also phosphorylates PKB as well as atypical protein kinase C isoforms zeta and lambda (PKCeta/lambda) and evidence has been presented both for and against either PKB or PKCeta/lambda as the critical target necessary for insulin-stimulated glucose uptake (Kohn et al., 1996 ; Alessi et al., 1997 ; Bandyopadhyay et al., 1997 ; Le Good et al., 1998 ; Imamura et al., 1999 ; Standaert et al., 1999 ; Wang et al., 1999 ; Kristiansen et al., 2001 ; Matsumoto et al., 2001 ; Yamada et al., 2002 ).
Tissue	Skeletal muscle
Journal	Mol. Biol. Cell
Journal Reference	v14 i9 p3578 (2003)
Journal Link	http://www.molbiolcell.org/cgi/content/full/14/9/3578
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12063287#body:267
MedLine Reference	12063287:1266
Source	Ariadne Signaling Pathways

TextRef	info:pmid/15277520#body:251
MedLine Reference	15277520:1250
Source	Ariadne Signaling Pathways

TextRef	info:pmid/15191648#abs:7
MedLine Reference	15191648:6
Source	Ariadne Signaling Pathways

TextRef	info:pmid/9512493#abs:2
MedLine Reference	9512493:1
Source	Ariadne Signaling Pathways

TextRef	info:pmid/9637919#abs:2
MedLine Reference	9637919:1
Source	Ariadne Signaling Pathways

TextRef	info:pmid/10698680#abs:4
MedLine Reference	10698680:3
Source	Ariadne Signaling Pathways

MedLine Reference	2656608758
Source	Ariadne Signaling Pathways

TextRef	info:pmid/10480933#body:328
MedLine Reference	10480933:1327
Journal	J. Biol. Chem
Journal Reference	v274 i38 p27168 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/38/27168
Source	Ariadne Signaling Pathways

TextRef	info:pmid/11574400#body:210
MedLine Reference	11574400:1209
Tissue	Skeletal muscle
Journal	Diabetes
Journal Reference	v50 i10 p2210 (2001)
Journal Link	http://diabetes.diabetesjournals.org/cgi/content/full/50/10/2210
Source	Ariadne Signaling Pathways

TextRef	info:pmid/11686294#body:41
MedLine Reference	11686294:1040
Journal	Cell Sci
Journal Reference	v114 i16 p2903 (1997)
Journal Link	http://jcs.biologists.org/cgi/content/full/114/16/2903
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12235283#body:81
MedLine Reference	12235283:1080
Journal	Cell Sci
Journal Reference	v115 i19 p3729 (1997)
Journal Link	http://jcs.biologists.org/cgi/content/full/115/19/3729
Source	Ariadne Signaling Pathways

TextRef	info:pmid/11980660#body:233
MedLine Reference	11980660:1232
Journal	Cancer Res
Journal Reference	v62 i9 p2630 (2002)
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/62/9/2630
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12923190#body:29
MedLine Reference	12923190:1028
Journal	J. Biol. Chem
Journal Reference	v278 i44 p42913 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/44/42913
Source	Ariadne Signaling Pathways

TextRef	info:pmid/11297505#body:229
MedLine Reference	11297505:1228
Journal	Genes & Dev
Journal Reference	v15 i7 p807 (2001)
Journal Link	http://www.genesdev.org/cgi/content/full/15/7/807
Source	Ariadne Signaling Pathways

TextRef	info:pmid/10958682#body:23
MedLine Reference	10958682:1022
Journal	Mol. Cell. Biol
Journal Reference	v20 i18 p6860 (2000)
Journal Link	http://mcb.asm.org/cgi/content/full/20/18/6860
Source	Ariadne Signaling Pathways

TextRef	info:pmid/11486023#body:51
MedLine Reference	11486023:1050
Journal	Mol. Cell. Biol
Journal Reference	v21 i17 p5846 (2001)
Journal Link	http://mcb.asm.org/cgi/content/full/21/17/5846
Source	Ariadne Signaling Pathways

