| URN | urn:agi-llid:93100 |
|---|---|
| Total Entities | 0 |
| Connectivity | 17 |
| Name | Naprt1 |
| Description | nicotinate phosphoribosyltransferase domain containing 1 |
| Notes | Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008] |
| GO Molecular Function | ligase activity |
|---|---|
| transferase activity | |
| nicotinate-nucleotide diphosphorylase (carboxylating) activity | |
| nicotinate phosphoribosyltransferase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| Golgi apparatus | |
| cytosol | |
| nucleus |
| GO Biological Process | small molecule metabolic process |
|---|---|
| pyridine nucleotide biosynthetic process | |
| NAD biosynthetic process | |
| nicotinate nucleotide salvage | |
| vitamin metabolic process | |
| water-soluble vitamin metabolic process | |
| nicotinamide metabolic process | |
| NAD metabolic process | |
| response to oxidative stress |
| Pathway | nicotinamide adenine dinucleotide biosynthetic pathway |
|---|
| Group | small molecule metabolic process |
|---|---|
| pyridine nucleotide biosynthetic process | |
| NAD biosynthetic process | |
| nicotinate nucleotide salvage | |
| vitamin metabolic process | |
| water-soluble vitamin metabolic process | |
| nicotinamide metabolic process | |
| NAD metabolic process | |
| response to oxidative stress | |
| ligase activity | |
| transferase activity | |
| nicotinate-nucleotide diphosphorylase (carboxylating) activity | |
| nicotinate phosphoribosyltransferase activity | |
| cytoplasm | |
| Golgi apparatus | |
| cytosol | |
| nucleus |
| LocusLink ID | 93100 |
|---|---|
| 223646 | |
| 315085 |
| Cell Localization | Cytoplasm |
|---|---|
| Cytosol |
| GO ID | 0016874 |
|---|---|
| 0004516 | |
| 0004514 | |
| 0009435 | |
| 0019674 | |
| 0006769 | |
| 0019358 | |
| 0006979 | |
| 0044281 | |
| 0006766 | |
| 0006767 | |
| 0005794 | |
| 0005737 | |
| 0005829 | |
| 0005634 | |
| 0016740 | |
| 0019363 |
| Alias | PP3856 |
|---|---|
| nicotinate phosphoribosyltransferase | |
| NAPRTase | |
| FHA-HIT-interacting protein | |
| nicotinic acid phosphoribosyltransferase | |
| nicotinate phosphoribosyltransferase domain-containing protein 1 | |
| 9130210N20Rik | |
| nicotinate phosphoribosyltransferase-like protein | |
| FHIP | |
| PP-3856 | |
| PP(3856) | |
| OTTHUMP00000211079 | |
| naprt1 | |
| LOC315085 | |
| CG3714-PA | |
| 9130210N20 | |
| CG3714 | |
| nicotinate phosphoribosyltransferase domain containing 1 |
| Mouse chromosome position | 15 |
|---|
| OMIM ID | 611552 |
|---|
| Rat chromosome position | 7q34 |
|---|
| Hugo ID | 30450 |
|---|
| Human chromosome position | 8q24.3 |
|---|
| Swiss-Prot Accession | Q6XQN6 |
|---|---|
| Q8CC86 | |
| Q6XQN1 | |
| Q8C7W2 | |
| A7BFI3 | |
| Q6PJL1 | |
| Q6XQN4 | |
| Q6XQN5 | |
| Q8N5E8 | |
| Q9BRG0 |
| Unigene ID | Hs.493164 |
|---|---|
| Mm.288368 | |
| Rn.22665 |
| KEGG ID | hsa:93100 |
|---|---|
| mmu:223646 | |
| rno:315085 |
| Swiss-Prot ID | PNCB_MOUSE |
|---|---|
| PNCB_RAT | |
| PNCB_HUMAN |
| EC Number | 6.3.4.21 |
|---|
| Ensembl ID | ENSG00000147813 |
|---|---|
| ENSP00000401508 | |
| ENST00000449291 | |
| ENSP00000390949 | |
| ENST00000426292 | |
| ENSMUSG00000022574 | |
| ENSMUSP00000023237 | |
| ENSMUST00000023237 | |
| ENSRNOG00000007939 | |
| ENSRNOP00000010637 | |
| ENSRNOT00000010637 |
| Homologene ID | 82285 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 2442664 |
|---|
| RGD ID | 1302945 |
|---|
| MedScan ID | 93100 |
|---|