| URN | urn:agi-llid:10135 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1033 |
| Name | Nampt |
| Description | nicotinamide phosphoribosyltransferase |
| Notes | This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011] |
| GO Molecular Function | transferase activity |
|---|---|
| transferase activity, transferring glycosyl groups | |
| nicotinamide phosphoribosyltransferase activity | |
| nicotinate-nucleotide diphosphorylase (carboxylating) activity | |
| drug binding | |
| cytokine activity | |
| protein homodimerization activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| nucleus |
| GO Biological Process | female pregnancy |
|---|---|
| small molecule metabolic process | |
| pyridine nucleotide biosynthetic process | |
| NAD biosynthetic process | |
| vitamin metabolic process | |
| water-soluble vitamin metabolic process | |
| nicotinamide metabolic process | |
| NAD metabolic process | |
| adipose tissue development | |
| cell-cell signaling | |
| signal transduction | |
| insulin receptor signaling pathway | |
| positive regulation of cell proliferation | |
| positive regulation of smooth muscle cell proliferation | |
| response to organic cyclic compound | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of nitric-oxide synthase biosynthetic process |
| Pathway | Proteins Involved in Pathogenesis of Diabetes Mellitus Type 2 |
|---|---|
| Proteins Involved in Pathogenesis of Atherosclerosis | |
| Proteins Involved in Pathogenesis of Osteoarthritis | |
| Proteins Involved in Pathogenesis of Polycystic Ovary Syndrome | |
| Proteins Involved in Pathogenesis of Rheumatoid Arthritis | |
| nicotinamide adenine dinucleotide biosynthetic pathway |
| Group | female pregnancy |
|---|---|
| small molecule metabolic process | |
| pyridine nucleotide biosynthetic process | |
| NAD biosynthetic process | |
| vitamin metabolic process | |
| water-soluble vitamin metabolic process | |
| nicotinamide metabolic process | |
| NAD metabolic process | |
| adipose tissue development | |
| cell-cell signaling | |
| signal transduction | |
| insulin receptor signaling pathway | |
| positive regulation of cell proliferation | |
| positive regulation of smooth muscle cell proliferation | |
| response to organic cyclic compound | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of nitric-oxide synthase biosynthetic process | |
| transferase activity | |
| transferase activity, transferring glycosyl groups | |
| nicotinamide phosphoribosyltransferase activity | |
| nicotinate-nucleotide diphosphorylase (carboxylating) activity | |
| drug binding | |
| cytokine activity | |
| protein homodimerization activity | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 10135 |
|---|---|
| 59027 | |
| 297508 |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm | |
| Secreted |
| GO ID | 0005125 |
|---|---|
| 0047280 | |
| 0004514 | |
| 0009435 | |
| 0019674 | |
| 0060612 | |
| 0007267 | |
| 0008286 | |
| 0006769 | |
| 0008284 | |
| 0051770 | |
| 0045944 | |
| 0007165 | |
| 0044281 | |
| 0006766 | |
| 0006767 | |
| 0005829 | |
| 0008144 | |
| 0042803 | |
| 0016740 | |
| 0016757 | |
| 0048661 | |
| 0019363 | |
| 0005737 | |
| 0005634 | |
| 0007565 | |
| 0014070 |
| Alias | VF |
|---|---|
| PBEF | |
| PBEF1 | |
| VISFATIN | |
| 1110035O14Rik | |
| nicotinamide phosphoribosyltransferase | |
| NAmPRTase | |
| pre-B cell-enhancing factor | |
| pre-B-cell colony enhancing factor 1 | |
| pre-B-cell colony-enhancing factor 1 | |
| AI314458 | |
| AI480535 | |
| pre-B-cell colony-enhancing factor 1 homolog | |
| RIKEN cDNA 1110035O14 gene | |
| pre-b-cell colony enhancing factor I | |
| pre-B-cell colony-enhancing factor | |
| naprtases | |
| OTTHUMP00000179150 | |
| naprtase | |
| DKFZp666B131 | |
| h_nh0022n19_gi18089094.sp_cds.1 | |
| MGC117256 | |
| nampt | |
| 1110035O14 |
| Mouse chromosome position | 12 |
|---|
| OMIM ID | 608764 |
|---|
| Rat chromosome position | 6q16 |
|---|
| Hugo ID | 30092 |
|---|
| Human chromosome position | 7q22.3 |
|---|
| Swiss-Prot Accession | P43490 |
|---|---|
| Q99KQ4 | |
| Q80Z29 | |
| Q8C3B5 | |
| Q9JKM0 | |
| Q2VT47 | |
| A4D0Q9 | |
| A4D0R0 | |
| Q3KQV0 | |
| Q8WW95 |
| PIR ID | A55927 |
|---|
| Unigene ID | Hs.489615 |
|---|---|
| Mm.202727 | |
| Rn.203508 |
| KEGG ID | hsa:10135 |
|---|---|
| mmu:59027 | |
| rno:297508 |
| Swiss-Prot ID | NAMPT_MOUSE |
|---|---|
| NAMPT_RAT | |
| NAMPT_HUMAN |
| EC Number | 2.4.2.12 |
|---|
| Ensembl ID | ENSG00000105835 |
|---|---|
| ENSP00000222553 | |
| ENST00000222553 | |
| ENSMUSG00000020572 | |
| ENSMUSP00000020886 | |
| ENSMUST00000020886 | |
| ENSRNOG00000009754 | |
| ENSRNOP00000013043 | |
| ENSRNOT00000013043 |
| Homologene ID | 4201 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1929865 |
|---|
| RGD ID | 631365 |
|---|
| MedScan ID | 10135 |
|---|