| URN | urn:agi-llid:4946 |
|---|---|
| Connectivity | 66 |
| Name | Oaz1 |
| Description | ornithine decarboxylase antizyme 1 |
| Notes | Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and accelerates its degradation. [provided by RefSeq] |
| Pathway | New Pathway (6) |
|---|---|
| polyamine metabolic pathway |
| GO Molecular Function | enzyme inhibitor activity |
|---|---|
| ornithine decarboxylase inhibitor activity |
| GO Biological Process | polyamine biosynthetic process |
|---|---|
| polyamine metabolic process | |
| regulation of catalytic activity |
| Group | polyamine biosynthetic process |
|---|---|
| polyamine metabolic process | |
| regulation of catalytic activity | |
| enzyme inhibitor activity | |
| ornithine decarboxylase inhibitor activity |
| MedScan ID | 4946 |
|---|
| Hugo ID | 8095 |
|---|
| Human chromosome position | 19p13.3 |
|---|
| LocusLink ID | 4946 |
|---|---|
| 18245 | |
| 25502 |
| Alias | AZI |
|---|---|
| OAZ | |
| MGC138338 | |
| ornithine decarboxylase antizyme 1 | |
| ODC-Az | |
| antizyme 1 | |
| AZ1 | |
| AZ-1 | |
| Antizyme | |
| ODCAC | |
| antizyme I | |
| AZ I | |
| OAZ I | |
| OAZ1 | |
| Oaz1* | |
| Ornithine decarboxylase antizyme | |
| Ornithine decarboxylase antizyme (ODC-Az) | |
| ornithine decarboxylase antizyme I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601579 |
|---|
| Mouse chromosome position | 10 43.0 cM |
|---|
| GO ID | 0008073 |
|---|---|
| 0006596 | |
| 0004857 | |
| 0006595 | |
| 0050790 |
| Rat chromosome position | 7q11 |
|---|
| Swiss-Prot Accession | P54368 |
|---|---|
| Q2M222 | |
| P54369 | |
| Q52KL6 | |
| P54370 | |
| O43382 | |
| Q14989 | |
| Q92595 | |
| Q9UPL9 | |
| O08610 |
| PIR ID | I38591 |
|---|---|
| A55472 | |
| PC4378 |
| Unigene ID | Hs.446427 |
|---|---|
| Mm.398119 | |
| Rn.266 |
| KEGG ID | hsa:4946 |
|---|---|
| mmu:18245 | |
| rno:25502 |
| Swiss-Prot ID | OAZ1_HUMAN |
|---|---|
| OAZ1_RAT | |
| OAZ1_MOUSE |
| IPI ID | IPI00219773 |
|---|---|
| IPI00231409 | |
| IPI00229889 |
| Homologene ID | 7455 |
|---|
| RGD ID | 3219 |
|---|
| MGI ID | 109433 |
|---|