| URN | urn:agi-llid:3794 |
|---|---|
| Connectivity | 144 |
| Name | Sat1 |
| Description | spermidine/spermine N1-acetyltransferase 1 |
| Notes | The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene. |
| Pathway | hypoxia inducible factor pathway |
|---|---|
| altered hypoxia inducible factor pathway | |
| polyamine metabolic pathway |
| GO Molecular Function | transferase activity |
|---|---|
| spermidine binding | |
| acyltransferase activity | |
| N-acetyltransferase activity | |
| diamine N-acetyltransferase activity |
| GO Cellular Component | intracellular |
|---|---|
| soluble fraction | |
| cytoplasm |
| GO Biological Process | metabolic process |
|---|---|
| regulation of cell proliferation | |
| polyamine metabolic process | |
| spermine catabolic process |
| Ariadne Ontology | Urea cycle |
|---|
| Group | Urea cycle |
|---|---|
| metabolic process | |
| regulation of cell proliferation | |
| polyamine metabolic process | |
| spermine catabolic process | |
| transferase activity | |
| spermidine binding | |
| acyltransferase activity | |
| N-acetyltransferase activity | |
| diamine N-acetyltransferase activity | |
| intracellular | |
| soluble fraction | |
| cytoplasm |
| MedScan ID | 3794 |
|---|
| Hugo ID | 10540 |
|---|
| Human chromosome position | Xp22.1 |
|---|
| LocusLink ID | 3794 |
|---|---|
| 6303 | |
| 20229 | |
| 302642 |
| Alias | SAT |
|---|---|
| DC21 | |
| KFSD | |
| SSAT | |
| KFSDX | |
| SSAT-1 | |
| diamine acetyltransferase 1 | |
| OTTHUMP00000023064 | |
| putrescine acetyltransferase | |
| diamine N-acetyltransferase 1 | |
| polyamine N-acetyltransferase 1 | |
| spermidine/spermine N(1)-acetyltransferase 1 | |
| spermidine/spermine N1-acetyltransferase alpha | |
| AA617398 | |
| RP23-440J5.9 | |
| OTTMUSP00000020874 | |
| Ab2-402 | |
| MGC72945 | |
| Spermidine / spermine N1-acyltransferase (diamine acetyltransferase) | |
| Sat_mapped | |
| DC 21 | |
| DC(21) | |
| DC-21 | |
| Diamine acetyltransferase | |
| keratosis follicularis spinulosa decalvans gene | |
| keratosis follicularis spinulosa decalvans protein | |
| OTTHUMP00000023061 | |
| spermidine transferase 1 | |
| spermidine/spermine N1-acetyl transferase | |
| spermidine/spermine N1-acetyl transferase 1 | |
| spermidine/spermine N1-acetyl transferase I | |
| spermidine/spermine N1-acetyltransferase | |
| spermidine/spermine N1-acetyltransferase 1 | |
| spermine n1-acyltransferase | |
| spermine n1-acyltransferase (diamine acetyltransferase) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 313020 |
|---|---|
| 308800 |
| Mouse chromosome position | X 65.2 cM |
|---|
| GO ID | 0008415 |
|---|---|
| 0004145 | |
| 0016740 | |
| 0008152 | |
| 0005737 | |
| 0005622 | |
| 0008080 | |
| 0019809 | |
| 0006595 | |
| 0042127 | |
| 0046208 | |
| 0005625 |
| Rat chromosome position | Xq22 |
|---|
| Swiss-Prot Accession | P21673 |
|---|---|
| Q6ICU9 | |
| Q2TM25 | |
| Q9H2N9 | |
| A2BES1 | |
| P48026 | |
| Q3V2Q2 | |
| Q6P9U6 | |
| Q7TP41 | |
| Q3U444 |
| PIR ID | S43429 |
|---|---|
| JH0783 |
| Unigene ID | Hs.28491 |
|---|---|
| Mm.2734 | |
| Mm.474481 | |
| Rn.107986 |
| KEGG ID | hsa:6303 |
|---|---|
| mmu:20229 | |
| rno:302642 |
| EC Number | 2.3.1.57 |
|---|
| Swiss-Prot ID | SAT1_MOUSE |
|---|---|
| SAT1_HUMAN | |
| Q6ICU9_HUMAN | |
| A2BES1_MOUSE | |
| Q6P9U6_RAT |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00137937 |
|---|---|
| IPI00009889 | |
| IPI00951830 | |
| IPI00872874 | |
| IPI00385876 | |
| IPI00644879 | |
| IPI00641408 | |
| IPI00830361 | |
| IPI00421622 |
| Homologene ID | 37716 |
|---|
| RGD ID | 1586174 |
|---|
| MGI ID | 98233 |
|---|