TextRef	info:pmid/11559746#body:170
MedLine Reference	11559746:1169
Journal	Cell Sci
Journal Reference	v114 i13 p2375 (1997)
Journal Link	http://jcs.biologists.org/cgi/content/full/114/13/2375
Source	Ariadne Signaling Pathways

TextRef	info:pmid/13130092#body:231
MedLine Reference	13130092:1230
Journal	Cell Sci
Journal Reference	v116 i21 p4409 (1997)
Journal Link	http://jcs.biologists.org/cgi/content/full/116/21/4409
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12163490#body:122
MedLine Reference	12163490:1121
CellType	myocyte
Journal	J. Biol. Chem
Journal Reference	v277 i40 p37670 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/40/37670
Source	Ariadne Signaling Pathways

TextRef	info:pmid/11483613#body:185
MedLine Reference	11483613:1184
CellLineName	BaF3/EpoR
Journal	J. Biol. Chem
Journal Reference	v276 i42 p38518 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/42/38518
Source	Ariadne Signaling Pathways

TextRef	info:pmid/11274216#body:277
MedLine Reference	11274216:1276
CellLineName	INS-1 cell
Journal	J. Biol. Chem
Journal Reference	v276 i24 p21110 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/24/21110
Source	Ariadne Signaling Pathways

TextRef	info:pmid/11358816#body:354
MedLine Reference	11358816:1353
CellLineName	NSCLC
Journal	Cancer Res
Journal Reference	v61 i10 p3986 (2001)
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/61/10/3986
Source	Ariadne Signaling Pathways

TextRef	info:pmid/15201286#body:105
MedLine Reference	15201286:1104
Tissue	retina
Organ	Liver
Journal	J. Biol. Chem
Journal Reference	v279 i36 p37997 (2004)
Journal Link	http://www.jbc.org/cgi/content/full/279/36/37997
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12626520#body:33
MedLine Reference	12626520:1032
Journal	J. Biol. Chem
Journal Reference	v278 i20 p17810 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/20/17810
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12947100#body:280
MedLine Reference	12947100:1279
Journal	J. Biol. Chem
Journal Reference	v278 i45 p44265 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/45/44265
Source	Ariadne Signaling Pathways

TextRef	info:pmid/11060301#body:43
MedLine Reference	11060301:1042
Journal	J. Biol. Chem
Journal Reference	v276 i4 p2395 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/4/2395
Source	Ariadne Signaling Pathways

TextRef	info:pmid/11278423#body:256
MedLine Reference	11278423:1255
Journal	J. Biol. Chem
Journal Reference	v276 i17 p13838 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/17/13838
Source	Ariadne Signaling Pathways

TextRef	info:pmid/11410590#body:275
MedLine Reference	11410590:1274
Journal	J. Biol. Chem
Journal Reference	v276 i34 p31620 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/34/31620
Source	Ariadne Signaling Pathways

TextRef	info:pmid/10935551#body:281
MedLine Reference	10935551:1280
CellType	granulosa
Journal	Mol. Endocrin
Journal Reference	v14 i8 p1283 (2000)
Journal Link	http://mend.endojournals.org/cgi/content/full/14/8/1283
Source	Ariadne Signaling Pathways

TextRef	info:pmid/10851233#body:34
MedLine Reference	10851233:1033
Journal	J. Biol. Chem
Journal Reference	v275 i34 p25979 (2000)
Journal Link	http://www.jbc.org/cgi/content/full/275/34/25979
Source	Ariadne Signaling Pathways

TextRef	info:pmid/10874027#body:41
MedLine Reference	10874027:1040
Journal	J. Biol. Chem
Journal Reference	v275 i36 p27790 (2000)
Journal Link	http://www.jbc.org/cgi/content/full/275/36/27790
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12707009#body:50
MedLine Reference	12707009:1049
Journal	AJRCMB
Journal Reference	v28 i5 p546 (2003)
Journal Link	http://ajrcmb.atsjournals.org/cgi/content/full/28/5/546
Source	Ariadne Signaling Pathways

