| URN | urn:agi-llid:7389 |
|---|---|
| Connectivity | 22 |
| Name | Urod |
| Description | uroporphyrinogen decarboxylase |
| Notes | This gene encodes the fifth enzyme of the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria. [provided by RefSeq] |
| Pathway | New Pathway (1) |
|---|---|
| heme biosynthetic pathway |
| Ariadne Ontology | Tetrapyrroles biosynthesis |
|---|
| GO Molecular Function | lyase activity |
|---|---|
| carboxy-lyase activity | |
| uroporphyrinogen decarboxylase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol |
| GO Biological Process | porphyrin biosynthetic process |
|---|---|
| heme biosynthetic process | |
| uroporphyrinogen III metabolic process | |
| heme metabolic process |
| Group | Tetrapyrroles biosynthesis |
|---|---|
| cytoplasm | |
| cytosol | |
| lyase activity | |
| carboxy-lyase activity | |
| uroporphyrinogen decarboxylase activity | |
| porphyrin biosynthetic process | |
| heme biosynthetic process | |
| uroporphyrinogen III metabolic process | |
| heme metabolic process |
| Hugo ID | 12591 |
|---|
| Human chromosome position | 1p34 |
|---|
| LocusLink ID | 7389 |
|---|---|
| 22275 | |
| 29421 |
| Alias | PCT |
|---|---|
| RP11-69J16.2 | |
| uroporphyrinogen decarboxylase | |
| OTTHUMP00000010502 | |
| uroporphyrinogen III decarboxylase | |
| fifth enzyme of heme biosynthetic pathway | |
| fifth enzyme of the heme biosynthetic pathway | |
| Uro-d | |
| AI323803 | |
| RP23-419D6.3 | |
| OTTMUSP00000010340 | |
| porphyrinogen carboxy-lyase | |
| porphyrinogen decarboxylase | |
| Urod | |
| porphyrinogen carboxy-lyases | |
| porphyrinogen decarboxylases | |
| LOC362569 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 176100 |
|---|
| Swiss-Prot Accession | A8K762 |
|---|---|
| P06132 | |
| Q53YB8 | |
| Q53ZP6 | |
| Q5T450 | |
| Q71UD4 | |
| Q71UD5 | |
| P70697 | |
| B0BN55 | |
| P32362 |
| Unigene ID | Hs.78601 |
|---|---|
| Mm.46484 | |
| Rn.4214 |
| KEGG ID | hsa:7389 |
|---|---|
| mmu:22275 | |
| rno:29421 |
| EC Number | 4.1.1.37 |
|---|
| Swiss-Prot ID | DCUP_HUMAN |
|---|---|
| DCUP_MOUSE | |
| A8K762_HUMAN | |
| B0BN55_RAT |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0016829 |
|---|---|
| 0004853 | |
| 0006783 | |
| 0005737 | |
| 0016831 | |
| 0042168 | |
| 0006779 | |
| 0005829 | |
| 0046502 |
| IPI ID | IPI00301489 |
|---|---|
| IPI00514944 | |
| IPI00514662 | |
| IPI00111958 | |
| IPI00856192 | |
| IPI00886445 | |
| IPI00766976 |
| Mouse chromosome position | 4 50.6 cM |
|---|
| Homologene ID | 320 |
|---|
| MGI ID | 98916 |
|---|
| Rat chromosome position | 5q36 |
|---|
| RGD ID | 3946 |
|---|