| URN | urn:agi-llid:7389 |
|---|---|
| Total Entities | 0 |
| Connectivity | 106 |
| Name | Urod |
| Description | uroporphyrinogen decarboxylase |
| Notes | This gene encodes the fifth enzyme of the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria. [provided by RefSeq] |
| GO Molecular Function | lyase activity |
|---|---|
| carboxy-lyase activity | |
| uroporphyrinogen decarboxylase activity | |
| ferrous iron binding |
| GO Cellular Component | nucleolus |
|---|---|
| cytoplasm | |
| cytosol | |
| microtubule cytoskeleton | |
| nucleus |
| GO Biological Process | small molecule metabolic process |
|---|---|
| heme biosynthetic process | |
| protoporphyrinogen IX biosynthetic process | |
| uroporphyrinogen III metabolic process | |
| heme metabolic process | |
| liver development | |
| response to estradiol | |
| response to ethanol | |
| response to iron ion | |
| response to mercury ion | |
| cellular response to arsenic-containing substance | |
| response to methylmercury | |
| response to organic cyclic compound | |
| response to amine | |
| response to fungicide | |
| porphyrin-containing compound biosynthetic process | |
| porphyrin-containing compound metabolic process |
| Pathway | heme biosynthetic pathway |
|---|
| Group | Tetrapyrroles biosynthesis |
|---|---|
| small molecule metabolic process | |
| heme biosynthetic process | |
| protoporphyrinogen IX biosynthetic process | |
| uroporphyrinogen III metabolic process | |
| heme metabolic process | |
| liver development | |
| response to estradiol | |
| response to ethanol | |
| response to iron ion | |
| response to mercury ion | |
| cellular response to arsenic-containing substance | |
| response to methylmercury | |
| response to organic cyclic compound | |
| response to amine | |
| response to fungicide | |
| lyase activity | |
| carboxy-lyase activity | |
| uroporphyrinogen decarboxylase activity | |
| porphyrin-containing compound biosynthetic process | |
| porphyrin-containing compound metabolic process | |
| ferrous iron binding | |
| nucleolus | |
| cytoplasm | |
| cytosol | |
| microtubule cytoskeleton | |
| nucleus |
| LocusLink ID | 7389 |
|---|---|
| 22275 | |
| 29421 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0004853 |
|---|---|
| 0006783 | |
| 0006778 | |
| 0006782 | |
| 0044281 | |
| 0005737 | |
| 0005829 | |
| 0015630 | |
| 0005730 | |
| 0005634 | |
| 0016831 | |
| 0008198 | |
| 0016829 | |
| 0042168 | |
| 0006779 | |
| 0046502 | |
| 0071243 | |
| 0001889 | |
| 0014075 | |
| 0032355 | |
| 0045471 | |
| 0060992 | |
| 0010039 | |
| 0046689 | |
| 0051597 | |
| 0014070 |
| Alias | PCT |
|---|---|
| UPD | |
| RP11-69J16.2 | |
| uroporphyrinogen decarboxylase | |
| uroporphyrinogen III decarboxylase | |
| Uro-d | |
| AI323803 | |
| RP23-419D6.3 | |
| porphyrinogen carboxy-lyase | |
| porphyrinogen carboxylase | |
| porphyrinogen decarboxylases | |
| Uro-decarboxylase | |
| Uro-III decarboxylase | |
| Urod | |
| LOC362569 | |
| porphyrinogen decarboxylase | |
| fifth enzyme of the heme biosynthetic pathway | |
| OTTHUMP00000010502 | |
| OTTHUMP00000010503 | |
| OTTMUSP00000010340 | |
| porphyrinogen carboxy-lyases | |
| fifth enzyme of heme biosynthetic pathway |
| Mouse chromosome position | 4 53.41 cM |
|---|---|
| 4 50.6 cM |
| OMIM ID | 613521 |
|---|---|
| 176100 |
| Rat chromosome position | 5q36 |
|---|
| Hugo ID | 12591 |
|---|
| Human chromosome position | 1p34 |
|---|
| Swiss-Prot Accession | P06132 |
|---|---|
| P70697 | |
| B0BN55 | |
| P32362 | |
| Q91VW4 | |
| A8K762 | |
| Q16863 | |
| Q16883 | |
| Q53YB8 | |
| Q53ZP6 | |
| Q6IB28 | |
| Q9BUZ0 | |
| Q5T450 | |
| Q71UD4 | |
| Q71UD5 |
| PIR ID | T10088 |
|---|---|
| A24411 | |
| G02786 |
| Unigene ID | Hs.78601 |
|---|---|
| Mm.46484 | |
| Rn.4214 |
| KEGG ID | hsa:7389 |
|---|---|
| mmu:22275 | |
| rno:29421 |
| Swiss-Prot ID | DCUP_MOUSE |
|---|---|
| DCUP_HUMAN | |
| A8K762_HUMAN | |
| B0BN55_RAT |
| EC Number | 4.1.1.37 |
|---|
| Ensembl ID | ENSG00000126088 |
|---|---|
| ENSP00000246337 | |
| ENST00000246337 | |
| ENSMUSG00000028684 | |
| ENSMUSP00000030446 | |
| ENSMUST00000030446 | |
| ENSRNOG00000018211 | |
| ENSRNOP00000024719 | |
| ENSRNOT00000024719 |
| Homologene ID | 320 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 98916 |
|---|
| RGD ID | 3946 |
|---|
| MedScan ID | 7389 |
|---|
| IPI ID | IPI00301489 |
|---|---|
| IPI00514944 | |
| IPI00514662 | |
| IPI00111958 | |
| IPI00856192 | |
| IPI00886445 | |
| IPI00766976 |