| URN | urn:agi-llid:51582 |
|---|---|
| Connectivity | 18 |
| Name | Azin1 |
| Description | antizyme inhibitor 1 |
| Notes | Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq] |
| Pathway | New Pathway (6) |
|---|---|
| polyamine metabolic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| enzyme inhibitor activity | |
| ornithine decarboxylase inhibitor activity | |
| ornithine decarboxylase activator activity |
| GO Biological Process | polyamine biosynthetic process |
|---|---|
| polyamine metabolic process |
| Group | catalytic activity |
|---|---|
| polyamine biosynthetic process | |
| polyamine metabolic process | |
| enzyme inhibitor activity | |
| ornithine decarboxylase inhibitor activity | |
| ornithine decarboxylase activator activity |
| MedScan ID | 51582 |
|---|
| Hugo ID | 16432 |
|---|
| Human chromosome position | 8q22.3 |
|---|
| LocusLink ID | 51582 |
|---|---|
| 54375 | |
| 58961 |
| Alias | OAZI |
|---|---|
| OAZIN | |
| ODC1L | |
| MGC691 | |
| MGC3832 | |
| antizyme inhibitor 1 | |
| AZI | |
| ornithine decarboxylase 1-like | |
| ornithine decarboxylase antizyme inhibitor | |
| AI414949 | |
| 1700085L02Rik | |
| OTTMUSP00000029456 | |
| OTTMUSP00000029457 | |
| OTTMUSP00000029467 | |
| ODC antizyme inhibitor | |
| 1700085L02 | |
| antizyme inhibitor | |
| antizyme inhibitor I | |
| azin1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 607909 |
|---|
| Mouse chromosome position | 15 |
|---|
| GO ID | 0003824 |
|---|---|
| 0004857 | |
| 0042978 | |
| 0008073 | |
| 0006596 | |
| 0006595 |
| Rat chromosome position | 7q22 |
|---|
| Swiss-Prot Accession | O14977 |
|---|---|
| O35484 | |
| Q63764 | |
| Q6P7R3 | |
| Q542G5 | |
| Q8C2R8 | |
| Q8K1E5 | |
| A6NCD5 | |
| Q6IBQ7 | |
| Q96D20 |
| Unigene ID | Hs.459106 |
|---|---|
| Mm.250214 | |
| Rn.6290 |
| KEGG ID | hsa:51582 |
|---|---|
| mmu:54375 | |
| rno:58961 |
| Swiss-Prot ID | AZIN1_RAT |
|---|---|
| AZIN1_MOUSE | |
| AZIN1_HUMAN |
| IPI ID | IPI00211887 |
|---|---|
| IPI00857078 | |
| IPI00749254 | |
| IPI00857258 | |
| IPI00314954 | |
| IPI00857712 | |
| IPI00857338 |
| Homologene ID | 22933 |
|---|
| RGD ID | 61934 |
|---|
| MGI ID | 1859169 |
|---|