Elsevier Inc. anti-diabetic drug pathway Abcc8 Kcnj11 type 2 diabetes mellitus diabetic complications other T2D candidate genes potential T2D miRNAs altered insulin secretion pathway Insr Akt2 altered insulin signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway altered insulin responsive facilitative sugar transporter mediated glucose transport pathway metformin drug pathway other T2D candidate genes ---> insulin gene expression potential T2D miRNAs ---> insulin secretion potential T2D miRNAs ---> insulin gene expression beta-cell function insulin gene expression insulin secretion other T2D candidate genes ---> insulin secretion Islet development potential T2D miRNAs ---> Islet development other T2D candidate genes ---> beta-cell function insulin action potential T2D miRNAs ---> insulin action anti-diabetic drug pathway ---| altered insulin secretion pathway high blood glucose potential T2D miRNAs ---> diabetic complications potential T2D miRNAs ---> type 2 diabetes mellitus metformin drug pathway ---| diabetic complications metformin drug pathway ---| type 2 diabetes mellitus metformin drug pathway ---| high blood glucose Ins