| URN | urn:agi-llid:210 |
|---|---|
| Connectivity | 46 |
| Name | Alad |
| Description | aminolevulinate, delta-, dehydratase |
| Notes | The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. [provided by RefSeq] |
| Pathway | New Pathway (1) |
|---|---|
| heme biosynthetic pathway |
| Ariadne Ontology | Tetrapyrroles biosynthesis |
|---|
| GO Molecular Function | molecular_function |
|---|---|
| catalytic activity | |
| metal ion binding | |
| zinc ion binding | |
| identical protein binding | |
| lyase activity | |
| porphobilinogen synthase activity |
| GO Cellular Component | cytosol |
|---|---|
| extracellular space |
| GO Biological Process | metabolic process |
|---|---|
| porphyrin biosynthetic process | |
| heme biosynthetic process | |
| tetrapyrrole biosynthetic process | |
| response to chemical stimulus | |
| response to drug | |
| response to organic substance | |
| response to nutrient | |
| response to metal ion | |
| response to arsenic | |
| response to lead ion | |
| response to cadmium ion | |
| response to zinc ion | |
| response to ethanol |
| Group | Tetrapyrroles biosynthesis |
|---|---|
| cytosol | |
| extracellular space | |
| molecular_function | |
| catalytic activity | |
| metal ion binding | |
| zinc ion binding | |
| identical protein binding | |
| lyase activity | |
| porphobilinogen synthase activity | |
| metabolic process | |
| porphyrin biosynthetic process | |
| heme biosynthetic process | |
| tetrapyrrole biosynthetic process | |
| response to chemical stimulus | |
| response to drug | |
| response to organic substance | |
| response to nutrient | |
| response to metal ion | |
| response to arsenic | |
| response to lead ion | |
| response to cadmium ion | |
| response to zinc ion | |
| response to ethanol |
| Hugo ID | 395 |
|---|
| Human chromosome position | 9q33.1 |
|---|
| LocusLink ID | 210 |
|---|---|
| 17025 | |
| 25374 |
| Alias | PBGS |
|---|---|
| ALADH | |
| MGC5057 | |
| delta-aminolevulinic acid dehydratase | |
| porphobilinogen synthase | |
| aminolevulinate dehydratase | |
| Lv | |
| RP24-189G18.9 | |
| OTTMUSP00000009376 | |
| OTTMUSP00000009377 | |
| delta-aminolevulinate dehydratase | |
| ALADR | |
| aminolevulinatedelta-dehydratase | |
| delta - aminolevulinic acid dehydratase | |
| ALAD | |
| aminolevulinate, delta-, dehydratase | |
| aminolevulinic dehydratases | |
| aminolevulinic dehydratase | |
| d-aminolevulinate dehydratase | |
| d-aminolevulinic acid dehydrase | |
| d-aminolevulinic acid dehydratase | |
| d-aminolevulinic dehydratase | |
| 5-levulinic acid dehydratase | |
| delta aminolevulinate dehydratase | |
| 5-levulinic acid dehydratases | |
| d-aminolevulinate dehydratases | |
| d-aminolevulinic acid dehydrases | |
| d-aminolevulinic acid dehydratases | |
| d-aminolevulinic dehydratases |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 125270 |
|---|
| Swiss-Prot Accession | A8K375 |
|---|---|
| P13716 | |
| Q6ZMU0 | |
| P10518 | |
| O89061 | |
| Q8VCZ1 | |
| Q9DD05 | |
| P06214 |
| Unigene ID | Hs.1227 |
|---|---|
| Mm.6988 | |
| Rn.3941 |
| KEGG ID | hsa:210 |
|---|---|
| mmu:17025 | |
| rno:25374 |
| EC Number | 4.2.1.24 |
|---|
| Swiss-Prot ID | HEM2_HUMAN |
|---|---|
| HEM2_MOUSE | |
| HEM2_RAT | |
| A8K375_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0042802 |
|---|---|
| 0016829 | |
| 0046872 | |
| 0004655 | |
| 0008270 | |
| 0006783 | |
| 0008152 | |
| 0005829 | |
| 0003824 | |
| 0006779 | |
| 0033014 | |
| 0003674 | |
| 0046685 | |
| 0046686 | |
| 0042221 | |
| 0042493 | |
| 0045471 | |
| 0010288 | |
| 0010038 | |
| 0007584 | |
| 0010033 | |
| 0010043 | |
| 0005615 |
| IPI ID | IPI00442121 |
|---|---|
| IPI00790373 | |
| IPI00112719 | |
| IPI00201399 |
| Mouse chromosome position | 4 30.6 cM |
|---|
| Homologene ID | 16 |
|---|
| MGI ID | 96853 |
|---|
| RGD ID | 2083 |
|---|