| URN | urn:agi-llid:4040 |
|---|---|
| Total Entities | 0 |
| Connectivity | 264 |
| Name | Lrp6 |
| Description | low density lipoprotein receptor-related protein 6 |
| Notes | LRP6 may function as a potential oncogenic protein by modulating Wnt/beta-catenin signaling LRP6 may function as a potential oncogenic protein by modulating Wnt/beta-catenin signaling. SOST antagonizes Wnt signaling by binding to the extracellular domain of the Wnt coreceptors LRP5 and LRP6 and disrupting Wnt-induced Frizzled-LRP complex formation. Wnt canonical signaling through LRP6 establishes a novel mechanism for receptor activation which is opposite to the general paradigm of ligand-induced receptor oligomerization. Role for an LDL receptor-related protein in the regulation of vascular smooth muscle cell proliferation and survival through the evolutionary conserved Wnt signaling cascade. |
| Ariadne Ontology | FZD |
|---|---|
| Secreted proteins |
| GO Molecular Function | receptor binding |
|---|---|
| apolipoprotein binding | |
| Wnt-protein binding | |
| frizzled binding | |
| protein homodimerization activity | |
| kinase inhibitor activity | |
| coreceptor activity | |
| Wnt-activated receptor activity | |
| coreceptor activity involved in Wnt receptor signaling pathway | |
| low-density lipoprotein receptor activity | |
| toxin transporter activity |
| GO Cellular Component | membrane |
|---|---|
| synapse | |
| caveola | |
| integral to membrane | |
| receptor complex | |
| plasma membrane | |
| cell surface | |
| cytoplasmic vesicle | |
| endoplasmic reticulum | |
| early endosome | |
| neuronal cell body |
| GO Biological Process | positive regulation of cell cycle |
|---|---|
| synaptic transmission | |
| negative regulation of Wnt receptor signaling pathway | |
| negative regulation of non-canonical Wnt receptor signaling pathway | |
| negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis | |
| negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis | |
| negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis | |
| negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis | |
| negative regulation of planar cell polarity pathway involved in pericardium morphogenesis | |
| negative regulation of planar cell polarity pathway involved in neural tube closure | |
| positive regulation of canonical Wnt receptor signaling pathway | |
| positive regulation of Wnt receptor signaling pathway involved in dorsal-ventral axis specification | |
| regulation of cell proliferation | |
| Wnt receptor signaling pathway | |
| canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development | |
| canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation | |
| Wnt receptor signaling pathway involved in dorsal-ventral axis specification | |
| Wnt receptor signaling pathway involved in forebrain neuroblast division | |
| canonical Wnt receptor signaling pathway | |
| Wnt receptor signaling pathway involved in somitogenesis | |
| canonical Wnt receptor signaling pathway involved in regulation of cell proliferation | |
| canonical Wnt receptor signaling pathway involved in neural crest cell differentiation | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of protein phosphorylation | |
| negative regulation of protein kinase activity | |
| negative regulation of protein serine-threonine kinase activity | |
| regulation of transcription, DNA-dependent | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of fat cell differentiation | |
| negative regulation of epithelial cell proliferation | |
| negative regulation of smooth muscle cell apoptotic process | |
| positive regulation of mesenchymal cell proliferation | |
| positive regulation of apoptotic process | |
| regulation of cell development | |
