Protein Xrcc5

URN	urn:agi-llid:7520
Total Entities	0
Connectivity	324
Name	Xrcc5
Description	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Notes	The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

Ariadne Ontology	DNA recombination
	DNA repair

GO Molecular Function	protein C-terminus binding
	ubiquitin protein ligase binding
	nucleotide binding
	ATP binding
	DNA binding
	telomeric DNA binding
	double-stranded telomeric DNA binding
	double-stranded DNA binding
	transcription regulatory region DNA binding
	hydrolase activity
	hydrolase activity, acting on acid anhydrides
	helicase activity
	ATP-dependent DNA helicase activity
	5'-deoxyribose-5-phosphate lyase activity

GO Cellular Component	Ku70:Ku80 complex
	DNA-dependent protein kinase-DNA ligase 4 complex
	nucleoplasm
	nucleolus
	nuclear telomere cap complex
	nuclear chromosome, telomeric region
	protein complex
	nonhomologous end joining complex
	cytoplasm
	chromosome
	nucleus

GO Biological Process	cell proliferation
	viral reproduction
	negative regulation of transcription, DNA-dependent
	regulation of transcription, DNA-dependent
	negative regulation of apoptotic process
	positive regulation of neurogenesis
	hematopoietic stem cell differentiation
	transcription, DNA-dependent
	DNA repair
	DNA recombination
	telomere maintenance
	double-strand break repair
	double-strand break repair via nonhomologous end joining
	cellular response to fatty acid
	response to DNA damage stimulus
	cellular hyperosmotic salinity response
	cellular response to X-ray
	response to drug
	brain development

Pathway	Telomere Maintenance
	Double Strand DNA Non-Homologous Repair
	non-homologous end joining pathway of double-strand break repair

Group	DNA recombination
	DNA repair
	cell proliferation
	viral reproduction
	negative regulation of transcription, DNA-dependent
	regulation of transcription, DNA-dependent
	negative regulation of apoptotic process
	positive regulation of neurogenesis
	hematopoietic stem cell differentiation
	transcription, DNA-dependent
	DNA repair
	DNA recombination
	telomere maintenance
	double-strand break repair
	double-strand break repair via nonhomologous end joining
	cellular response to fatty acid
	response to DNA damage stimulus
	cellular hyperosmotic salinity response
	cellular response to X-ray
	response to drug
	brain development
	protein C-terminus binding
	ubiquitin protein ligase binding
	nucleotide binding
	ATP binding
	DNA binding
	telomeric DNA binding
	double-stranded telomeric DNA binding
	double-stranded DNA binding
	transcription regulatory region DNA binding
	hydrolase activity
	hydrolase activity, acting on acid anhydrides
	helicase activity
	ATP-dependent DNA helicase activity
	5'-deoxyribose-5-phosphate lyase activity
	Ku70:Ku80 complex
	DNA-dependent protein kinase-DNA ligase 4 complex
	nucleoplasm
	nucleolus
	nuclear telomere cap complex
	nuclear chromosome, telomeric region
	protein complex
	nonhomologous end joining complex
	cytoplasm
	chromosome
	nucleus

MedScan ID	7520

Hugo ID	12833

Human chromosome position	2q35

Alias	KU80
	KUB2
	Ku86
	NFIV
	KARP1
	KARP-1
	X-ray repair cross-complementing protein 5
	TLAA
	CTC85
	CTCBF
	nuclear factor IV
	Ku autoantigen, 80kDa
	DNA repair protein XRCC5
	thyroid-lupus autoantigen
	86 kDa subunit of Ku antigen
	lupus Ku autoantigen protein p86
	Ku86 autoantigen related protein 1
	CTC box-binding factor 85 kDa subunit
	ATP-dependent DNA helicase 2 subunit 2
	ATP-dependent DNA helicase II 80 kDa subunit
	AI314015
	Ku p80
	ku autoantigen protein p86 homolog
	Kup80
	Ku autoantigen, 80kD)
	X-ray repair cross complementation (double-strand-break rejoining
	X-ray repair cross complementation (double-strand-break rejoining; Ku autoantigen, 80kD)
	G22P2
	Xrcc5
	LOC227269
	Ku86 autoantigen related protein I
	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
	OTTHUMP00000164061
	OTTHUMP00000206791
	X-ray repair complementing defective repair in Chinese hamster cells 5
	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kD)
	X-ray repair complementing defective repair in Chinese hamster cells V
	ATP-dependent DNA helicase II, 80 kDa subunit
	FLJ39089
	80 kDa Ku autoantigen
	ATP-dependant DNA helicase II
	ATP-dependent DNA helicase II
	CTC box binding factor 85 kDa subunit
	ku autoantigen
	KARP I
	double-strand-break rejoining protein

OMIM ID	194364

EC Number	3.6.4.-

Swiss-Prot ID	XRCC5_HUMAN
	XRCC5_MOUSE

IPI ID	IPI00220834
	IPI00321154

Mouse chromosome position	1 42.0 cM

Rat chromosome position	9q34

Homologene ID	40681

MGI ID	104517

RGD ID	3976

Primary Cell Localization	Nucleus