Protein Xrcc6

URN	urn:agi-llid:2547
Total Entities	0
Connectivity	364
Name	Xrcc6
Description	X-ray repair complementing defective repair in Chinese hamster cells 6
Notes	The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]

Ariadne Ontology	DNA repair
	Biofluids assayable substances

GO Molecular Function	catalytic activity
	protein C-terminus binding
	nucleotide binding
	ATP binding
	nucleic acid binding
	DNA binding
	double-stranded telomeric DNA binding
	double-stranded DNA binding
	transcription regulatory region DNA binding
	lyase activity
	hydrolase activity
	helicase activity
	ATP-dependent DNA helicase activity
	5'-deoxyribose-5-phosphate lyase activity

GO Cellular Component	membrane
	Ku70:Ku80 complex
	DNA-dependent protein kinase-DNA ligase 4 complex
	nucleoplasm
	nucleolus
	transcription factor complex
	nuclear telomere cap complex
	protein complex
	nonhomologous end joining complex
	cytoplasm
	chromosome
	nucleus

GO Biological Process	metabolic process
	viral reproduction
	positive regulation of transcription, DNA-dependent
	positive regulation of transcription from RNA polymerase II promoter
	negative regulation of transcription, DNA-dependent
	regulation of transcription, DNA-dependent
	positive regulation of neurogenesis
	transcription, DNA-dependent
	DNA repair
	DNA ligation
	DNA recombination
	telomere maintenance
	double-strand break repair
	double-strand break repair via nonhomologous end joining
	V(D)J recombination
	response to DNA damage stimulus
	cellular hyperosmotic salinity response
	cellular response to X-ray
	response to ionizing radiation
	brain development

Pathway	Telomere Maintenance
	Cell Cycle
	Double Strand DNA Non-Homologous Repair
	non-homologous end joining pathway of double-strand break repair

Group	DNA repair
	metabolic process
	viral reproduction
	positive regulation of transcription, DNA-dependent
	positive regulation of transcription from RNA polymerase II promoter
	negative regulation of transcription, DNA-dependent
	regulation of transcription, DNA-dependent
	positive regulation of neurogenesis
	transcription, DNA-dependent
	DNA repair
	DNA ligation
	DNA recombination
	telomere maintenance
	double-strand break repair
	double-strand break repair via nonhomologous end joining
	V(D)J recombination
	response to DNA damage stimulus
	cellular hyperosmotic salinity response
	cellular response to X-ray
	response to ionizing radiation
	brain development
	catalytic activity
	protein C-terminus binding
	nucleotide binding
	ATP binding
	nucleic acid binding
	DNA binding
	double-stranded telomeric DNA binding
	double-stranded DNA binding
	transcription regulatory region DNA binding
	lyase activity
	hydrolase activity
	helicase activity
	ATP-dependent DNA helicase activity
	5'-deoxyribose-5-phosphate lyase activity
	membrane
	Ku70:Ku80 complex
	DNA-dependent protein kinase-DNA ligase 4 complex
	nucleoplasm
	nucleolus
	transcription factor complex
	nuclear telomere cap complex
	protein complex
	nonhomologous end joining complex
	cytoplasm
	chromosome
	nucleus
	Biofluids assayable substances

MedScan ID	2547

Hugo ID	4055

Human chromosome position	22q13.2

Alias	ML8
	KU70
	TLAA
	CTC75
	CTCBF
	G22P1
	CTA-216E10.7
	X-ray repair cross-complementing protein 6
	5'-dRP lyase Ku70
	Ku autoantigen, 70kDa
	DNA repair protein XRCC6
	Ku autoantigen p70 subunit
	70 kDa subunit of Ku antigen
	thyroid-lupus autoantigen p70
	lupus Ku autoantigen protein p70
	5'-deoxyribose-5-phosphate lyase Ku70
	CTC box binding factor 75 kDa subunit
	CTC box-binding factor 75 kDa subunit
	thyroid autoantigen 70kD (Ku antigen)
	ATP-dependent DNA helicase 2 subunit 1
	thyroid autoantigen 70kDa (Ku antigen)
	ATP-dependent DNA helicase II 70 kDa subunit
	ATP-dependent DNA helicase II, 70 kDa subunit
	70kDa
	Ku p70
	5'-dRP/AP lyase Ku70
	thyroid autoantigen 70 kDa
	ku autoantigen protein p70 homolog
	Kup70
	thyroid autoantigen
	Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa)
	OTTHUMP00000199334
	OTTHUMP00000199333
	OTTHUMP00000028581
	OTTHUMP00000199335
	ku70 dna-binding component of dna-dependent proteinkinase complex
	LOC94359
	X-ray repair complementing defective repair in Chinese hamster cells 6
	Xrcc6
	D22S671
	thyroid autoantigen 70kd
	70 kDa thyroid autoantigen
	D22S731
	DNA-binding component of DNA-dependentkinase complex
	G22p I
	Ku antigen

OMIM ID	152690

EC Number	3.6.4.-
	4.2.99.-

Swiss-Prot ID	XRCC6_MOUSE
	XRCC6_HUMAN

Cell Localization	Nucleus
	Chromosome

IPI ID	IPI00132424
	IPI00644712

Mouse chromosome position	15 47.5 cM

Rat chromosome position	7q34

Homologene ID	37483

MGI ID	95606

RGD ID	2643

Primary Cell Localization	Nucleus