| URN | urn:agi-llid:5932 |
|---|---|
| Total Entities | 0 |
| Connectivity | 66 |
| Name | Rbbp8 |
| Description | retinoblastoma binding protein 8 |
| Notes | The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | RNA polymerase II repressing transcription factor binding |
|---|---|
| DNA binding | |
| damaged DNA binding | |
| hydrolase activity | |
| nuclease activity | |
| endonuclease activity | |
| single-stranded DNA specific endodeoxyribonuclease activity | |
| RNA polymerase II transcription corepressor activity |
| GO Cellular Component | transcriptional repressor complex |
|---|---|
| nucleus |
| GO Biological Process | cell division |
|---|---|
| cell cycle | |
| G1-S transition of mitotic cell cycle | |
| cell cycle checkpoint | |
| G2-M transition DNA damage checkpoint | |
| mitosis | |
| meiosis | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription from RNA polymerase II promoter | |
| DNA double-strand break processing involved in repair via single-strand annealing | |
| nucleic acid phosphodiester bond hydrolysis | |
| DNA repair | |
| double-strand break repair via homologous recombination | |
| response to DNA damage stimulus | |
| blastocyst hatching |
| Pathway | Double Strand DNA Homologous Repair |
|---|---|
| ataxia telangiectasia-mutated (ATM) signaling pathway | |
| homologous recombination pathway of double-strand break repair |
| Group | cell division |
|---|---|
| cell cycle | |
| G1-S transition of mitotic cell cycle | |
| cell cycle checkpoint | |
| G2-M transition DNA damage checkpoint | |
| mitosis | |
| meiosis | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription from RNA polymerase II promoter | |
| DNA double-strand break processing involved in repair via single-strand annealing | |
| nucleic acid phosphodiester bond hydrolysis | |
| DNA repair | |
| double-strand break repair via homologous recombination | |
| response to DNA damage stimulus | |
| blastocyst hatching | |
| RNA polymerase II repressing transcription factor binding | |
| DNA binding | |
| damaged DNA binding | |
| hydrolase activity | |
| nuclease activity | |
| endonuclease activity | |
| single-stranded DNA specific endodeoxyribonuclease activity | |
| RNA polymerase II transcription corepressor activity | |
| transcriptional repressor complex | |
| nucleus |
| MedScan ID | 5932 |
|---|---|
| 347729 |
| Hugo ID | 9891 |
|---|
| Human chromosome position | 18q11.2 |
|---|
| LocusLink ID | 5932 |
|---|---|
| 225182 | |
| 291787 | |
| 347729 |
| Alias | RIM |
|---|---|
| CTIP | |
| JWDS | |
| SAE2 | |
| SCKL2 | |
| DNA endonuclease RBBP8 | |
| RBBP-8 | |
| CTBP-interacting protein | |
| sporulation in the absence of SPO11 protein 2 homolog | |
| 9930104E21Rik | |
| retinoblastoma-binding protein 8 | |
| RGD1308872 | |
| rCG_41266 | |
| CTBP-interactive protein CtIP | |
| Retinoblastoma-interactive protein and myosin-like | |
| retinoblastoma-interactive myosin-like | |
| Retinoblastoma-interacting protein and myosin-like | |
| retinoblastoma-interacting myosin-like | |
| retinoblastoma binding protein VIII | |
| retinoblastoma binding protein 8 | |
| CtBP interacting protein | |
| HGCN | |
| RBBP8 | |
| CtBP interactive protein | |
| CTBP-interacting protein CtIP | |
| OTTHUMP00000162575 | |
| 9930104E21 | |
| Seckel syndrome 2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 604124 |
|---|---|
| 251255 | |
| 606744 |
| Unigene ID | Hs.546282 |
|---|---|
| Mm.154275 | |
| Rn.128724 |
| KEGG ID | hsa:5932 |
|---|---|
| mmu:225182 | |
| rno:291787 |
| Swiss-Prot Accession | Q99708 |
|---|---|
| A6NKN2 | |
| Q80YR6 | |
| B1WC58 | |
| A8K8W6 | |
| E7ETY1 | |
| O75371 | |
| Q8NHQ3 |
| EC Number | 3.1.-.- |
|---|
| GO ID | 0001103 |
|---|---|
| 0001106 | |
| 0003684 | |
| 0000014 | |
| 0010792 | |
| 0006281 | |
| 0000082 | |
| 0031572 | |
| 0001835 | |
| 0000075 | |
| 0051301 | |
| 0000724 | |
| 0007126 | |
| 0007067 | |
| 0000122 | |
| 0006357 | |
| 0005634 | |
| 0017053 | |
| 0003677 | |
| 0004519 | |
| 0016787 | |
| 0004518 | |
| 0007049 | |
| 0090305 | |
| 0006974 |
| Swiss-Prot ID | COM1_MOUSE |
|---|---|
| COM1_RAT | |
| COM1_HUMAN |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00342157 |
|---|---|
| IPI00363470 | |
| IPI00480111 |
| Mouse chromosome position | 18 |
|---|
| Rat chromosome position | 18p13 |
|---|
| Homologene ID | 28546 |
|---|
| MGI ID | 2442995 |
|---|
| RGD ID | 1308872 |
|---|