| URN | urn:agi-llid:23475 |
|---|---|
| Total Entities | 0 |
| Connectivity | 19 |
| Name | Qprt |
| Description | quinolinate phosphoribosyltransferase |
| Notes | This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | catalytic activity |
|---|---|
| transferase activity | |
| transferase activity, transferring glycosyl groups | |
| transferase activity, transferring pentosyl groups | |
| nicotinate-nucleotide diphosphorylase (carboxylating) activity | |
| protein homodimerization activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol |
| GO Biological Process | small molecule metabolic process |
|---|---|
| pyridine nucleotide biosynthetic process | |
| NAD biosynthetic process | |
| quinolinate catabolic process | |
| vitamin metabolic process | |
| quinolinate metabolic process | |
| water-soluble vitamin metabolic process | |
| NAD metabolic process | |
| protein oligomerization |
| Pathway | nicotinamide adenine dinucleotide biosynthetic pathway |
|---|
| Group | NAD biosynthesis |
|---|---|
| small molecule metabolic process | |
| pyridine nucleotide biosynthetic process | |
| NAD biosynthetic process | |
| quinolinate catabolic process | |
| vitamin metabolic process | |
| quinolinate metabolic process | |
| water-soluble vitamin metabolic process | |
| NAD metabolic process | |
| catalytic activity | |
| transferase activity | |
| transferase activity, transferring glycosyl groups | |
| transferase activity, transferring pentosyl groups | |
| nicotinate-nucleotide diphosphorylase (carboxylating) activity | |
| protein oligomerization | |
| protein homodimerization activity | |
| cytoplasm | |
| cytosol |
| LocusLink ID | 23475 |
|---|---|
| 67375 | |
| 293504 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0004514 |
|---|---|
| 0042803 | |
| 0009435 | |
| 0019674 | |
| 0051259 | |
| 0034213 | |
| 0044281 | |
| 0006766 | |
| 0006767 | |
| 0005829 | |
| 0003824 | |
| 0016740 | |
| 0016757 | |
| 0016763 | |
| 0019363 | |
| 0046874 | |
| 0005737 |
| Alias | QPRTase |
|---|---|
| HEL-S-90n | |
| nicotinate-nucleotide pyrophosphorylase [carboxylating] | |
| QAPRTase | |
| epididymis secretory sperm binding protein Li 90n | |
| nicotinate-nucleotide pyrophosphorylase (carboxylating) | |
| AI647766 | |
| 2410027J01Rik | |
| nicotinate-nucleotide pyrophosphorylase | |
| MGC108807 | |
| quinolinic acid phosphoribosyltransferases | |
| quinolinic phosphoribosyltransferase | |
| quinolinic phosphoribosyltransferases | |
| quinolinic acid phosphoribosyltransferase | |
| LOC100912382 | |
| Quinolinate phosphoribosyltransferase | |
| QPRTases | |
| QPRT | |
| 2410027J01 | |
| Quinolinate phosphoribosyltransferase (decarboxylating) |
| Mouse chromosome position | 7 |
|---|
| OMIM ID | 606248 |
|---|
| Rat chromosome position | 1q36 |
|---|
| Hugo ID | 9755 |
|---|
| Human chromosome position | 16p11.2 |
|---|
| Swiss-Prot Accession | Q15274 |
|---|---|
| Q91X91 | |
| Q5I0M2 | |
| Q53XW7 | |
| Q96G22 | |
| Q9BSG6 |
| PIR ID | T46864 |
|---|
| Unigene ID | Hs.513484 |
|---|---|
| Mm.26928 | |
| Rn.9220 |
| KEGG ID | hsa:23475 |
|---|---|
| mmu:67375 | |
| rno:293504 |
| Swiss-Prot ID | NADC_MOUSE |
|---|---|
| NADC_HUMAN | |
| NADC_RAT |
| EC Number | 2.4.2.19 |
|---|
| Ensembl ID | ENSRNOG00000016980 |
|---|---|
| ENSRNOP00000023080 | |
| ENSRNOT00000023080 |
| Homologene ID | 8623 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1914625 |
|---|
| RGD ID | 1310309 |
|---|
| MedScan ID | 23475 |
|---|