| URN | urn:agi-llid:210 |
|---|---|
| Total Entities | 0 |
| Connectivity | 268 |
| Name | Alad |
| Description | aminolevulinate, delta-, dehydratase |
| Notes | The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. [provided by RefSeq] |
| GO Molecular Function | catalytic activity |
|---|---|
| lyase activity | |
| porphobilinogen synthase activity | |
| metal ion binding | |
| lead ion binding | |
| zinc ion binding |
| GO Cellular Component | cytosol |
|---|---|
| extracellular space |
| GO Biological Process | metabolic process |
|---|---|
| small molecule metabolic process | |
| heme biosynthetic process | |
| protoporphyrinogen IX biosynthetic process | |
| response to activity | |
| response to inorganic substance | |
| response to toxic substance | |
| response to drug | |
| response to organic substance | |
| response to nutrient | |
| response to arsenic-containing substance | |
| response to amino acid | |
| response to vitamin E | |
| response to fatty acid | |
| response to lipopolysaccharide | |
| response to ethanol | |
| response to selenium ion | |
| response to metal ion | |
| response to platinum ion | |
| response to lead ion | |
| response to iron ion | |
| response to cadmium ion | |
| response to cobalt ion | |
| response to mercury ion | |
| response to zinc ion | |
| response to aluminum ion | |
| cellular response to lead ion | |
| cellular response to interleukin-4 | |
| response to hormone | |
| response to methylmercury | |
| response to organic cyclic compound | |
| response to glucocorticoid | |
| response to vitamin B1 | |
| response to vitamin | |
| response to herbicide | |
| response to hypoxia | |
| response to oxidative stress | |
| response to nutrient levels | |
| response to ionizing radiation | |
| tetrapyrrole biosynthetic process | |
| porphyrin-containing compound biosynthetic process | |
| porphyrin-containing compound metabolic process | |
| protein homooligomerization |
| Pathway | heme biosynthetic pathway |
|---|
| Group | Tetrapyrroles biosynthesis |
|---|---|
| metabolic process | |
| small molecule metabolic process | |
| heme biosynthetic process | |
| protoporphyrinogen IX biosynthetic process | |
| response to activity | |
| response to inorganic substance | |
| response to toxic substance | |
| response to drug | |
| response to organic substance | |
| response to nutrient | |
| response to arsenic-containing substance | |
| response to amino acid | |
| response to vitamin E | |
| response to fatty acid | |
| response to lipopolysaccharide | |
| response to ethanol | |
| response to selenium ion | |
| response to metal ion | |
| response to platinum ion | |
| response to lead ion | |
| response to iron ion | |
| response to cadmium ion | |
| response to cobalt ion | |
| response to mercury ion | |
| response to zinc ion | |
| response to aluminum ion | |
| cellular response to lead ion | |
| cellular response to interleukin-4 | |
| response to hormone | |
| response to methylmercury | |
| response to organic cyclic compound | |
| response to glucocorticoid | |
| response to vitamin B1 | |
| response to vitamin | |
| response to herbicide | |
| response to hypoxia | |
| response to oxidative stress | |
| response to nutrient levels | |
| response to ionizing radiation | |
| catalytic activity | |
| lyase activity | |
| porphobilinogen synthase activity | |
| tetrapyrrole biosynthetic process | |
| porphyrin-containing compound biosynthetic process | |
| porphyrin-containing compound metabolic process | |
| protein homooligomerization | |
| metal ion binding | |
