| URN | urn:agi-llid:23057 |
|---|---|
| Total Entities | 0 |
| Connectivity | 51 |
| Name | Nmnat2 |
| Description | nicotinamide nucleotide adenylyltransferase 2 |
| Notes | This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | catalytic activity |
|---|---|
| transferase activity | |
| nucleotidyltransferase activity | |
| nicotinamide-nucleotide adenylyltransferase activity | |
| nicotinate-nucleotide adenylyltransferase activity | |
| nucleotide binding | |
| ATP binding |
| GO Cellular Component | synapse |
|---|---|
| Golgi membrane | |
| cytoplasm | |
| Golgi apparatus | |
| late endosome | |
| trans-Golgi network | |
| nucleus |
| GO Biological Process | small molecule metabolic process |
|---|---|
| pyridine nucleotide biosynthetic process | |
| NAD biosynthetic process | |
| vitamin metabolic process | |
| water-soluble vitamin metabolic process | |
| NAD metabolic process | |
| biosynthetic process |
| Pathway | nicotinamide adenine dinucleotide biosynthetic pathway |
|---|
| Group | NAD biosynthesis |
|---|---|
| small molecule metabolic process | |
| pyridine nucleotide biosynthetic process | |
| NAD biosynthetic process | |
| vitamin metabolic process | |
| water-soluble vitamin metabolic process | |
| NAD metabolic process | |
| biosynthetic process | |
| catalytic activity | |
| transferase activity | |
| nucleotidyltransferase activity | |
| nicotinamide-nucleotide adenylyltransferase activity | |
| nicotinate-nucleotide adenylyltransferase activity | |
| nucleotide binding | |
| ATP binding | |
| synapse | |
| Golgi membrane | |
| cytoplasm | |
| Golgi apparatus | |
| late endosome | |
| trans-Golgi network | |
| nucleus |
| LocusLink ID | 23057 |
|---|---|
| 226518 | |
| 289095 |
| Cell Localization | Cytoplasm |
|---|---|
| Golgi apparatus |
| GO ID | 0005524 |
|---|---|
| 0000309 | |
| 0004515 | |
| 0009435 | |
| 0019674 | |
| 0044281 | |
| 0006766 | |
| 0006767 | |
| 0005794 | |
| 0000139 | |
| 0005737 | |
| 0005770 | |
| 0005634 | |
| 0045202 | |
| 0005802 | |
| 0003824 | |
| 0000166 | |
| 0016779 | |
| 0016740 | |
| 0009058 | |
| 0019363 |
| Alias | PNAT2 |
|---|---|
| C1orf15 | |
| RP11-181K3.3 | |
| nicotinamide mononucleotide adenylyltransferase 2 | |
| NMN adenylyltransferase 2 | |
| NaMN adenylyltransferase 2 | |
| pyridine nucleotide adenylyltransferase 2 | |
| nicotinate-nucleotide adenylyltransferase 2 | |
| PNAT1 | |
| AI843915 | |
| D030041I09Rik | |
| naMN adenylyltransferase 1 | |
| nicotinate-nucleotide adenylyltransferase 1 | |
| KIAA0479 | |
| nicotinamide nucleotide adenylyltransferase 2 | |
| nicotinamide nucleotide adenylyltransferase II | |
| NMNAT2 | |
| OTTHUMP00000033548 | |
| pyridine nucleotide adenylyltransferase II | |
| nicotinamide mononucleotide adenylyltransferase 2 isoform I | |
| nicotinamide mononucleotide adenylyltransferase 2 isoform 2 | |
| OTTHUMP00000033549 | |
| D030041I09 | |
| nicotinamide mononucleotide adenylyltransferase II | |
| chromosome 1 open reading frame 15 | |
| MGC113818 | |
| MGC2756 | |
| nicotinamide mononucleotide adenylyltransferase 2 isoform 1 | |
| C330007D07 |
| Mouse chromosome position | 1 |
|---|
| OMIM ID | 608701 |
|---|
| Rat chromosome position | 13q21 |
|---|
| Hugo ID | 16789 |
|---|
| Human chromosome position | 1q25 |
|---|
| Swiss-Prot Accession | Q9BZQ4 |
|---|---|
| Q5HZI3 | |
| Q8BNJ3 | |
| Q0HA29 | |
| O75067 | |
| Q5T1Q3 | |
| Q8WU99 | |
| Q96QW1 |
| Unigene ID | Hs.497123 |
|---|---|
| Mm.40548 | |
| Rn.145458 |
| KEGG ID | hsa:23057 |
|---|---|
| mmu:226518 | |
| rno:289095 |
| Swiss-Prot ID | NMNA2_RAT |
|---|---|
| NMNA2_HUMAN | |
| NMNA2_MOUSE |
| EC Number | 2.7.7.18 |
|---|---|
| 2.7.7.1 |
| Ensembl ID | ENSG00000157064 |
|---|---|
| ENSP00000287713 | |
| ENST00000287713 | |
| ENSP00000294868 | |
| ENST00000294868 | |
| ENSMUSG00000042751 | |
| ENSMUSP00000041110 | |
| ENSMUST00000043313 | |
| ENSRNOG00000027697 | |
| ENSRNOP00000029020 | |
| ENSRNOT00000038183 |
| Homologene ID | 75037 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 2444155 |
|---|
| RGD ID | 1307331 |
|---|
| MedScan ID | 23057 |
|---|