| URN | urn:agi-llid:200558 |
|---|---|
| Total Entities | 0 |
| Connectivity | 23 |
| Name | Aplf |
| Description | aprataxin and PNKP like factor |
| Notes | C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007 [PubMed 17353262]).[supplied by OMIM, Mar 2008] |
| GO Molecular Function | nucleotide binding |
|---|---|
| metal ion binding | |
| lyase activity | |
| endodeoxyribonuclease activity | |
| 3'-5' exonuclease activity | |
| DNA-(apurinic or apyrimidinic site) lyase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| nucleus |
| GO Biological Process | DNA repair |
|---|---|
| single strand break repair | |
| double-strand break repair | |
| response to DNA damage stimulus |
| Pathway | non-homologous end joining pathway of double-strand break repair |
|---|
| Group | DNA repair |
|---|---|
| single strand break repair | |
| double-strand break repair | |
| response to DNA damage stimulus | |
| nucleotide binding | |
| metal ion binding | |
| lyase activity | |
| endodeoxyribonuclease activity | |
| 3'-5' exonuclease activity | |
| DNA-(apurinic or apyrimidinic site) lyase activity | |
| cytoplasm | |
| cytosol | |
| nucleus |
| MedScan ID | 200558 |
|---|
| Hugo ID | 28724 |
|---|
| Human chromosome position | 2p13.3 |
|---|
| LocusLink ID | 200558 |
|---|---|
| 72103 | |
| 500247 |
| Alias | APFL |
|---|---|
| PALF | |
| Xip1 | |
| C2orf13 | |
| aprataxin and PNK-like factor | |
| XRCC1-interacting protein 1 | |
| PNK and APTX-like FHA protein | |
| aprataxin- and PNK-like factor | |
| apurinic-apyrimidinic endonuclease APLF | |
| PNK and APTX-like FHA domain-containing protein | |
| AI452191 | |
| 2010301N04Rik | |
| RGD1565557 | |
| FLJ16593 | |
| CG6171-PA | |
| aprataxin and PNKP like factor | |
| APLF | |
| 2010301N04 | |
| MGC47799 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 611035 |
|---|
| Unigene ID | Hs.720369 |
|---|---|
| Mm.31770 | |
| Rn.203883 |
| KEGG ID | hsa:200558 |
|---|---|
| mmu:72103 | |
| rno:500247 |
| Swiss-Prot Accession | Q8IW19 |
|---|---|
| Q9D842 | |
| A8K476 | |
| Q53P47 | |
| Q53PB9 | |
| Q53QU0 | |
| Q8BZL5 | |
| Q99LX6 |
| EC Number | 4.2.99.18 |
|---|
| GO ID | 0008408 |
|---|---|
| 0003906 | |
| 0004520 | |
| 0046872 | |
| 0000166 | |
| 0006302 | |
| 0006974 | |
| 0000012 | |
| 0005829 | |
| 0005634 | |
| 0016829 | |
| 0006281 | |
| 0005737 |
| Swiss-Prot ID | APLF_HUMAN |
|---|---|
| APLF_MOUSE |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm | |
| cytosol |
| IPI ID | IPI00217108 |
|---|---|
| IPI00110815 | |
| IPI00406210 | |
| IPI00649943 |
| Mouse chromosome position | 6 |
|---|
| Rat chromosome position | 4q34 |
|---|
| Homologene ID | 49753 |
|---|
| MGI ID | 1919353 |
|---|
| RGD ID | 1565557 |
|---|