Protein Fech

URN	urn:agi-llid:2235
Total Entities	0
Connectivity	254
Name	Fech
Description	ferrochelatase (protoporphyria)
Notes	The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

GO Molecular Function	lyase activity
	ferrochelatase activity
	tetrapyrrole binding
	iron-responsive element binding
	heme binding
	metal ion binding
	iron ion binding
	ferrous iron binding
	iron-sulfur cluster binding
	2 iron, 2 sulfur cluster binding

GO Cellular Component	membrane
	mitochondrial inner membrane
	mitochondrial matrix
	mitochondrion

GO Biological Process	erythrocyte differentiation
	small molecule metabolic process
	heme biosynthetic process
	cholesterol metabolic process
	heme metabolic process
	regulation of eIF2 alpha phosphorylation by heme
	very-low-density lipoprotein particle assembly
	response to drug
	response to arsenic-containing substance
	response to ethanol
	cellular response to dexamethasone stimulus
	response to metal ion
	response to platinum ion
	response to lead ion
	response to methylmercury
	response to insecticide
	detection of UV
	response to light stimulus
	regulation of hemoglobin biosynthetic process
	generation of precursor metabolites and energy
	porphyrin-containing compound biosynthetic process
	porphyrin-containing compound metabolic process
	protoporphyrinogen IX metabolic process
	iron ion homeostasis

Pathway	heme biosynthetic pathway

Group	Tetrapyrroles biosynthesis
	erythrocyte differentiation
	small molecule metabolic process
	heme biosynthetic process
	cholesterol metabolic process
	heme metabolic process
	regulation of eIF2 alpha phosphorylation by heme
	very-low-density lipoprotein particle assembly
	response to drug
	response to arsenic-containing substance
	response to ethanol
	cellular response to dexamethasone stimulus
	response to metal ion
	response to platinum ion
	response to lead ion
	response to methylmercury
	response to insecticide
	detection of UV
	response to light stimulus
	regulation of hemoglobin biosynthetic process
	lyase activity
	ferrochelatase activity
	generation of precursor metabolites and energy
	porphyrin-containing compound biosynthetic process
	porphyrin-containing compound metabolic process
	protoporphyrinogen IX metabolic process
	iron ion homeostasis
	tetrapyrrole binding
	iron-responsive element binding
	heme binding
	metal ion binding
	iron ion binding
	ferrous iron binding
	iron-sulfur cluster binding
	2 iron, 2 sulfur cluster binding
	membrane
	mitochondrial inner membrane
	mitochondrial matrix
	mitochondrion

Cell Localization	Cytoplasm
	Mitochondrion inner membrane

Alias	EPP
	FCE
	ferrochelatase, mitochondrial
	heme synthase
	protoporphyria
	heme synthetase
	protoheme ferro-lyase
	Fcl
	fch
	AI894116
	iron chelatase
	iron chelatases
	heme synthetases
	heme synthases
	ferro-protoporphyrin chelatases
	ferrochelatase (protoporphyria)
	ferrochelatase
	FECH
	Protoheme ferro- lyase
	ferro-protoporphyrin chelatase

Mouse chromosome position	18 37.43 cM
	18 39.0 cM

OMIM ID	612386
	177000

Rat chromosome position	18q12.1

Hugo ID	3647

Human chromosome position	18q21.3

PIR ID	A36403

EC Number	4.99.1.1

Homologene ID	113

MGI ID	95513

RGD ID	1307556

MedScan ID	2235