| regulation of fat cell differentiation | |
| formation of radial glial scaffolds | |
| neural crest formation | |
| dopaminergic neuron differentiation | |
| neural crest cell differentiation | |
| forebrain radial glial cell differentiation | |
| generation of neurons | |
| forebrain generation of neurons | |
| cell-cell adhesion | |
| elevation of cytosolic calcium ion concentration | |
| cell migration involved in gastrulation | |
| cerebral cortex cell migration | |
| cellular response to cholesterol | |
| response to folic acid | |
| response to peptide hormone stimulus | |
| regulation of ossification | |
| positive regulation of ossification | |
| positive regulation of bone resorption | |
| multicellular organismal development | |
| external genitalia morphogenesis | |
| embryonic digit morphogenesis | |
| embryonic camera-type eye morphogenesis | |
| retina morphogenesis in camera-type eye | |
| cerebellum morphogenesis | |
| heart looping | |
| embryonic retina morphogenesis in camera-type eye | |
| bone morphogenesis | |
| primitive streak formation | |
| mammary gland duct morphogenesis | |
| somitogenesis | |
| face morphogenesis | |
| branching involved in mammary gland duct morphogenesis | |
| mammary placode formation | |
| axis elongation | |
| axis elongation involved in somitogenesis | |
| trachea cartilage morphogenesis | |
| neural tube closure | |
| forebrain development | |
| midbrain development | |
| cerebral cortex development | |
| palate development | |
| midbrain-hindbrain boundary development | |
| neural tube development | |
| thalamus development | |
| embryonic pattern specification | |
| dorsal-ventral axis specification | |
| anterior-posterior pattern specification | |
| post-anal tail morphogenesis | |
| pericardium morphogenesis | |
| gastrulation with mouth forming second | |
| embryonic limb morphogenesis | |
| embryonic forelimb morphogenesis | |
| embryonic hindlimb morphogenesis | |
| morphogenesis of an epithelium | |
| convergent extension | |
| skeletal system morphogenesis | |
| odontogenesis of dentin-containing tooth | |
| limb morphogenesis | |
| bone remodeling | |
| endocytosis | |
| receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport |
| Pathway | FrizzledR -> CTNNB signaling |
|---|---|
| Dexamethasone-Induced Neurotoxicity | |
| Dexamethasone-Induced Diabetes | |
| Dexamethasone-Induced Osteoporosis | |
| Canonical WNT Signaling Expression Targets | |
| WNT9B Expression Targets | |
| WNT9A Expression Targets | |
| Wnt signaling, canonical pathway | |
| altered Wnt signaling, canonical pathway | |
| canonical Wnt signaling pathway | |
| Wnt signaling, canonical pathway |
| Group | FZD |
|---|---|
| positive regulation of cell cycle | |
| synaptic transmission | |
| negative regulation of Wnt receptor signaling pathway | |
| negative regulation of non-canonical Wnt receptor signaling pathway | |
| negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis | |
| negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis | |
| negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis | |
| negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis | |
| negative regulation of planar cell polarity pathway involved in pericardium morphogenesis | |
| negative regulation of planar cell polarity pathway involved in neural tube closure | |
| positive regulation of canonical Wnt receptor signaling pathway | |
| positive regulation of Wnt receptor signaling pathway involved in dorsal-ventral axis specification | |
| regulation of cell proliferation | |
| Wnt receptor signaling pathway | |
| canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development | |
| canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation | |
