Protein Tspo

URN	urn:agi-llid:706
Total Entities	0
Connectivity	703
Name	Tspo
Description	translocator protein (18kDa)
Notes	Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]

GO Molecular Function	benzodiazepine receptor activity
	cholesterol binding
	androgen binding

GO Cellular Component	membrane
	integral component of membrane
	mitochondrial outer membrane
	mitochondrion

GO Biological Process	cell proliferation
	steroid biosynthetic process
	regulation of steroid biosynthetic process
	heme biosynthetic process
	steroid metabolic process
	negative regulation of tumor necrosis factor production
	adrenal gland development
	positive regulation of glial cell proliferation
	negative regulation of glial cell proliferation
	peripheral nervous system axon regeneration
	glial cell migration
	response to pain
	behavioral response to pain
	aging
	contact inhibition
	signal transduction
	synaptic transmission
	apoptotic process
	positive regulation of apoptotic process
	positive regulation of necrotic cell death
	ion transport
	protein targeting to mitochondrion
	regulation of cholesterol transport
	anion transport
	positive regulation of calcium ion transport
	chloride transport
	response to drug
	response to testosterone
	cellular response to lipopolysaccharide
	response to progesterone
	response to manganese ion
	cellular response to zinc ion
	response to vitamin B1
	response to axon injury
	cellular hypotonic response
	positive regulation of mitochondrial depolarization
	positive regulation of reactive oxygen species metabolic process
	negative regulation of nitric oxide biosynthetic process

Pathway	Overview of Mitochondrial Dysfunction in Alzheimer's Disease
	Multiple Functions of Estrogen in Mitochondria in Alzheimer's Disease
	Proteins Involved in Pathogenesis of Epilepsy
	Proteins Involved in Pathogenesis of Myocardial Ischemia
	heme biosynthetic pathway

Group	cell proliferation
	steroid biosynthetic process
	regulation of steroid biosynthetic process
	heme biosynthetic process
	steroid metabolic process
	negative regulation of tumor necrosis factor production
	adrenal gland development
	positive regulation of glial cell proliferation
	negative regulation of glial cell proliferation
	peripheral nervous system axon regeneration
	glial cell migration
	response to pain
	behavioral response to pain
	aging
	contact inhibition
	signal transduction
	benzodiazepine receptor activity
	synaptic transmission
	apoptotic process
	positive regulation of apoptotic process
	positive regulation of necrotic cell death
	ion transport
	protein targeting to mitochondrion
	regulation of cholesterol transport
	anion transport
	positive regulation of calcium ion transport
	chloride transport
	response to drug
	response to testosterone
	cellular response to lipopolysaccharide
	response to progesterone
	response to manganese ion
	cellular response to zinc ion
	response to vitamin B1
	response to axon injury
	cellular hypotonic response
	positive regulation of mitochondrial depolarization
	positive regulation of reactive oxygen species metabolic process
	negative regulation of nitric oxide biosynthetic process
	cholesterol binding
	androgen binding
	membrane
	integral component of membrane
	mitochondrial outer membrane
	mitochondrion
	Secreted proteins

Cell Localization	Mitochondrion membrane

Alias	DBI
	IBP
	MBR
	PBR
	PBS
	BPBS
	BZRP
	PKBS
	PTBR
	mDRC
	pk18
	RP3-526I14.4
	translocator protein
	mitochondrial benzodiazepine receptor
	benzodiazepine peripheral binding site
	peripheral-type benzodiazepine receptor
	Tspo1
	isoquinoline-binding protein
	benzodiazepine receptor, peripheral
	Ptbzr
	PTBZR02
	RATPTBZR02
	Benzodiazepin receptor (peripheral)
	peripheral benzodiazapine receptors
	peripheral benzodiazepine receptor
	peripheral benzodiazapine receptor short form
	translocator protein (18kda)
	peripheral benzodiazapine receptor
	Tspo
	Peripheral-type benzodiazepine receptors
	benzodiazapine receptors
	PBR-S
	benzodiazapine receptor (peripheral)
	benzodiazepin receptor
	benzodiazepin receptors
	benzodiazepine receptor (peripheral)
	Mitochondrial benzodiazepine receptors
	isoquinoline binding protein
	OTTHUMP00000198251
	OTTHUMP00000028891
	benzodiazapine receptor

Mouse chromosome position	15 39.4 cM

OMIM ID	109610

Rat chromosome position	7q34

Hugo ID	1158

Human chromosome position	22q13.31

Homologene ID	574

MGI ID	88222

RGD ID	2228

MedScan ID	706