Ariadne Genomics Inc. S-adenosylmethionine methionine cycle/metabolic pathway S-adenosylmethioninamine putrescine ---> spermidine Srm spermidine ---> spermine spermine ---> spermidine Ornithine ---> putrescine Odc dimer urea cycle pathway Oaz1 ---| Odc dimer spermine ---> N-acetylspermine N-acetylspermine ---> spermidine Sms Azin1 ---| Oaz2 Azin1 ---| Oaz1 Oaz2 ---| Odc dimer Odc1 <--> Odc dimer Azin1 ---| Oaz3 Oaz3 ---| Odc dimer Oaz2 ---- Odc1 Oaz3 ---- Odc1 Oaz1 ---- Odc1 Ornithine putrescine spermidine spermine N-acetylspermidine N-acetylspermine Odc1 Oaz2 Oaz3 Oaz1 Azin1 S-adenosylmethionine ---> S-adenosylmethioninamine Amd1 Smox Sat1 Paox N-acetylspermidine ---> putrescine spermidine ---> N-acetylspermidine S-adenosylmethioninamine ---> spermidine S-adenosylmethioninamine ---> spermine