| Wnt receptor signaling pathway involved in dorsal-ventral axis specification | |
| Wnt receptor signaling pathway involved in forebrain neuroblast division | |
| canonical Wnt receptor signaling pathway | |
| Wnt receptor signaling pathway involved in somitogenesis | |
| canonical Wnt receptor signaling pathway involved in regulation of cell proliferation | |
| canonical Wnt receptor signaling pathway involved in neural crest cell differentiation | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of protein phosphorylation | |
| negative regulation of protein kinase activity | |
| negative regulation of protein serine-threonine kinase activity | |
| regulation of transcription, DNA-dependent | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of fat cell differentiation | |
| negative regulation of epithelial cell proliferation | |
| negative regulation of smooth muscle cell apoptotic process | |
| positive regulation of mesenchymal cell proliferation | |
| positive regulation of apoptotic process | |
| regulation of cell development | |
| regulation of fat cell differentiation | |
| formation of radial glial scaffolds | |
| neural crest formation | |
| dopaminergic neuron differentiation | |
| neural crest cell differentiation | |
| forebrain radial glial cell differentiation | |
| generation of neurons | |
| forebrain generation of neurons | |
| cell-cell adhesion | |
| elevation of cytosolic calcium ion concentration | |
| cell migration involved in gastrulation | |
| cerebral cortex cell migration | |
| cellular response to cholesterol | |
| response to folic acid | |
| response to peptide hormone stimulus | |
| regulation of ossification | |
| positive regulation of ossification | |
| positive regulation of bone resorption | |
| multicellular organismal development | |
| external genitalia morphogenesis | |
| embryonic digit morphogenesis | |
| embryonic camera-type eye morphogenesis | |
| retina morphogenesis in camera-type eye | |
| cerebellum morphogenesis | |
| heart looping | |
| embryonic retina morphogenesis in camera-type eye | |
| bone morphogenesis | |
| primitive streak formation | |
| mammary gland duct morphogenesis | |
| somitogenesis | |
| face morphogenesis | |
| branching involved in mammary gland duct morphogenesis | |
| mammary placode formation | |
| axis elongation | |
| axis elongation involved in somitogenesis | |
| trachea cartilage morphogenesis | |
| neural tube closure | |
| forebrain development | |
| midbrain development | |
| cerebral cortex development | |
| palate development | |
| midbrain-hindbrain boundary development | |
| neural tube development | |
| thalamus development | |
| embryonic pattern specification | |
| dorsal-ventral axis specification | |
| anterior-posterior pattern specification | |
| post-anal tail morphogenesis | |
| pericardium morphogenesis | |
| gastrulation with mouth forming second | |
| embryonic limb morphogenesis | |
| embryonic forelimb morphogenesis | |
| embryonic hindlimb morphogenesis | |
| morphogenesis of an epithelium | |
| convergent extension | |
| skeletal system morphogenesis | |
| odontogenesis of dentin-containing tooth | |
| limb morphogenesis | |
| bone remodeling | |
| endocytosis | |
| receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport | |
| receptor binding | |
| apolipoprotein binding | |
| Wnt-protein binding | |
| frizzled binding | |
| protein homodimerization activity | |
| kinase inhibitor activity | |
| coreceptor activity | |
| Wnt-activated receptor activity | |
| coreceptor activity involved in Wnt receptor signaling pathway | |
| low-density lipoprotein receptor activity | |
| toxin transporter activity | |
| membrane | |
| synapse | |
| caveola | |
| integral to membrane | |
| receptor complex | |
