| URN | urn:agi-llid:8571 |
|---|---|
| Total Entities | 0 |
| Connectivity | 151 |
| Name | Exo1 |
| Description | exonuclease 1 |
| Notes | This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | DNA recombination |
|---|---|
| DNA repair | |
| Secreted proteins |
| GO Molecular Function | catalytic activity |
|---|---|
| DNA binding | |
| structure-specific DNA binding | |
| metal ion binding | |
| hydrolase activity | |
| hydrolase activity, acting on ester bonds | |
| nuclease activity | |
| exonuclease activity | |
| endonuclease activity | |
| ribonuclease H activity | |
| flap endonuclease activity | |
| 5'-3' exodeoxyribonuclease activity | |
| single-stranded DNA specific 5'-3' exodeoxyribonuclease activity | |
| double-stranded DNA specific 5'-3' exodeoxyribonuclease activity | |
| 5'-3' exonuclease activity |
| GO Cellular Component | nucleus |
|---|
| GO Biological Process | meiosis |
|---|---|
| isotype switching | |
| nucleobase-containing compound metabolic process | |
| DNA repair | |
| DNA recombination | |
| mismatch repair | |
| response to DNA damage stimulus | |
| humoral immune response mediated by circulating immunoglobulin | |
| somatic hypermutation of immunoglobulin genes |
| Pathway | Single-Strand Mismatch DNA Repair |
|---|---|
| homologous recombination pathway of double-strand break repair |
| Group | DNA recombination |
|---|---|
| DNA repair | |
| meiosis | |
| isotype switching | |
| nucleobase-containing compound metabolic process | |
| DNA repair | |
| DNA recombination | |
| mismatch repair | |
| response to DNA damage stimulus | |
| humoral immune response mediated by circulating immunoglobulin | |
| somatic hypermutation of immunoglobulin genes | |
| catalytic activity | |
| DNA binding | |
| structure-specific DNA binding | |
| metal ion binding | |
| hydrolase activity | |
| hydrolase activity, acting on ester bonds | |
| nuclease activity | |
| exonuclease activity | |
| endonuclease activity | |
| ribonuclease H activity | |
| flap endonuclease activity | |
| 5'-3' exodeoxyribonuclease activity | |
| single-stranded DNA specific 5'-3' exodeoxyribonuclease activity | |
| double-stranded DNA specific 5'-3' exodeoxyribonuclease activity | |
| 5'-3' exonuclease activity | |
| nucleus | |
| Secreted proteins |
| MedScan ID | 8571 |
|---|
| Hugo ID | 3511 |
|---|
| Human chromosome position | 1q42-q43 |
|---|
| LocusLink ID | 8571 |
|---|---|
| 9156 | |
| 26909 | |
| 305000 |
| Alias | HEX1 |
|---|---|
| hExoI | |
| RP11-553N16.2 | |
| exonuclease 1 | |
| hExo1 | |
| rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1 | |
| Msa | |
| 5730442G03Rik | |
| mExo1 | |
| exonuclease I | |
| rad2 nuclease family member, homolog of S. cerevisiae exonuclease I | |
| homolog of S. cerevisiae exonuclease 1 | |
| OTTHUMP00000037878 | |
| OTTHUMP00000037879 | |
| Probable serine protease HTRA4 | |
| Probable serine proteinase HTRA4 | |
| 5730442G03 | |
| 5'-3' exonuclease HEX1 | |
| EXO I | |
| EXO1 | |
| EXO1A | |
| HEX I | |
| 5'-3' exonuclease HEX I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606063 |
|---|
| Unigene ID | Hs.498248 |
|---|---|
| Mm.283046 | |
| Rn.52638 |
| KEGG ID | hsa:9156 |
|---|---|
| mmu:26909 | |
| rno:305000 |
| Swiss-Prot Accession | Q9UQ84 |
|---|---|
| Q9QZ11 | |
| Q3TLM4 | |
| Q923A5 | |
| O60545 | |
| O75214 | |
| O75466 | |
| Q5T396 | |
| Q96IJ1 | |
| Q9UG38 | |
| Q9UNW0 |
| EC Number | 3.1.-.- |
|---|
| GO ID | 0035312 |
|---|---|
| 0008409 | |
| 0003677 | |
| 0051908 | |
| 0004527 | |
| 0048256 | |
| 0046872 | |
| 0004523 | |
| 0045145 | |
| 0043566 | |
| 0006310 | |
| 0006281 | |
| 0002455 | |
| 0045190 | |
| 0007126 | |
| 0006298 | |
| 0016446 | |
| 0005634 | |
| 0003824 | |
| 0004519 | |
| 0016787 | |
| 0016788 | |
| 0004518 | |
| 0006139 | |
| 0006974 |
| PIR ID | T12524 |
|---|
| Swiss-Prot ID | EXO1_MOUSE |
|---|---|
| EXO1_HUMAN |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00331190 |
|---|---|
| IPI00219173 | |
| IPI00556476 |
| Mouse chromosome position | 1 97.0 cM |
|---|
| Rat chromosome position | 13q25 |
|---|
| Homologene ID | 31352 |
|---|
| MGI ID | 1349427 |
|---|
| RGD ID | 1309465 |
|---|
| Primary Cell Localization | Nucleus |
|---|