Protein Prkdc

URN	urn:agi-llid:5591
Total Entities	0
Connectivity	405
Name	Prkdc
Description	protein kinase, DNA-activated, catalytic polypeptide
Notes	This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]

Ariadne Ontology	DNA repair
	Protein kinases
	Biofluids assayable substances

GO Molecular Function	transcription factor binding
	enzyme binding
	nucleotide binding
	ATP binding
	DNA binding
	transferase activity
	transferase activity, transferring phosphorus-containing groups
	phosphotransferase activity, alcohol group as acceptor
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	DNA-dependent protein kinase activity

GO Cellular Component	DNA-dependent protein kinase-DNA ligase 4 complex
	nucleoplasm
	nucleolus
	transcription factor complex
	nonhomologous end joining complex
	nucleus

GO Biological Process	germ cell programmed cell death
	positive regulation of transcription from RNA polymerase II promoter
	positive regulation of apoptotic process
	pro-B cell differentiation
	lymphocyte differentiation
	T cell differentiation in thymus
	B cell lineage commitment
	T cell lineage commitment
	DNA repair
	telomere maintenance
	double-strand break repair
	double-strand break repair via nonhomologous end joining
	immunoglobulin V(D)J recombination
	T cell receptor V(D)J recombination
	cellular protein modification process
	peptidyl-serine phosphorylation
	phosphorylation
	cellular response to insulin stimulus
	response to DNA damage stimulus
	apoptotic process
	response to gamma radiation
	protein destabilization
	somitogenesis
	brain development
	heart development

Pathway	Cell Cycle
	Double Strand DNA Non-Homologous Repair
	non-homologous end joining pathway of double-strand break repair

Group	DNA repair
	Protein kinases
	germ cell programmed cell death
	positive regulation of transcription from RNA polymerase II promoter
	positive regulation of apoptotic process
	pro-B cell differentiation
	lymphocyte differentiation
	T cell differentiation in thymus
	B cell lineage commitment
	T cell lineage commitment
	DNA repair
	telomere maintenance
	double-strand break repair
	double-strand break repair via nonhomologous end joining
	immunoglobulin V(D)J recombination
	T cell receptor V(D)J recombination
	cellular protein modification process
	peptidyl-serine phosphorylation
	phosphorylation
	cellular response to insulin stimulus
	response to DNA damage stimulus
	apoptotic process
	response to gamma radiation
	protein destabilization
	somitogenesis
	brain development
	heart development
	transcription factor binding
	enzyme binding
	nucleotide binding
	ATP binding
	DNA binding
	transferase activity
	transferase activity, transferring phosphorus-containing groups
	phosphotransferase activity, alcohol group as acceptor
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	DNA-dependent protein kinase activity
	DNA-dependent protein kinase-DNA ligase 4 complex
	nucleoplasm
	nucleolus
	transcription factor complex
	nonhomologous end joining complex
	nucleus
	Biofluids assayable substances

MedScan ID	5591

Hugo ID	9413

Human chromosome position	8q11

Alias	HYRC
	p350
	DNAPK
	DNPK1
	HYRC1
	XRCC7
	DNA-PKcs
	DNA-dependent protein kinase catalytic subunit
	p460
	DNA-PK catalytic subunit
	hyper-radiosensitivity of murine scid mutation, complementing 1
	scid
	slip
	dxnph
	DOXNPH
	DNAPDcs
	AI326420
	AU019811
	doxorubicin nephropathy
	severe combined immunodeficiency
	doxorubicin nephropathy gene
	hyper-radiosensitivity of murine scid mutation, complementing I
	HYRC I
	MGC189093
	PRKDC
	protein kinase, DNA activated, catalytic polypeptide
	DNA- PKcs
	complementing hyper-radiosensitivity of murine scid mutation
	DNAPDcss
	DNPK I

OMIM ID	600899

Unigene ID	Hs.491682
	Mm.71

KEGG ID	hsa:5591
	mmu:19090

EC Number	2.7.11.1

Swiss-Prot ID	PRKDC_MOUSE
	PRKDC_HUMAN

Mouse chromosome position	16 10.09 cM

Rat chromosome position	11q23

Homologene ID	5037

MGI ID	104779

RGD ID	1308982

Primary Cell Localization	Nucleus
	Cytoplasm