Elsevier Inc. Nfe2l2 signaling pathway insulin responsive facilitative sugar transporter mediated glucose transport pathway mTOR signaling pathway forkhead class O signaling pathway Pp2a complex Pi3k-Akt cytoplasmic targets Pi3k-Akt nuclear targets P-T308 Pp2a complex ---| Akt1 mTORC2 complex --+> Akt1 Pik3 regulatory subunit Inppl1 ---| PIP3 PIP3 Inppl1 Inpp5d ---| PIP3 Inppl1 ---> PIP3 Inpp5d ---> PIP3 Inpp5d Pten ---| PIP3 Pten cell survival cell growth cell proliferation Pik3 regulatory subunit ---- Pik3ca Pik3ca Pik3 regulatory subunit ---- Pik3cd Pik3cd Pik3 regulatory subunit ---- Pik3cb Pik3cb P-tyrosine ---- Pik3 regulatory subunit P-tyrosine Phlpp2 ---| activated Akt members activated Akt members Phlpp2 Phlpp1 ---| activated Akt members Phlpp1 Pp2a complex ---| activated Akt members Pten ---> PIP3 Akt1 Pdpk1 --+> Akt1 Phlpp2 ---| Akt3 Phlpp2 ---| Akt2 Akt2 Phlpp1 ---| Akt3 Phlpp1 ---| Akt2 Akt3 P-S473 activated Akt members --+> insulin responsive facilitative sugar transporter mediated glucose transport pathway activated Akt members --+> mTOR signaling pathway activated Akt members ---> cell proliferation activated Akt members ---| forkhead class O signaling pathway Pdpk1 activated Akt members ---> cell survival Akt1 ---- PIP3 Akt3 ---- PIP3 Akt2 ---- PIP3 Pik3cb ---> PIP2 Pik3ca ---> PIP3 activated Akt members ---> cell growth receptor tyrosine kinase PIP2 Pik3ca ---> PIP2 Pik3cb ---> PIP3 Pdpk1 ---- PIP3 mTORC2 complex activated Akt members --+> Nfe2l2 signaling pathway