| URN | urn:agi-llid:10646 |
|---|---|
| Total Entities | 0 |
| Connectivity | 41 |
| Name | Rad54b |
| Description | RAD54 homolog B (S. cerevisiae) |
| Notes | The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Glucose metabolism |
|---|---|
| DNA recombination | |
| DNA repair | |
| Transcription factors |
| GO Molecular Function | ATP binding |
|---|---|
| DNA translocase activity | |
| helicase activity | |
| DNA helicase activity | |
| RNA helicase activity |
| GO Cellular Component | nucleus |
|---|
| GO Biological Process | reciprocal meiotic recombination |
|---|---|
| ATP catabolic process | |
| DNA repair | |
| double-strand break repair via homologous recombination | |
| mitotic recombination | |
| DNA duplex unwinding | |
| response to DNA damage stimulus | |
| response to drug | |
| response to ionizing radiation |
| Pathway | homologous recombination pathway of double-strand break repair |
|---|
| Group | Glucose metabolism |
|---|---|
| DNA recombination | |
| DNA repair | |
| Transcription factors | |
| reciprocal meiotic recombination | |
| ATP catabolic process | |
| DNA repair | |
| double-strand break repair via homologous recombination | |
| mitotic recombination | |
| DNA duplex unwinding | |
| response to DNA damage stimulus | |
| response to drug | |
| response to ionizing radiation | |
| ATP binding | |
| DNA translocase activity | |
| helicase activity | |
| DNA helicase activity | |
| RNA helicase activity | |
| nucleus |
| MedScan ID | 10646 |
|---|---|
| 631487 |
| Hugo ID | 17228 |
|---|
| Human chromosome position | 8q22.1 |
|---|
| LocusLink ID | 10646 |
|---|---|
| 25788 | |
| 623474 | |
| 313063 | |
| 100128414 |
| Alias | RDH54 |
|---|---|
| hCG_2009220 | |
| DNA repair and recombination protein RAD54B | |
| E130016E03Rik | |
| RP23-242O9.3 | |
| Fsbp | |
| RGD1306507 | |
| fibrinogen silencer-binding protein | |
| RAD54, S. cerevisiae, homolog of, B | |
| RAD54 homolog B | |
| RAD54 homolog B (S. cerevisiae) | |
| RAD54B | |
| RAD54B homolog | |
| RAD54B homolog, isoform 1 | |
| RAD54B homolog, isoform I | |
| OTTMUSP00000004870 | |
| LOC633073 | |
| fibrinogen silencer binding protein, homolog (human) | |
| LOC730560 | |
| MGC67261 | |
| E130016E03 | |
| fibrinogen silencer binding protein, homolog | |
| homolog of yeast RAD54, B | |
| LOC728025 | |
| fibrinogen silencer binding protein | |
| LOC100128414 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 604289 |
|---|---|
| 114500 |
| Unigene ID | Hs.30561 |
|---|---|
| Hs.657457 | |
| Mm.249437 | |
| Rn.214081 |
| KEGG ID | hsa:25788 |
|---|---|
| mmu:623474 | |
| rno:313063 |
| Swiss-Prot Accession | F6WBS8 |
|---|---|
| O95073 | |
| Q9Y620 | |
| Q6PFE3 | |
| Q8BKE5 | |
| D3ZXW3 | |
| A2AIV0 |
| EC Number | 3.6.4.- |
|---|
| GO ID | 0005524 |
|---|---|
| 0003678 | |
| 0015616 | |
| 0003724 | |
| 0032508 | |
| 0000724 | |
| 0006312 | |
| 0007131 | |
| 0005634 | |
| 0006200 | |
| 0006974 | |
| 0042493 | |
| 0010212 | |
| 0004386 | |
| 0006281 |
| Swiss-Prot ID | RA54B_MOUSE |
|---|---|
| RA54B_HUMAN |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| IPI ID | IPI00420855 |
|---|---|
| IPI00018281 |
| Mouse chromosome position | 4 |
|---|
| Rat chromosome position | 5q13 |
|---|
| Homologene ID | 8240 |
|---|
| MGI ID | 3605986 |
|---|
| RGD ID | 1306507 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|---|
| Nucleus |