| URN | urn:agi-llid:1371 |
|---|---|
| Total Entities | 0 |
| Connectivity | 68 |
| Name | Cpox |
| Description | coproporphyrinogen oxidase |
| Notes | Coproporphyrinogen oxidase (EC 1.3.3.3) is the sixth enzyme of the heme biosynthetic pathway. This soluble protein is localized in the intermembrane space of mitochondria and catalyzes the stepwise oxidative decarboxylation of the heme precursor coproporphyrinogen III to protoporphyrinogen IX via the tricarboxylic intermediate harderoporphyrinogen.[supplied by OMIM] |
| GO Molecular Function | sodium:potassium-exchanging ATPase activity |
|---|---|
| oxidoreductase activity | |
| coproporphyrinogen oxidase activity | |
| protein homodimerization activity | |
| structural constituent of eye lens |
| GO Cellular Component | mitochondrial inner membrane |
|---|---|
| mitochondrial intermembrane space | |
| cytoplasm | |
| mitochondrion |
| GO Biological Process | small molecule metabolic process |
|---|---|
| oxidation-reduction process | |
| heme biosynthetic process | |
| protoporphyrinogen IX biosynthetic process | |
| ATP catabolic process | |
| sodium ion transmembrane transport | |
| potassium ion transmembrane transport | |
| sodium ion transport | |
| potassium ion transport | |
| response to inorganic substance | |
| response to arsenic-containing substance | |
| response to lead ion | |
| response to iron ion | |
| response to methylmercury | |
| response to insecticide | |
| porphyrin-containing compound biosynthetic process | |
| porphyrin-containing compound metabolic process |
| Pathway | heme biosynthetic pathway |
|---|
| Group | Tetrapyrroles biosynthesis |
|---|---|
| small molecule metabolic process | |
| oxidation-reduction process | |
| heme biosynthetic process | |
| protoporphyrinogen IX biosynthetic process | |
| ATP catabolic process | |
| sodium:potassium-exchanging ATPase activity | |
| oxidoreductase activity | |
| coproporphyrinogen oxidase activity | |
| sodium ion transmembrane transport | |
| potassium ion transmembrane transport | |
| sodium ion transport | |
| potassium ion transport | |
| response to inorganic substance | |
| response to arsenic-containing substance | |
| response to lead ion | |
| response to iron ion | |
| response to methylmercury | |
| response to insecticide | |
| porphyrin-containing compound biosynthetic process | |
| porphyrin-containing compound metabolic process | |
| protein homodimerization activity | |
| structural constituent of eye lens | |
| mitochondrial inner membrane | |
| mitochondrial intermembrane space | |
| cytoplasm | |
| mitochondrion |
| LocusLink ID | 1371 |
|---|---|
| 12892 | |
| 304024 |
| Cell Localization | Cytoplasm |
|---|---|
| Mitochondrion intermembrane space |
| GO ID | 0004109 |
|---|---|
| 0042803 | |
| 0006783 | |
| 0006778 | |
| 0006782 | |
| 0046685 | |
| 0017085 | |
| 0010039 | |
| 0010288 | |
| 0051597 | |
| 0044281 | |
| 0005737 | |
| 0005743 | |
| 0005758 | |
| 0005739 | |
| 0016491 | |
| 0005391 | |
| 0005212 | |
| 0006200 | |
| 0055114 | |
| 0006779 | |
| 0071805 | |
| 0006813 | |
| 0035725 | |
| 0006814 | |
| 0010035 | |
| 0043621 | |
| 0042493 | |
| 0046689 | |
| 0042802 |
| Alias | CPO |
|---|---|
| CPX | |
| HCP | |
| coproporphyrinogen-III oxidase, mitochondrial | |
| COX | |
| coprogen oxidase | |
| coproporphyrinogenase | |
| cac | |
| nct | |
| clone 560 | |
| Coproporphyrinogen III oxidase, mitochondrial precursor (Coproporphyrinogenase) (Coprogen oxidase) (COX) | |
| LOC201541 | |
| Nakano cataract (nct) | |
| LOC224248 | |
| LOC436366 | |
| MGC124847 | |
| Nakano cataract gene | |
| CPOX | |
| mitochondrial Coproporphyrinogen III oxidase | |
| coproporphyrinogen oxidase (coproporphyria, harderoporphyria) | |
| Coproporphyrinogen oxidase | |
| Coproporphyrinogen III oxidase, mitochondrial precursor (Coproporphyrinogenase) (Coprogen oxidase) | |
| Coproporphyrinogen III oxidase, mitochondrial | |
| LOC151666 | |
| LOC131130 | |
| Coproporphyrinogen III oxidase, mitochondrial precursor | |
| mitochondrial Coproporphyrinogen III oxidase precursor |
| Mouse chromosome position | 16 |
|---|
| OMIM ID | 612732 |
|---|---|
| 121300 |
| Rat chromosome position | 11q12 |
|---|
| Hugo ID | 2321 |
|---|
| Human chromosome position | 3q12 |
|---|
| Swiss-Prot Accession | P36551 |
|---|---|
| P36552 | |
| Q3B7D0 | |
| A8K275 | |
| Q14060 | |
| Q53F08 | |
| Q8IZ45 | |
| Q96AF3 | |
| Q7TQ36 | |
| Q8VD08 | |
| Q3U029 |
| PIR ID | I52444 |
|---|---|
| A48049 |
| Unigene ID | Hs.476982 |
|---|---|
| Mm.291519 | |
| Rn.19581 |
| KEGG ID | hsa:1371 |
|---|---|
| mmu:12892 | |
| rno:304024 |
| Swiss-Prot ID | HEM6_HUMAN |
|---|---|
| HEM6_MOUSE | |
| HEM6_RAT | |
| A8K275_HUMAN |
| EC Number | 1.3.3.3 |
|---|
| Ensembl ID | ENSG00000080819 |
|---|---|
| ENSP00000264193 | |
| ENST00000264193 | |
| ENSMUSG00000022742 | |
| ENSMUSP00000055455 | |
| ENSMUST00000060077 | |
| ENSRNOG00000001654 | |
| ENSRNOP00000002257 | |
| ENSRNOT00000002257 |
| Homologene ID | 76 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 104841 |
|---|---|
| 97287 |
| RGD ID | 1311817 |
|---|
| MedScan ID | 1371 |
|---|
| IPI ID | IPI00093057 |
|---|---|
| IPI00796846 | |
| IPI00793757 | |
| IPI00794067 | |
| IPI00400301 | |
| IPI00191745 |