TextRef	info:pmid/10567559#body:321
MedLine Reference	10567559:1320
Journal	Mol. Cell. Biol
Journal Reference	v19 i12 p8344 (1999)
Journal Link	http://mcb.asm.org/cgi/content/full/19/12/8344
Source	Ariadne Signaling Pathways

TextRef	info:pmid/10891507#body:358
MedLine Reference	10891507:1357
Journal	Mol. Cell. Biol
Journal Reference	v20 i15 p5712 (2000)
Journal Link	http://mcb.asm.org/cgi/content/full/20/15/5712
Source	Ariadne Signaling Pathways

TextRef	info:pmid/10958689#body:29
MedLine Reference	10958689:1028
CellType	B-cell
Journal	Mol. Cell. Biol
Journal Reference	v20 i18 p6945 (2000)
Journal Link	http://mcb.asm.org/cgi/content/full/20/18/6945
Source	Ariadne Signaling Pathways

TextRef	info:pmid/11839816#body:286
MedLine Reference	11839816:1285
Journal	Mol. Cell. Biol
Journal Reference	v22 i5 p1513 (2002)
Journal Link	http://mcb.asm.org/cgi/content/full/22/5/1513
Source	Ariadne Signaling Pathways

TextRef	info:pmid/11909969#body:33
MedLine Reference	11909969:1032
Journal	Mol. Cell. Biol
Journal Reference	v22 i8 p2799 (2002)
Journal Link	http://mcb.asm.org/cgi/content/full/22/8/2799
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12543789#body:40
MedLine Reference	12543789:1039
Journal	Cancer Res
Journal Reference	v63 i2 p364 (2003)
Journal Link	http://cancerres.aacrjournals.org/cgi/content/full/63/2/364
Source	Ariadne Signaling Pathways

TextRef	info:pmid/10636870#body:308
MedLine Reference	10636870:1307
Journal	J. Biol. Chem
Journal Reference	v275 i3 p1739 (2000)
Journal Link	http://www.jbc.org/cgi/content/full/275/3/1739
Source	Ariadne Signaling Pathways

MedLine Reference	3201089578
Journal	Cell
Journal Reference	v103 i2 p253 (2000)
Journal Link	http://www.cell.com/cgi/content/full/103/2/253
Source	Ariadne Signaling Pathways

MedLine Reference	3930761269
Journal	Cell
Journal Reference	v100 i1 p113 (2000)
Journal Link	http://www.cell.com/cgi/content/full/100/1/113
Source	Ariadne Signaling Pathways

TextRef	info:pmid/14742683#body:220
MedLine Reference	14742683:1219
Tissue	endothelial
Journal	Mol. Pharm
Journal Reference	v65 i2 p407 (2004)
Journal Link	http://molpharm.aspetjournals.org/cgi/content/full/65/2/407
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12217898#body:38
MedLine Reference	12217898:1037
Tissue	Skeletal muscle
Journal	Endocrin. Metabol
Journal Reference	v283 i4 pE799 (2002)
Journal Link	http://ajpendo.physiology.org/cgi/content/full/283/4/E799
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12145277#body:188
MedLine Reference	12145277:1187
CellLineName	TA3/ST
Journal	J. Biol. Chem
Journal Reference	v277 i41 p38013 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/41/38013
Source	Ariadne Signaling Pathways

TextRef	info:pmid/9889195#body:190
MedLine Reference	9889195:1189
CellLineName	SOS
Journal	EMBO
Journal Reference	v18 i2 p386 (1999)
Journal Link	http://embojournal.npgjournals.com/cgi/content/full/18/2/386
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12409306#body:125
MedLine Reference	12409306:1124
CellLineName	HepG 2
Journal	J. Biol. Chem
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Journal Link	http://www.jbc.org/cgi/content/full/278/1/48
Source	Ariadne Signaling Pathways

MedLine Reference	2596534811
Source	Ariadne Signaling Pathways

TextRef	info:pmid/15026550#body:198
MedLine Reference	15026550:1197
Source	Ariadne Signaling Pathways

