| URN | urn:agi-llid:1371 |
|---|---|
| Connectivity | 16 |
| Name | Cpox |
| Description | coproporphyrinogen oxidase |
| Notes | Coproporphyrinogen oxidase (EC 1.3.3.3) is the sixth enzyme of the heme biosynthetic pathway. This soluble protein is localized in the intermembrane space of mitochondria and catalyzes the stepwise oxidative decarboxylation of the heme precursor coproporphyrinogen III to protoporphyrinogen IX via the tricarboxylic intermediate harderoporphyrinogen.[supplied by OMIM] |
| Pathway | New Pathway (1) |
|---|---|
| heme biosynthetic pathway |
| Ariadne Ontology | Tetrapyrroles biosynthesis |
|---|
| GO Molecular Function | protein self-association |
|---|---|
| identical protein binding | |
| oxidoreductase activity | |
| coproporphyrinogen oxidase activity |
| GO Cellular Component | mitochondrion |
|---|---|
| mitochondrial intermembrane space |
| GO Biological Process | porphyrin biosynthetic process |
|---|---|
| heme biosynthetic process | |
| oxidation reduction | |
| response to drug | |
| response to inorganic substance | |
| response to arsenic | |
| response to mercury ion |
| Group | Tetrapyrroles biosynthesis |
|---|---|
| mitochondrion | |
| mitochondrial intermembrane space | |
| protein self-association | |
| identical protein binding | |
| oxidoreductase activity | |
| coproporphyrinogen oxidase activity | |
| porphyrin biosynthetic process | |
| heme biosynthetic process | |
| oxidation reduction | |
| response to drug | |
| response to inorganic substance | |
| response to arsenic | |
| response to mercury ion |
| Hugo ID | 2321 |
|---|
| Human chromosome position | 3q12 |
|---|
| LocusLink ID | 1371 |
|---|---|
| 12892 | |
| 304024 |
| Alias | CPO |
|---|---|
| CPX | |
| HCP | |
| coproporphyrinogen oxidase | |
| coproporphyrinogen oxidase (coproporphyria, harderoporphyria) | |
| clone 560 | |
| Coproporphyrinogen III oxidase, mitochondrial precursor (Coproporphyrinogenase) (Coprogen oxidase) (COX) | |
| MGC124847 | |
| Coproporphyrinogenase | |
| CPOX | |
| Coproporphyrinogen III oxidase, mitochondrial precursor | |
| mitochondrial Coproporphyrinogen III oxidase precursor | |
| Coprogen oxidase | |
| Coproporphyrinogen III oxidase, mitochondrial precursor (Coproporphyrinogenase) (Coprogen oxidase) | |
| LOC131130 | |
| LOC151666 | |
| LOC201541 | |
| LOC224248 | |
| LOC436366 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 612732 |
|---|---|
| 121300 |
| Swiss-Prot Accession | A8K275 |
|---|---|
| P36551 | |
| P36552 | |
| Q3U029 | |
| Q3B7D0 |
| Unigene ID | Hs.476982 |
|---|---|
| Mm.291519 | |
| Rn.19581 |
| KEGG ID | hsa:1371 |
|---|---|
| mmu:12892 | |
| rno:304024 |
| EC Number | 1.3.3.3 |
|---|
| Swiss-Prot ID | HEM6_HUMAN |
|---|---|
| HEM6_MOUSE | |
| HEM6_RAT | |
| A8K275_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0004109 |
|---|---|
| 0016491 | |
| 0043621 | |
| 0006783 | |
| 0055114 | |
| 0046685 | |
| 0042493 | |
| 0046689 | |
| 0005758 | |
| 0005739 | |
| 0006779 | |
| 0042802 | |
| 0010035 |
| IPI ID | IPI00093057 |
|---|---|
| IPI00796846 | |
| IPI00793757 | |
| IPI00794067 | |
| IPI00400301 | |
| IPI00191745 |
| Homologene ID | 76 |
|---|
| MGI ID | 104841 |
|---|
| Rat chromosome position | 11q12 |
|---|
| RGD ID | 1311817 |
|---|