| URN | urn:agi-llid:64802 |
|---|---|
| Total Entities | 0 |
| Connectivity | 142 |
| Name | Nmnat1 |
| Description | nicotinamide nucleotide adenylyltransferase 1 |
| Notes | This gene encodes an enzyme which catalyzes a key step in the biosynthesis of the coenzyme NAD. The encoded protein is one of several nicotinamide nucleotide adenylyltransferases. Studies in Drosophila and mammalian neurons have shown the encoded protein can confer protection to damaged neurons. This protection requires enzymatic activity which increases NAD levels and activates a nuclear deacetylase which is the protective molecule. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14 and 15. [provided by RefSeq, Dec 2011] |
| GO Molecular Function | nicotinamide-nucleotide adenylyltransferase activity |
|---|---|
| nicotinate-nucleotide adenylyltransferase activity | |
| ATP binding |
| GO Cellular Component | nucleoplasm |
|---|---|
| nucleus |
| GO Biological Process | small molecule metabolic process |
|---|---|
| NAD biosynthetic process | |
| vitamin metabolic process | |
| water-soluble vitamin metabolic process | |
| NAD metabolic process | |
| response to wounding |
| Pathway | nicotinamide adenine dinucleotide biosynthetic pathway |
|---|
| Group | NAD biosynthesis |
|---|---|
| small molecule metabolic process | |
| NAD biosynthetic process | |
| vitamin metabolic process | |
| water-soluble vitamin metabolic process | |
| NAD metabolic process | |
| response to wounding | |
| nicotinamide-nucleotide adenylyltransferase activity | |
| nicotinate-nucleotide adenylyltransferase activity | |
| ATP binding | |
| nucleoplasm | |
| nucleus |
| LocusLink ID | 64802 |
|---|---|
| 66454 | |
| 298653 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| GO ID | 0005524 |
|---|---|
| 0000309 | |
| 0004515 | |
| 0009435 | |
| 0019674 | |
| 0044281 | |
| 0006766 | |
| 0006767 | |
| 0005654 | |
| 0005634 | |
| 0009611 |
| Alias | LCA9 |
|---|---|
| NMNAT | |
| PNAT1 | |
| RP11-807G9.1 | |
| nicotinamide mononucleotide adenylyltransferase 1 | |
| NMN adenylyltransferase 1 | |
| NaMN adenylyltransferase 1 | |
| pyridine nucleotide adenylyltransferase 1 | |
| nicotinate-nucleotide adenylyltransferase 1 | |
| D4Cole1e | |
| 2610529L11Rik | |
| 5730441G13Rik | |
| RP23-173D8.7 | |
| NAD(+) diphosphorylase | |
| NAD(+) pyrophosphorylase | |
| deamido-NAD(+) diphosphorylase | |
| deamido-NAD(+) pyrophosphorylase | |
| nicotinamide mononucleotide adenylyl transferase | |
| nicotinamide/nicotinate mononucleotide adenylyltransferase 1 | |
| nicotinamide mononucleotide adenylyl transferase 1 | |
| nicotinate mononucleotide pyrophosphorylase | |
| NMNAT1 | |
| NMNAT I | |
| NMN adenylyltransferase; nicotinamide mononucleotide adenylyl transferase | |
| NMN adenylyltransferase, nicotinamide mononucleotide adenylyl transferase | |
| NMN adenylyltransferase | |
| nicotinate-nucleotide diphosphorylases | |
| OTTHUMP00000001731 | |
| nicotinate mononucleotide pyrophosphorylases | |
| OTTHUMP00000001732 | |
| OTTMUSP00000010940 | |
| OTTMUSP00000010941 | |
| nicotinamide/nicotinate mononucleotide adenylyltransferase I | |
| PNAT I | |
| nicotinate-nucleotide adenylyltransferase | |
| pyridine nucleotide adenylyltransferase I | |
| UFD2/D4COLE1E fusion protein | |
| RIKEN cDNA 5730441G13 gene | |
| 2610529L11 | |
| OTTMUSP00000038629 | |
| deamido-NAD pyrophosphorylase | |
| 4933408N02 | |
| 5730441G13 | |
| nicotinate-nucleotide diphosphorylase | |
| deamido-NAD diphosphorylase | |
| DNA segment, Chr 4, Michael Coleman 1, expressed | |
| likely ortholog of D4Cole1e, mutated in the slow Wallerian degeneration | |
| MGC156478 | |
| NAD diphosphorylase | |
| NAD pyrophosphorylase | |
| nicotinamide nucleotide adenylyltransferase 1 | |
| nicotinamide nucleotide adenylyltransferase | |
| NAD(+) pyrophosphorylases | |
| NAD pyrophosphorylases | |
| nicotinamide nucleotide adenylyltransferase I |
| Mouse chromosome position | 4 |
|---|
| OMIM ID | 608700 |
|---|---|
| 608553 |
| Rat chromosome position | 5q36 |
|---|
| Hugo ID | 17877 |
|---|
| Human chromosome position | 1p36.22 |
|---|
| Swiss-Prot Accession | Q9HAN9 |
|---|---|
| B1AN62 | |
| Q3V449 | |
| Q9EPA7 | |
| A0JPJ0 | |
| Q6B504 | |
| B1AN63 | |
| Q8TAE9 | |
| Q9H247 | |
| Q9H6B6 |
| Unigene ID | Hs.633762 |
|---|---|
| Mm.76062 | |
| Rn.147523 |
| KEGG ID | hsa:64802 |
|---|---|
| mmu:66454 | |
| rno:298653 |
| Swiss-Prot ID | NMNA1_MOUSE |
|---|---|
| NMNA1_HUMAN |
| EC Number | 2.7.7.18 |
|---|---|
| 2.7.7.1 |
| Ensembl ID | ENSG00000173614 |
|---|---|
| ENSP00000366410 | |
| ENST00000377205 | |
| ENSMUSG00000028992 | |
| ENSMUSP00000101318 | |
| ENSMUST00000105693 | |
| ENSRNOG00000015962 | |
| ENSRNOP00000041982 | |
| ENSRNOT00000048914 |
| Homologene ID | 39074 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1913704 |
|---|
| RGD ID | 1310996 |
|---|
| MedScan ID | 64802 |
|---|