| URN | urn:agi-llid:501454 |
|---|---|
| Connectivity | 3 |
| Name | Oaz2 |
| Description | ornithine decarboxylase antizyme 2 |
| Notes | Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase but does not accelerate its degradation. [provided by RefSeq] |
| Pathway | New Pathway (6) |
|---|---|
| polyamine metabolic pathway |
| GO Molecular Function | ornithine decarboxylase inhibitor activity |
|---|
| Group | ornithine decarboxylase inhibitor activity |
|---|
| MedScan ID | 501454 |
|---|
| LocusLink ID | 501454 |
|---|
| Alias | RGD1562933 |
|---|---|
| ornithine decarboxylase antizyme 2 |
| Organism | Rattus norvegicus |
|---|
| GenBank ID | NC_005107 |
|---|---|
| NM_001109899 | |
| NW_047799 | |
| NW_001084873 | |
| AC_000076 | |
| AA924239 | |
| BI290904 | |
| CB586487 | |
| CR754315 |
| GO ID | 0008073 |
|---|
| Rat chromosome position | 8q24 |
|---|
| Unigene ID | Rn.2946 |
|---|
| KEGG ID | rno:501454 |
|---|
| IPI ID | IPI00207412 |
|---|
| RGD ID | 1562933 |
|---|