| URN | urn:agi-llid:7518 |
|---|---|
| Total Entities | 0 |
| Connectivity | 129 |
| Name | Xrcc4 |
| Description | X-ray repair complementing defective repair in Chinese hamster cells 4 |
| Notes | The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq, Sep 2008] |
| Ariadne Ontology | DNA repair |
|---|
| GO Molecular Function | protein C-terminus binding |
|---|---|
| DNA binding | |
| ligase activity |
| GO Cellular Component | DNA ligase IV complex |
|---|---|
| DNA-dependent protein kinase-DNA ligase 4 complex | |
| nucleoplasm | |
| nonhomologous end joining complex | |
| cytosol | |
| condensed chromosome | |
| nucleus |
| GO Biological Process | viral reproduction |
|---|---|
| negative regulation of neuron apoptotic process | |
| positive regulation of fibroblast proliferation | |
| positive regulation of neurogenesis | |
| pro-B cell differentiation | |
| T cell differentiation in thymus | |
| isotype switching | |
| DNA repair | |
| DNA ligation | |
| DNA recombination | |
| double-strand break repair | |
| double-strand break repair via nonhomologous end joining | |
| V(D)J recombination | |
| immunoglobulin V(D)J recombination | |
| DNA ligation involved in DNA repair | |
| cellular response to lithium ion | |
| response to DNA damage stimulus | |
| response to ionizing radiation | |
| response to X-ray | |
| response to gamma radiation | |
| positive regulation of ligase activity | |
| central nervous system development | |
| in utero embryonic development |
| Pathway | Double Strand DNA Non-Homologous Repair |
|---|---|
| non-homologous end joining pathway of double-strand break repair |
| Group | DNA repair |
|---|---|
| viral reproduction | |
| negative regulation of neuron apoptotic process | |
| positive regulation of fibroblast proliferation | |
| positive regulation of neurogenesis | |
| pro-B cell differentiation | |
| T cell differentiation in thymus | |
| isotype switching | |
| DNA repair | |
| DNA ligation | |
| DNA recombination | |
| double-strand break repair | |
| double-strand break repair via nonhomologous end joining | |
| V(D)J recombination | |
| immunoglobulin V(D)J recombination | |
| DNA ligation involved in DNA repair | |
| cellular response to lithium ion | |
| response to DNA damage stimulus | |
| response to ionizing radiation | |
| response to X-ray | |
| response to gamma radiation | |
| positive regulation of ligase activity | |
| central nervous system development | |
| in utero embryonic development | |
| protein C-terminus binding | |
| DNA binding | |
| ligase activity | |
| DNA ligase IV complex | |
| DNA-dependent protein kinase-DNA ligase 4 complex | |
| nucleoplasm | |
| nonhomologous end joining complex | |
| cytosol | |
| condensed chromosome | |
| nucleus |
| MedScan ID | 7518 |
|---|---|
| 626368 |
| Hugo ID | 12831 |
|---|
| Human chromosome position | 5q14.2 |
|---|
| LocusLink ID | 7518 |
|---|---|
| 108138 | |
| 309995 | |
| 100044170 |
| Alias | DNA repair protein XRCC4 |
|---|---|
| X-ray repair cross-complementing protein 4 | |
| X-ray repair, complementing defective, repair in Chinese hamster | |
| AW413319 | |
| AW545101 | |
| 2310057B22Rik | |
| X-ray repair cross complementing protein 4 | |
| X-ray repair cross complementing 4 | |
| X-ray repair complementing defective repair in Chinese hamster cells IV | |
| Xrcc4 | |
| X-ray repair cross complementing protein 4 isoform II | |
| X-ray repair cross complementing protein 4 isoform I | |
| X-ray repair cross complementing protein 4 isoform 2 | |
| X-ray repair cross complementing protein 4 isoform 1 | |
| 2310057B22 | |
| MGC95022 | |
| DNA double-strand break repair and V( D) J recombination protein XRCC4 | |
| X-ray repair cross complementing IV | |
| X-ray repair complementing defective repair in Chinese hamster cells 4 | |
| LOC100044170 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 194363 |
|---|
| Unigene ID | Hs.567359 |
|---|---|
| Mm.37531 | |
| Rn.40979 |
| KEGG ID | hsa:7518 |
|---|---|
| mmu:108138 | |
| rno:309995 |
| Swiss-Prot Accession | Q13426 |
|---|---|
| Q7Z763 | |
| Q924T3 | |
| Q5XI44 | |
| A8K3X4 | |
| Q9BS72 | |
| Q9UP94 | |
| Q8BKC9 | |
| Q8BU02 | |
| Q9D6U6 |
| GO ID | 0003677 |
|---|---|
| 0016874 | |
| 0008022 | |
| 0051103 | |
| 0006281 | |
| 0033077 | |
| 0071285 | |
| 0007417 | |
| 0006302 | |
| 0006303 | |
| 0033152 | |
| 0001701 | |
| 0045190 | |
| 0043524 | |
| 0048146 | |
| 0051351 | |
| 0050769 | |
| 0002328 | |
| 0010165 | |
| 0010332 | |
| 0016032 | |
| 0032807 | |
| 0005958 | |
| 0000793 | |
| 0005829 | |
| 0070419 | |
| 0005654 | |
| 0005634 | |
| 0006266 | |
| 0006310 | |
| 0033151 | |
| 0006974 | |
| 0010212 |
| Swiss-Prot ID | XRCC4_HUMAN |
|---|---|
| XRCC4_MOUSE |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00007672 |
|---|---|
| IPI00019678 | |
| IPI00401064 | |
| IPI00403043 | |
| IPI00403044 |
| Mouse chromosome position | 13 |
|---|
| Rat chromosome position | 2q12 |
|---|
| Homologene ID | 2555 |
|---|
| MGI ID | 1333799 |
|---|
| RGD ID | 1359573 |
|---|
| Primary Cell Localization | Nucleus |
|---|