| URN | urn:agi-llid:349565 |
|---|---|
| Total Entities | 0 |
| Connectivity | 20 |
| Name | Nmnat3 |
| Description | nicotinamide nucleotide adenylyltransferase 3 |
| Notes | This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] |
| GO Molecular Function | catalytic activity |
|---|---|
| transferase activity | |
| nucleotidyltransferase activity | |
| nicotinamide-nucleotide adenylyltransferase activity | |
| nicotinate-nucleotide adenylyltransferase activity | |
| nucleotide binding | |
| ATP binding |
| GO Cellular Component | cytosol |
|---|---|
| mitochondrion |
| GO Biological Process | small molecule metabolic process |
|---|---|
| pyridine nucleotide biosynthetic process | |
| NAD biosynthetic process | |
| vitamin metabolic process | |
| water-soluble vitamin metabolic process | |
| NAD metabolic process | |
| response to wounding | |
| biosynthetic process |
| Pathway | nicotinamide adenine dinucleotide biosynthetic pathway |
|---|
| Group | NAD biosynthesis |
|---|---|
| small molecule metabolic process | |
| pyridine nucleotide biosynthetic process | |
| NAD biosynthetic process | |
| vitamin metabolic process | |
| water-soluble vitamin metabolic process | |
| NAD metabolic process | |
| response to wounding | |
| biosynthetic process | |
| catalytic activity | |
| transferase activity | |
| nucleotidyltransferase activity | |
| nicotinamide-nucleotide adenylyltransferase activity | |
| nicotinate-nucleotide adenylyltransferase activity | |
| nucleotide binding | |
| ATP binding | |
| cytosol | |
| mitochondrion |
| LocusLink ID | 349565 |
|---|---|
| 74080 |
| Cell Localization | Cytoplasm |
|---|---|
| Mitochondrion |
| GO ID | 0005524 |
|---|---|
| 0000309 | |
| 0004515 | |
| 0009435 | |
| 0019674 | |
| 0009611 | |
| 0044281 | |
| 0006766 | |
| 0006767 | |
| 0005829 | |
| 0005739 | |
| 0003824 | |
| 0000166 | |
| 0016779 | |
| 0016740 | |
| 0009058 | |
| 0019363 |
| Alias | PNAT3 |
|---|---|
| FKSG76 | |
| PNAT-3 | |
| nicotinamide mononucleotide adenylyltransferase 3 | |
| NMN adenylyltransferase 3 | |
| NaMN adenylyltransferase 3 | |
| pyridine nucleotide adenylyltransferase 3 | |
| nicotinate-nucleotide adenylyltransferase 3 | |
| 4933408N02Rik | |
| naMN adenylyltransferase 1 | |
| nicotinate-nucleotide adenylyltransferase 1 | |
| NMNAT3 | |
| pyridine nucleotide adenylyltransferase III | |
| OTTMUSP00000025891 | |
| OTTMUSP00000025890 | |
| nicotinamide nucleotide adenylyltransferase III | |
| nicotinamide nucleotide adenylyltransferase 3 | |
| MGC102340 |
| Mouse chromosome position | 9 |
|---|
| OMIM ID | 608702 |
|---|
| Hugo ID | 20989 |
|---|
| Human chromosome position | 3q23 |
|---|
| Swiss-Prot Accession | Q96T66 |
|---|---|
| Q49AL4 | |
| Q99JR6 | |
| Q58E37 | |
| B3KVR6 | |
| D3DNF2 | |
| D3DNF3 | |
| Q8N4G1 |
| Unigene ID | Hs.208673 |
|---|---|
| Hs.745268 | |
| Mm.294082 |
| KEGG ID | hsa:349565 |
|---|---|
| mmu:74080 |
| Swiss-Prot ID | NMNA3_MOUSE |
|---|---|
| NMNA3_HUMAN |
| EC Number | 2.7.7.18 |
|---|---|
| 2.7.7.1 |
| Ensembl ID | ENSG00000163864 |
|---|---|
| ENSP00000412953 | |
| ENST00000413939 | |
| ENSP00000340523 | |
| ENST00000339837 | |
| ENSMUSG00000032456 | |
| ENSMUSP00000035031 | |
| ENSMUST00000035031 | |
| ENSMUSP00000108560 | |
| ENSMUST00000112938 |
| Homologene ID | 39772 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| MGI ID | 1921330 |
|---|
| RGD ID | 1309140 |
|---|
| MedScan ID | 349565 |
|---|