| URN | urn:agi-llid:79840 |
|---|---|
| Total Entities | 0 |
| Connectivity | 34 |
| Name | Nhej1 |
| Description | nonhomologous end-joining factor 1 |
| Notes | Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | DNA binding |
|---|
| GO Cellular Component | nonhomologous end joining complex |
|---|---|
| nucleus |
| GO Biological Process | T cell differentiation |
|---|---|
| B cell differentiation | |
| DNA repair | |
| DNA recombination | |
| double-strand break repair | |
| double-strand break repair via nonhomologous end joining | |
| response to DNA damage stimulus | |
| response to ionizing radiation | |
| positive regulation of ligase activity | |
| central nervous system development |
| Pathway | Double Strand DNA Non-Homologous Repair |
|---|---|
| non-homologous end joining pathway of double-strand break repair |
| Group | T cell differentiation |
|---|---|
| B cell differentiation | |
| DNA repair | |
| DNA recombination | |
| double-strand break repair | |
| double-strand break repair via nonhomologous end joining | |
| response to DNA damage stimulus | |
| response to ionizing radiation | |
| positive regulation of ligase activity | |
| central nervous system development | |
| DNA binding | |
| nonhomologous end joining complex | |
| nucleus |
| MedScan ID | 79840 |
|---|
| Hugo ID | 25737 |
|---|
| Human chromosome position | 2q35 |
|---|
| LocusLink ID | 79840 |
|---|---|
| 75570 | |
| 363251 |
| Alias | XLF |
|---|---|
| non-homologous end-joining factor 1 | |
| XRCC4-like factor | |
| protein cernunnos | |
| cernunnos | |
| 1700029B21Rik | |
| OTTMUSP00000024345 | |
| OTTHUMP00000206279 | |
| OTTHUMP00000206278 | |
| OTTHUMP00000206275 | |
| nonhomologous end-joining factor 1 | |
| mouse 1700029B21Rik protein | |
| MGC130192 | |
| MGC130191 | |
| FLJ12610 | |
| 1700029B21 | |
| Nhej1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 611290 |
|---|---|
| 611291 |
| Unigene ID | Hs.225988 |
|---|---|
| Mm.442409 | |
| Rn.35483 |
| KEGG ID | hsa:79840 |
|---|---|
| mmu:75570 | |
| rno:363251 |
| Swiss-Prot Accession | Q9H9Q4 |
|---|---|
| Q3KNJ2 | |
| Q6AYI4 | |
| B8ZZA4 | |
| Q4ZFW7 | |
| Q6IA64 | |
| Q96JS9 | |
| A2RT39 | |
| Q99JK0 | |
| Q9D9U0 |
| GO ID | 0003677 |
|---|---|
| 0030183 | |
| 0006310 | |
| 0030217 | |
| 0007417 | |
| 0006303 | |
| 0051351 | |
| 0010212 | |
| 0070419 | |
| 0005634 | |
| 0006281 | |
| 0006302 | |
| 0006974 |
| Swiss-Prot ID | NHEJ1_RAT |
|---|---|
| NHEJ1_HUMAN | |
| NHEJ1_MOUSE |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00464720 |
|---|---|
| IPI00549762 | |
| IPI00735288 | |
| IPI00115363 | |
| IPI00742397 |
| Mouse chromosome position | 1 |
|---|
| Rat chromosome position | 9q33 |
|---|
| Homologene ID | 11714 |
|---|
| MGI ID | 1922820 |
|---|
| RGD ID | 1359338 |
|---|