| lead ion binding | |
| zinc ion binding | |
| cytosol | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 210 |
|---|---|
| 17025 | |
| 25374 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0003824 |
|---|---|
| 0032791 | |
| 0004655 | |
| 0008270 | |
| 0071353 | |
| 0006783 | |
| 0006778 | |
| 0051260 | |
| 0006782 | |
| 0044281 | |
| 0005829 | |
| 0016829 | |
| 0046872 | |
| 0008152 | |
| 0006779 | |
| 0046685 | |
| 0046686 | |
| 0042493 | |
| 0045471 | |
| 0010038 | |
| 0007584 | |
| 0010033 | |
| 0010043 | |
| 0033014 | |
| 0005615 | |
| 0071284 | |
| 0014823 | |
| 0010044 | |
| 0043200 | |
| 0032025 | |
| 0070542 | |
| 0051384 | |
| 0009635 | |
| 0009725 | |
| 0001666 | |
| 0010035 | |
| 0010212 | |
| 0010039 | |
| 0010288 | |
| 0032496 | |
| 0046689 | |
| 0051597 | |
| 0031667 | |
| 0014070 | |
| 0006979 | |
| 0070541 | |
| 0010269 | |
| 0009636 | |
| 0033273 | |
| 0010266 | |
| 0033197 | |
| 0042802 | |
| 0003674 | |
| 0042221 |
| Alias | PBGS |
|---|---|
| ALADH | |
| RP11-10I9.1 | |
| delta-aminolevulinic acid dehydratase | |
| porphobilinogen synthase | |
| aminolevulinate, delta-, dehydratase | |
| Lv | |
| RP24-189G18.9 | |
| ALADR | |
| aminolevulinatedelta-dehydratase | |
| delta - aminolevulinic acid dehydratase | |
| d-aminolevulinic acid dehydratase | |
| delta-aminolevulinate dehydrase | |
| delta-ALAD | |
| d-aminolevulinic dehydratases | |
| d-aminolevulinic dehydratase | |
| d-aminolevulinic dehydrases | |
| delta-aminolevulinate dehydratase | |
| d-aminolevulinic acid dehydratases | |
| d-aminolevulinic acid dehydrases | |
| d-aminolevulinic dehydrase | |
| delta-aminolevulinic acid dehydrase | |
| OTTMUSP00000009376 | |
| OTTMUSP00000009377 | |
| porphobilinogen synthetase | |
| 5-levulinic acid dehydratases | |
| d-aminolevulinic acid dehydrase | |
| MGC5057 | |
| 5-levulinic acid dehydratase | |
| d-aminolevulinate dehydratases | |
| 5-levulinic acid dehydrases | |
| ALAD | |
| aminolevulinate dehydrase | |
| aminolevulinate dehydratase | |
| aminolevulinate, delta-, dehydrase | |
| d-aminolevulinate dehydrase | |
| 5-levulinic acid dehydrase | |
| aminolevulinic acid dehydrase | |
| d-aminolevulinate dehydratase | |
| d-aminolevulinate dehydrases | |
| aminolevulinic dehydratases | |
| aminolevulinic dehydratase | |
| aminolevulinic dehydrases | |
| aminolevulinic dehydrase | |
| aminolevulinic acid dehydratase | |
| delta aminolevulinate dehydratase |
| Mouse chromosome position | 4 33.17 cM |
|---|---|
| 4 30.6 cM |
| OMIM ID | 125270 |
|---|---|
| 612740 |
| Rat chromosome position | 5q32-q34 |
|---|
| Hugo ID | 395 |
|---|
| Human chromosome position | 9q33.1 |
|---|
| Swiss-Prot Accession | P13716 |
|---|---|
| Q6ZMU0 | |
| P10518 | |
| Q9DD05 | |
| P06214 | |
| A8K375 | |
| B2R6F2 | |
| Q16870 | |
| Q16871 | |
| Q9BVQ9 | |
| Q3THV6 | |
| O89061 | |
| Q8VCZ1 |
| PIR ID | A24724 |
|---|---|
| A26478 | |
| S03187 |
| Unigene ID | Hs.1227 |
|---|---|
| Mm.6988 | |
| Rn.3941 |
| KEGG ID | hsa:210 |
|---|---|
| mmu:17025 | |
| rno:25374 |
| Swiss-Prot ID | HEM2_RAT |
|---|---|
| HEM2_HUMAN | |
| HEM2_MOUSE | |
| A8K375_HUMAN |
| EC Number | 4.2.1.24 |
|---|
| Ensembl ID | ENSG00000148218 |
|---|---|
| ENSP00000386284 | |
| ENST00000409155 | |
| ENSMUSG00000028393 | |
| ENSMUSP00000030090 | |
| ENSMUST00000030090 | |
| ENSRNOG00000015206 | |
| ENSRNOP00000020625 | |
| ENSRNOT00000020625 |
| Homologene ID | 16 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 96853 |
|---|
| RGD ID | 2083 |
|---|
| MedScan ID | 210 |
|---|
| IPI ID | IPI00442121 |
|---|---|
| IPI00790373 | |
| IPI00112719 | |
| IPI00201399 |