Ariadne Genomics Inc. phosphatases ---| Stat members phosphatases ---| Jak members Jak members --+> Stat members Jak members --+> leptin, cytokines, other receptors leptin, cytokines, other receptors --+> Jak members Pias members translocated Stat phosphatases Stat target genes Jak members Socs members Stat members leptin, cytokines, other receptors translocated Stat ---> Stat target genes Pias members ---| translocated Stat translocated Stat ---> Socs members Jak members ---- leptin, cytokines, other receptors leptin, cytokines, other receptors ---- Stat members Stat members ---> translocated Stat Socs members ---| leptin, cytokines, other receptors Socs members ---| Jak members PYs