Ariadne Genomics Inc. Jag_ligands ---- Notch_receptors Jag_ligands Hey ---> regulation of transcription Maml Fng Rbpj ---> Hey Rbpj ---> Hes Hey Hes Rbpj gamma-convertase Notch_receptors Dll_ligands NICD gamma-convertase --+> Notch_receptors Notch_receptors ---> NICD Dll_ligands ---- Notch_receptors Adam10 --+> Notch_receptors Adam17 --+> Notch_receptors Fng --+> Notch_receptors Pofut1 --+> Notch_receptors Hes ---> regulation of transcription regulation of transcription Adam10 Adam17 Pofut1