| URN | urn:agi-llid:4953 |
|---|---|
| Connectivity | 533 |
| Name | Odc1 |
| Description | ornithine decarboxylase 1 |
| Notes | This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq] |
| Pathway | New Pathway (6) |
|---|---|
| polyamine metabolic pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| lyase activity | |
| carboxy-lyase activity | |
| ornithine decarboxylase activity |
| GO Cellular Component | cytosol |
|---|
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| response to virus | |
| kidney development | |
| polyamine biosynthetic process | |
| putrescine biosynthetic process | |
| polyamine metabolic process |
| Ariadne Ontology | Urea cycle |
|---|
| Group | Urea cycle |
|---|---|
| catalytic activity | |
| positive regulation of cell proliferation | |
| response to virus | |
| kidney development | |
| polyamine biosynthetic process | |
| putrescine biosynthetic process | |
| polyamine metabolic process | |
| lyase activity | |
| carboxy-lyase activity | |
| ornithine decarboxylase activity | |
| cytosol |
| MedScan ID | 4953 |
|---|
| Hugo ID | 8109 |
|---|
| Human chromosome position | 2p25 |
|---|
| LocusLink ID | 4953 |
|---|---|
| 18263 | |
| 24609 |
| Alias | ODC |
|---|---|
| ornithine decarboxylase | |
| MGC103389 | |
| Ornitine decarboxylase | |
| ODC I | |
| ODC1 | |
| ornithine decarboxylase 1 | |
| ornithine decarboxylase I | |
| ornithine decarboxylase, structural | |
| ornithine decarboxylase, structural 1 | |
| RNODC |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 165640 |
|---|---|
| 114500 |
| Mouse chromosome position | 12 6.0 cM |
|---|
| GO ID | 0016829 |
|---|---|
| 0004586 | |
| 0001822 | |
| 0006596 | |
| 0008284 | |
| 0009615 | |
| 0005829 | |
| 0016831 | |
| 0003824 | |
| 0006595 | |
| 0009446 |
| Rat chromosome position | 6q16 |
|---|
| Swiss-Prot Accession | P11926 |
|---|---|
| Q53TU3 | |
| Q2F835 | |
| Q6PB87 | |
| P00860 | |
| Q3TM76 | |
| Q8CIC5 | |
| P09057 | |
| Q6LDS9 |
| PIR ID | A27361 |
|---|---|
| S06900 |
| Unigene ID | Hs.467701 |
|---|---|
| Mm.34102 | |
| Mm.472891 | |
| Rn.874 |
| KEGG ID | hsa:4953 |
|---|---|
| mmu:18263 | |
| rno:24609 |
| EC Number | 4.1.1.17 |
|---|
| Swiss-Prot ID | DCOR_RAT |
|---|---|
| DCOR_HUMAN | |
| Q53TU3_HUMAN | |
| Q6PB87_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00211162 |
|---|---|
| IPI00008497 | |
| IPI00844662 | |
| IPI00893027 | |
| IPI00893897 | |
| IPI00135743 |
| Homologene ID | 1906 |
|---|
| RGD ID | 3227 |
|---|
| MGI ID | 97402 |
|---|