Protein Rad51

URN	urn:agi-llid:5888
Total Entities	0
Connectivity	718
Name	Rad51
Description	RAD51 homolog (S. cerevisiae)
Notes	The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Ariadne Ontology	DNA recombination
	Secreted proteins

GO Molecular Function	protein C-terminus binding
	nucleotide binding
	ATP binding
	DNA binding
	damaged DNA binding
	double-stranded DNA binding
	single-stranded DNA binding
	nucleoside-triphosphatase activity
	DNA-dependent ATPase activity
	single-stranded DNA-dependent ATPase activity

GO Cellular Component	nucleoplasm
	PML body
	condensed nuclear chromosome
	lateral element
	synaptonemal complex
	mitochondrial matrix
	cytoplasm
	perinuclear region of cytoplasm
	mitochondrion
	condensed chromosome
	nucleus

GO Biological Process	reciprocal meiotic recombination
	meiosis
	positive regulation of DNA ligation
	DNA metabolic process
	DNA repair
	DNA recombination
	double-strand break repair
	double-strand break repair via homologous recombination
	mitotic recombination
	DNA unwinding involved in replication
	response to DNA damage stimulus
	DNA recombinase assembly
	response to drug
	protein homooligomerization

Pathway	Double Strand DNA Homologous Repair
	TGFB1-ACVRL1 Expression Targets
	homologous recombination pathway of double-strand break repair

Group	DNA recombination
	reciprocal meiotic recombination
	meiosis
	positive regulation of DNA ligation
	DNA metabolic process
	DNA repair
	DNA recombination
	double-strand break repair
	double-strand break repair via homologous recombination
	mitotic recombination
	DNA unwinding involved in replication
	response to DNA damage stimulus
	DNA recombinase assembly
	response to drug
	protein homooligomerization
	protein C-terminus binding
	nucleotide binding
	ATP binding
	DNA binding
	damaged DNA binding
	double-stranded DNA binding
	single-stranded DNA binding
	nucleoside-triphosphatase activity
	DNA-dependent ATPase activity
	single-stranded DNA-dependent ATPase activity
	nucleoplasm
	PML body
	condensed nuclear chromosome
	lateral element
	synaptonemal complex
	mitochondrial matrix
	cytoplasm
	perinuclear region of cytoplasm
	mitochondrion
	condensed chromosome
	nucleus
	Secreted proteins

MedScan ID	5888

Hugo ID	9817

Human chromosome position	15q15.1

Alias	RECA
	BRCC5
	MRMV2
	HRAD51
	RAD51A
	HsRad51
	HsT16930
	DNA repair protein RAD51 homolog 1
	RAD51 homolog A
	RecA-like protein
	recombination protein A
	RecA, E. coli, homolog of
	RAD51 homolog (RecA homolog, E. coli)
	BRCA1/BRCA2-containing complex, subunit 5
	AV304093
	RP23-15I21.4
	RGD1563603
	RAD51 homolog protein isoform 1
	RAD51/DMC1
	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)
	RAD51 homolog (S. cerevisiae)
	RAD51 homolog protein isoform 2
	RAD51, S.cerevisiae, homolog of A
	RecA-like
	DNA repair homolog I
	RAD51 homolog protein isoform II
	RAD51 homolog
	DNA repair homolog 1
	DNA repair protein RAD51 homolog I
	DNA-recombinase
	OTTMUSP00000016772
	OTTMUSP00000044872
	RA51
	RA51_HUMAN
	Rad51

PIR ID	I58295
	A48221

Swiss-Prot ID	RAD51_HUMAN
	RAD51_MOUSE

Mouse chromosome position	2 66.8 cM

Rat chromosome position	3q35

Homologene ID	2155

MGI ID	97890

RGD ID	1563603

Primary Cell Localization	Nucleus