TextRef	info:pmid/14993219#body:63
MedLine Reference	14993219:1062
Source	Ariadne Signaling Pathways

MedLine Reference	3473438887
Source	Ariadne Signaling Pathways

TextRef	info:pmid/11313365#body:285
MedLine Reference	11313365:1284
Journal	J. Biol. Chem
Journal Reference	v276 i29 p27462 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/29/27462
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12070137#body:39
MedLine Reference	12070137:1038
Journal	J. Biol. Chem
Journal Reference	v277 i36 p32587 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/36/32587
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12138204#body:294
MedLine Reference	12138204:1293
Journal	Mol. Cell. Biol
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Journal Link	http://mcb.asm.org/cgi/content/full/22/16/5962
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12242281#body:29
MedLine Reference	12242281:1028
Journal	Mol. Cell. Biol
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Journal Link	http://mcb.asm.org/cgi/content/full/22/20/7015
Source	Ariadne Signaling Pathways

TextRef	info:pmid/10373554#body:206
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Journal	Mol. Cell. Biol
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Journal Link	http://mcb.asm.org/cgi/content/full/19/7/5061
Source	Ariadne Signaling Pathways

TextRef	info:pmid/10336483#body:197
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Journal	J. Biol. Chem
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Source	Ariadne Signaling Pathways

TextRef	info:pmid/11350959#body:40
MedLine Reference	11350959:1039
Organ	Skin
Journal	J. Biol. Chem
Journal Reference	v276 i27 p25558 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/27/25558
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12516969#body:107
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Journal	Mol. Cancer Ther
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Journal Link	http://mct.aacrjournals.org/cgi/content/full/1/14/1349
Source	Ariadne Signaling Pathways

TextRef	info:pmid/10082558#body:143
MedLine Reference	10082558:1142
Journal	Mol. Cell. Biol
Journal Reference	v19 i4 p2921 (1999)
Journal Link	http://mcb.asm.org/cgi/content/full/19/4/2921
Source	Ariadne Signaling Pathways

TextRef	info:pmid/10688640#body:32
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CellType	leukocyte
Journal	Mol. Cell. Biol
Journal Reference	v20 i6 p1956 (2000)
Journal Link	http://mcb.asm.org/cgi/content/full/20/6/1956
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12869584#body:208
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Journal	Genes & Dev
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TextRef	info:pmid/10085060#body:121
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CellType	B-cell
Journal	J. Biol. Chem
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Journal Link	http://www.jbc.org/cgi/content/full/274/13/8347
Source	Ariadne Signaling Pathways

TextRef	info:pmid/15737995#abs:3
MedLine Reference	15737995:2
Tissue	endothelial
Source	Ariadne Signaling Pathways

TextRef	info:pmid/10601311#body:182
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Journal	J. Biol. Chem
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Journal Link	http://www.jbc.org/cgi/content/full/274/52/37400
Source	Ariadne Signaling Pathways

TextRef	info:pmid/10753910#body:112
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Journal Link	http://www.jbc.org/cgi/content/full/275/15/11064
Source	Ariadne Signaling Pathways

TextRef	info:pmid/11445578#body:202
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Journal	J. Biol. Chem
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Source	Ariadne Signaling Pathways

MedLine Reference	3588128912
Journal	Cell
Journal Reference	v103 i2 p185 (2000)
Journal Link	http://www.cell.com/cgi/content/full/103/2/185
Source	Ariadne Signaling Pathways

MedLine Reference	2362532050
Journal	Cell
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Journal Link	http://www.cell.com/cgi/content/full/103/2/185
Source	Ariadne Signaling Pathways

TextRef	info:pmid/12621049#body:29
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TextRef	info:pmid/10887171#body:275
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TextRef	info:pmid/11054117#body:34
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TextRef	info:pmid/12110540#body:208
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TextRef	info:pmid/11376011#body:292
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Source	Ariadne Signaling Pathways