| plasma membrane | |
| cell surface | |
| cytoplasmic vesicle | |
| endoplasmic reticulum | |
| early endosome | |
| neuronal cell body | |
| Secreted proteins |
| MedScan ID | 4040 |
|---|---|
| 634384 |
| Hugo ID | 6698 |
|---|
| Human chromosome position | 12p13.2 |
|---|---|
| 12p13.3-p11.2 | |
| 12p11-p13 |
| LocusLink ID | 4040 |
|---|---|
| 16974 | |
| 312781 |
| Alias | ADCAD2 |
|---|---|
| low-density lipoprotein receptor-related protein 6 | |
| LRP-6 | |
| Cd | |
| Gw | |
| C030016K15Rik | |
| crooked | |
| low density lipoprotein-related protein 6 | |
| low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6 | |
| low density lipoprotein-related protein VI | |
| LOC269807 | |
| low density lipoprotein receptor-related protein 6 | |
| low density lipoprotein receptor-related protein VI | |
| LOC232429 | |
| Lrp6 | |
| OTTMUSP00000023469 | |
| LDL receptor-related protein VI | |
| C030016K15 | |
| FLJ90062 | |
| FLJ90421 | |
| LDL receptor-related protein 6 | |
| low density lipoprotein receptor-related protein 6 (predicted) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603507 |
|---|---|
| 610947 |
| Unigene ID | Hs.584775 |
|---|---|
| Hs.658913 | |
| Mm.321990 | |
| Rn.229041 | |
| Rn.32960 | |
| Hs.558539 |
| KEGG ID | hsa:4040 |
|---|---|
| mmu:16974 | |
| rno:312781 |
| Swiss-Prot Accession | O75581 |
|---|---|
| O88572 | |
| D3ZUH9 | |
| Q17RZ2 | |
| Q59EX8 | |
| Q9UQH4 | |
| Q3TS86 | |
| Q3US54 |
| GO ID | 0042813 |
|---|---|
| 0017147 | |
| 0034185 | |
| 0071936 | |
| 0005109 | |
| 0019210 | |
| 0005041 | |
| 0042803 | |
| 0005102 | |
| 0019534 | |
| 0016055 | |
| 0044332 | |
| 0021874 | |
| 0090244 | |
| 0009952 | |
| 0090245 | |
| 0060349 | |
| 0046849 | |
| 0060444 | |
| 0060070 | |
| 0061310 | |
| 0044335 | |
| 0061324 | |
| 0044340 | |
| 0042074 | |
| 0071397 | |
| 0021587 | |
| 0021795 | |
| 0021987 | |
| 0060026 | |
| 0071542 | |
| 0048596 | |
| 0042733 | |
| 0035115 | |
| 0035116 | |
| 0030326 | |
| 0009880 | |
| 0060059 | |
| 0035261 | |
| 0060325 | |
| 0021861 | |
| 0021943 | |
| 0001702 | |
| 0001947 | |
| 0060596 | |
| 0030901 | |
| 0030917 | |
| 0050680 | |
| 0045599 | |
| 2000151 | |
| 2000162 | |
| 2000168 | |
| 2000164 | |
| 2000166 | |
| 2000149 | |
| 0006469 | |
| 0001933 | |
| 0071901 | |
| 0034392 | |
| 0014033 | |
| 0014029 | |
| 0001843 | |
| 0042475 | |
| 0060021 | |
| 0003344 | |
| 2000055 | |
| 0043065 | |
| 0045780 | |
| 0090263 | |
| 0045787 | |
| 0002053 | |
| 0045778 | |
| 0051091 | |
| 0045944 | |
| 0045893 | |
| 0090009 | |
| 0090118 | |
| 0060284 | |
| 0045598 | |
| 0030278 | |
| 0051593 | |
| 0007268 | |
| 0021794 | |
| 0060535 | |
| 0005901 | |
| 0009986 | |
| 0031410 | |
| 0005769 | |
| 0005783 | |
| 0016021 | |
| 0043025 | |
| 0005886 | |
| 0043235 | |
| 0045202 | |
| 0003401 | |
| 0016337 | |
| 0009950 | |
| 0007204 | |
| 0006897 | |
| 0030900 | |
| 0021872 | |
| 0048699 | |
| 0035108 | |
| 0060603 | |
| 0002009 | |
| 0007275 | |
| 0030178 | |
| 2000051 | |
| 0021915 | |
| 0036342 | |
| 0042127 | |
| 0006355 | |
| 0060042 | |
| 0048705 | |
| 0001756 | |
| 0016020 | |
| 0015026 | |
| 0043434 | |
| 0004872 | |
| 0005624 | |
| 0035121 | |
| 0005515 | |
| 0003674 | |
| 0005575 | |
| 0010003 |
| PIR ID | JE0272 |
|---|---|
| JE0273 |
| Swiss-Prot ID | LRP6_HUMAN |
|---|---|
| LRP6_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Endoplasmic reticulum | |
| Plasma membrane |
| IPI ID | IPI00000203 |
|---|---|
| IPI00271594 | |
| IPI00831041 | |
| IPI00870584 |
| Mouse chromosome position | 6 63.8 cM |
|---|
| Rat chromosome position | 4q43 |
|---|
| Homologene ID | 1747 |
|---|
| MGI ID | 1298218 |
|---|
| RGD ID | 1304749 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|
| KEGG pathway | Wnt signaling pathway |
|---|