| URN | urn:agi-llid:6723 |
|---|---|
| Connectivity | 27 |
| Name | Srm |
| Description | spermidine synthase |
| Notes | The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq] |
| Pathway | methionine cycle/metabolic pathway |
|---|---|
| methionine cycle-metabolic pathway | |
| New Pathway (6) | |
| polyamine metabolic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| transferase activity | |
| spermidine synthase activity |
| GO Cellular Component | cytosol |
|---|
| GO Biological Process | spermidine biosynthetic process |
|---|
| Ariadne Ontology | Urea cycle |
|---|---|
| Asp-Lys-Thr-Met-Cys metabolsm |
| Group | Urea cycle |
|---|---|
| Asp-Lys-Thr-Met-Cys metabolsm | |
| catalytic activity | |
| spermidine biosynthetic process | |
| transferase activity | |
| spermidine synthase activity | |
| cytosol |
| MedScan ID | 6723 |
|---|
| Hugo ID | 11296 |
|---|
| Human chromosome position | 1p36-p22 |
|---|
| LocusLink ID | 6723 |
|---|---|
| 20810 | |
| 84596 |
| Alias | PAPT |
|---|---|
| SPS1 | |
| SPDSY | |
| SRML1 | |
| spermidine synthase | |
| spermidine synthase-1 | |
| putrescine aminopropyltransferase | |
| SpdST | |
| AA407669 | |
| RP23-331P21.3 | |
| OTTMUSP00000011743 | |
| aminopropyltransferase | |
| aminopropyltransferases | |
| OTTHUMP00000002170 | |
| Spermidine synthase I | |
| spermidine synthases | |
| spermidine synthetase | |
| Spermidine synthetase I | |
| Spermidine synthetase-1 | |
| spermidine synthetases | |
| SPS I | |
| Srm | |
| SRML I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 182891 |
|---|
| Mouse chromosome position | 4 |
|---|
| GO ID | 0004766 |
|---|---|
| 0016740 | |
| 0008295 | |
| 0005829 | |
| 0003824 |
| Rat chromosome position | 5q36 |
|---|
| Swiss-Prot Accession | P19623 |
|---|---|
| Q543H0 | |
| Q64674 | |
| Q3UJL7 | |
| Q8BSZ8 | |
| Q99MI5 | |
| B1AKP9 | |
| Q15511 |
| PIR ID | A32610 |
|---|
| Unigene ID | Hs.76244 |
|---|---|
| Mm.10 | |
| Rn.22258 |
| KEGG ID | hsa:6723 |
|---|---|
| mmu:20810 | |
| rno:84596 |
| EC Number | 2.5.1.16 |
|---|
| Swiss-Prot ID | SPEE_MOUSE |
|---|---|
| SPEE_HUMAN | |
| Q543H0_MOUSE | |
| Q99MI5_RAT | |
| B1AKP9_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00136912 |
|---|---|
| IPI00292020 | |
| IPI00197952 | |
| IPI00876231 |
| Homologene ID | 40514 |
|---|
| RGD ID | 620796 |
|---|
| MGI ID | 102690 |
|---|