| URN | urn:agi-llid:1763 |
|---|---|
| Total Entities | 0 |
| Connectivity | 2 |
| Name | Dna2 |
| Description | DNA replication helicase 2 homolog (yeast) |
| Notes | DNA2 is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability (Duxin et al., 2009 [PubMed 19487465]).[supplied by OMIM, Nov 2010] |
| GO Molecular Function | catalytic activity |
|---|---|
| nucleotide binding | |
| ATP binding | |
| DNA binding | |
| metal ion binding | |
| iron-sulfur cluster binding | |
| 4 iron, 4 sulfur cluster binding | |
| hydrolase activity | |
| nuclease activity | |
| endonuclease activity | |
| site-specific endodeoxyribonuclease activity, specific for altered base | |
| 5'-flap endonuclease activity | |
| ATPase activity | |
| helicase activity | |
| single-stranded DNA-dependent ATPase activity | |
| DNA helicase activity | |
| 5'-3' DNA helicase activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| gamma DNA polymerase complex | |
| mitochondrial nucleoid | |
| mitochondrion | |
| nucleus |
| GO Biological Process | metabolic process |
|---|---|
| DNA replication checkpoint | |
| S phase of mitotic cell cycle | |
| mitotic cell cycle | |
| positive regulation of DNA replication | |
| ATP catabolic process | |
| DNA replication, removal of RNA primer | |
| DNA double-strand break processing | |
| DNA repair | |
| telomere maintenance | |
| DNA replication, Okazaki fragment processing | |
| DNA replication | |
| base-excision repair | |
| mitochondrial DNA repair | |
| telomere maintenance via recombination | |
| telomere maintenance via semi-conservative replication | |
| mitochondrial DNA replication | |
| DNA duplex unwinding | |
| DNA strand elongation involved in DNA replication | |
| response to DNA damage stimulus |
| Pathway | DNA Replication |
|---|---|
| homologous recombination pathway of double-strand break repair |
| Group | metabolic process |
|---|---|
| DNA replication checkpoint | |
| S phase of mitotic cell cycle | |
| mitotic cell cycle | |
| positive regulation of DNA replication | |
| ATP catabolic process | |
| DNA replication, removal of RNA primer | |
| DNA double-strand break processing | |
| DNA repair | |
| telomere maintenance | |
| DNA replication, Okazaki fragment processing | |
| DNA replication | |
| base-excision repair | |
| mitochondrial DNA repair | |
| telomere maintenance via recombination | |
| telomere maintenance via semi-conservative replication | |
| mitochondrial DNA replication | |
| DNA duplex unwinding | |
| DNA strand elongation involved in DNA replication | |
| response to DNA damage stimulus | |
| catalytic activity | |
| nucleotide binding | |
| ATP binding | |
| DNA binding | |
| metal ion binding | |
| iron-sulfur cluster binding | |
| 4 iron, 4 sulfur cluster binding | |
| hydrolase activity | |
| nuclease activity | |
| endonuclease activity | |
| site-specific endodeoxyribonuclease activity, specific for altered base | |
| 5'-flap endonuclease activity | |
| ATPase activity | |
| helicase activity | |
| single-stranded DNA-dependent ATPase activity | |
| DNA helicase activity | |
| 5'-3' DNA helicase activity | |
| nucleoplasm | |
| gamma DNA polymerase complex | |
| mitochondrial nucleoid | |
| mitochondrion | |
| nucleus |
| MedScan ID | 1763 |
|---|---|
| 616622 |
| Hugo ID | 2939 |
|---|
| Human chromosome position | 10q21.3-q22.1 |
|---|
| LocusLink ID | 1763 |
|---|---|
| 327762 | |
| 309762 | |
| 687919 |
| Alias | DNA2L |
|---|---|
| hDNA2 | |
| RP11-9E13.1 | |
| DNA replication ATP-dependent helicase/nuclease DNA2 | |
| DNA2-like helicase | |
| DNA replication ATP-dependent helicase-like homolog | |
| E130315B21Rik | |
| DNA replication helicase 2 homolog (yeast) | |
| KIAA0083 | |
| OTTHUMP00000019702 | |
| E130315B21 | |
| LOC216023 | |
| LOC309762 | |
| mKIAA0083 | |
| DNA2-like homolog | |
| MGC133297 | |
| DNA replication helicase 2 homolog | |
| DNA replication helicase-like homolog | |
| DNA2 (DNA replication helicase, , homolog)-like | |
| DNA2 (DNA replication helicase, yeast, homolog)-like | |
| DNA2 DNA replication helicase 2-like | |
| DNA2 DNA replication helicase 2-like (yeast) | |
| OTTMUSP00000040134 | |
| LOC687919 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601810 |
|---|
| Unigene ID | Hs.532446 |
|---|---|
| Mm.21492 |
| KEGG ID | hsa:1763 |
|---|---|
| mmu:327762 | |
| rno:309762 |
| Swiss-Prot Accession | P51530 |
|---|---|
| Q6ZQJ5 | |
| D3ZG52 | |
| Q2NKM1 | |
| Q5TC49 | |
| Q5TC50 | |
| Q6P455 | |
| Q6PI80 | |
| Q7Z6H9 | |
| Q8N346 | |
| Q14BM9 | |
| Q8BSZ0 | |
| Q8R3J3 |
| EC Number | 3.6.4.12 |
|---|---|
| 3.1.-.- |
| GO ID | 0051539 |
|---|---|
| 0043139 | |
| 0017108 | |
| 0005524 | |
| 0016887 | |
| 0003677 | |
| 0003678 | |
| 0004386 | |
| 0046872 | |
| 0004518 | |
| 0043142 | |
| 0016890 | |
| 0006200 | |
| 0000729 | |
| 0032508 | |
| 0006260 | |
| 0000076 | |
| 0033567 | |
| 0043137 | |
| 0006271 | |
| 0000084 | |
| 0006284 | |
| 0043504 | |
| 0006264 | |
| 0000278 | |
| 0045740 | |
| 0000723 | |
| 0000722 | |
| 0032201 | |
| 0005760 | |
| 0042645 | |
| 0005654 | |
| 0005634 | |
| 0003824 | |
| 0004519 | |
| 0016787 | |
| 0051536 | |
| 0000166 | |
| 0006281 | |
| 0008152 | |
| 0006974 | |
| 0005739 |
| PIR ID | T50697 |
|---|
| Swiss-Prot ID | DNA2_HUMAN |
|---|---|
| DNA2_MOUSE |
| Cell Localization | Nucleus |
|---|---|
| Mitochondrion |
| IPI ID | IPI00216142 |
|---|---|
| IPI00816670 | |
| IPI00816801 | |
| IPI00224915 | |
| IPI00816966 |
| Mouse chromosome position | 10 |
|---|
| Rat chromosome position | 20p11 |
|---|
| Homologene ID | 6124 |
|---|
| MGI ID | 2443732 |
|---|
| RGD ID | 1306791 |
|---|