| URN | urn:agi-llid:23509 |
|---|---|
| Connectivity | 10 |
| Name | Pofut1 |
| Description | protein O-fucosyltransferase 1 |
| Notes | This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms. |
| Pathway | Notch signaling pathway |
|---|
| GO Molecular Function | transferase activity |
|---|---|
| manganese ion binding | |
| transferase activity, transferring glycosyl groups | |
| fucosyltransferase activity | |
| peptide-O-fucosyltransferase activity |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum |
| GO Biological Process | embryonic development |
|---|---|
| somitogenesis | |
| angiogenesis | |
| nervous system development | |
| heart development | |
| regulation of transcription | |
| protein amino acid O-linked glycosylation | |
| fucose metabolic process | |
| O-glycan processing | |
| carbohydrate metabolic process | |
| Notch signaling pathway |
| Group | embryonic development |
|---|---|
| somitogenesis | |
| angiogenesis | |
| nervous system development | |
| heart development | |
| regulation of transcription | |
| protein amino acid O-linked glycosylation | |
| fucose metabolic process | |
| O-glycan processing | |
| carbohydrate metabolic process | |
| Notch signaling pathway | |
| transferase activity | |
| manganese ion binding | |
| transferase activity, transferring glycosyl groups | |
| fucosyltransferase activity | |
| peptide-O-fucosyltransferase activity | |
| membrane | |
| endoplasmic reticulum |
| MedScan ID | 23509 |
|---|
| Hugo ID | 14988 |
|---|
| Human chromosome position | 20q11 |
|---|
| LocusLink ID | 23509 |
|---|---|
| 140484 | |
| 311551 |
| Alias | FUT12 |
|---|---|
| O-FUT | |
| MGC2482 | |
| O-Fuc-T | |
| KIAA0180 | |
| O-FucT-1 | |
| GDP-fucose protein O-fucosyltransferase 1 | |
| o-fucosyltransferase protein | |
| peptide-O-fucosyltransferase 1 | |
| mKIAA0180 | |
| RP23-192G18.5 | |
| OTTMUSP00000018129 | |
| OTTMUSP00000018163 | |
| GDP-fucose protein O-fucosyltransferase | |
| GDP-fucose protein O-fucosyltransferase I | |
| GDP-fucose protein O-fucosyltransferases | |
| GDP-fucose:polypeptide fucosyltransferase | |
| GDP-fucose:polypeptide fucosyltransferases | |
| GDP-L-fucose:polypeptide fucosyltransferase | |
| GDP-L-fucose:polypeptide fucosyltransferases | |
| O-FucT I | |
| O-Fuc-Ts | |
| OTTHUMP00000030583 | |
| OTTHUMP00000030584 | |
| peptide-O-fucosyltransferase | |
| peptide-O-fucosyltransferases | |
| POFUT I | |
| POFUT1 | |
| protein O-fucosyltransferase 1 | |
| protein O-fucosyltransferase I | |
| POFUT1s | |
| POFUT Is |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 607491 |
|---|
| Mouse chromosome position | 2 |
|---|---|
| 2 H2 |
| GO ID | 0008417 |
|---|---|
| 0046922 | |
| 0016757 | |
| 0007219 | |
| 0016266 | |
| 0001525 | |
| 0005975 | |
| 0009790 | |
| 0006004 | |
| 0007507 | |
| 0007399 | |
| 0006493 | |
| 0045449 | |
| 0001756 | |
| 0005783 | |
| 0016020 | |
| 0016740 | |
| 0030145 | |
| 0030173 | |
| 0003674 | |
| 0008150 | |
| 0005615 |
| Rat chromosome position | 3q41 |
|---|
| Swiss-Prot Accession | Q9H488 |
|---|---|
| Q91ZW2 | |
| A2AMC4 | |
| Q3UXG7 | |
| Q5DU44 | |
| Q6EV70 | |
| A8K4R8 | |
| Q14685 | |
| Q5W185 | |
| Q9BW76 | |
| Q3V1R0 | |
| Q8C8R4 |
| Unigene ID | Hs.472409 |
|---|---|
| Mm.293761 | |
| Rn.214685 |
| KEGG ID | hsa:23509 |
|---|---|
| mmu:140484 | |
| rno:311551 |
| EC Number | 2.4.1.221 |
|---|
| Swiss-Prot ID | OFUT1_HUMAN |
|---|---|
| OFUT1_MOUSE | |
| OFUT1_RAT | |
| A2AMC4_MOUSE | |
| A8K4R8_HUMAN | |
| Q5W185_HUMAN |
| Cell Localization | Endoplasmic reticulum |
|---|
| IPI ID | IPI00058192 |
|---|---|
| IPI00218176 | |
| IPI00131488 | |
| IPI00454554 | |
| IPI00554907 | |
| IPI00652221 | |
| IPI00753748 |
| Homologene ID | 9104 |
|---|
| RGD ID | 1303001 |
|---|
| MGI ID | 2153207 |
|---|