| URN | urn:agi-llid:6597 |
|---|---|
| Total Entities | 0 |
| Connectivity | 564 |
| Name | Smarca4 |
| Description | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
| Notes | The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Alternatively spliced transcripts have been found for this gene, but their full-length natures have not been determined. |
| Ariadne Ontology | Chromatin remodeling |
|---|---|
| Biofluids assayable substances |
| GO Molecular Function | chromatin binding |
|---|---|
| protein complex binding | |
| p53 binding | |
| transcription factor binding | |
| protein N-terminus binding | |
| Tat protein binding | |
| androgen receptor binding | |
| histone acetyl-lysine binding | |
| nucleotide binding | |
| ATP binding | |
| nucleic acid binding | |
| DNA binding | |
| RNA polymerase II regulatory region sequence-specific DNA binding | |
| hydrolase activity | |
| hydrolase activity, acting on acid anhydrides | |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
| ATPase activity | |
| helicase activity | |
| DNA-dependent ATPase activity | |
| transcription corepressor activity | |
| transcription coactivator activity |
| GO Cellular Component | nucleolus |
|---|---|
| npBAF complex | |
| nBAF complex | |
| WINAC complex | |
| SWI-SNF complex | |
| nuclear chromatin | |
| perichromatin fibrils | |
| nuclear euchromatin | |
| heterochromatin | |
| nucleus |
| GO Biological Process | positive regulation by host of viral transcription |
|---|---|
| negative regulation of S phase of mitotic cell cycle | |
| negative regulation of androgen receptor signaling pathway | |
| negative regulation of cell growth | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| methylation-dependent chromatin silencing | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| stem cell maintenance | |
| cell morphogenesis | |
| vasculogenesis | |
| keratinocyte differentiation | |
| definitive erythrocyte differentiation | |
| aortic smooth muscle cell differentiation | |
| glial cell fate determination | |
| transcription, DNA-dependent | |
| ATP catabolic process | |
| DNA methylation on cytosine within a CG sequence | |
| histone H3 acetylation | |
| nucleosome assembly | |
| nucleosome disassembly | |
| chromatin modification | |
| chromatin remodeling | |
| ATP-dependent chromatin remodeling | |
| extracellular matrix organization | |
| epidermis morphogenesis | |
| heart trabecula formation | |
| blastocyst growth | |
| forebrain development | |
| hindbrain development | |
| neural retina development | |
| nervous system development | |
| liver development | |
| heart development | |
| in utero embryonic development | |
| embryonic organ morphogenesis | |
| embryonic hindlimb morphogenesis | |
| blastocyst hatching | |
| positive regulation of DNA binding |
| Pathway | SWI/SNF BRG1/BAF Chromatin Remodeling |
|---|---|
| SWI/SNF BRG1/PBAF Chromatin Remodeling | |
| Wnt signaling, canonical pathway | |
| altered Wnt signaling, canonical pathway | |
| canonical Wnt signaling pathway | |
| Wnt signaling, canonical pathway |
| Group | Chromatin remodeling |
|---|---|
| positive regulation by host of viral transcription | |
| negative regulation of S phase of mitotic cell cycle | |
| negative regulation of androgen receptor signaling pathway | |
| negative regulation of cell growth | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| methylation-dependent chromatin silencing | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| stem cell maintenance | |
| cell morphogenesis | |
| vasculogenesis | |
| keratinocyte differentiation | |
| definitive erythrocyte differentiation | |
| aortic smooth muscle cell differentiation | |
| glial cell fate determination | |
| transcription, DNA-dependent | |
| ATP catabolic process | |
| DNA methylation on cytosine within a CG sequence | |
| histone H3 acetylation | |
| nucleosome assembly | |
| nucleosome disassembly | |
| chromatin modification | |
| chromatin remodeling | |
| ATP-dependent chromatin remodeling | |
| extracellular matrix organization | |
| epidermis morphogenesis | |
| heart trabecula formation | |
| blastocyst growth | |
| forebrain development | |
| hindbrain development | |
| neural retina development | |
| nervous system development | |
| liver development | |
| heart development | |
| in utero embryonic development | |
| embryonic organ morphogenesis | |
| embryonic hindlimb morphogenesis | |
| blastocyst hatching | |
| positive regulation of DNA binding | |
| chromatin binding | |
| protein complex binding | |
| p53 binding | |
| transcription factor binding | |
| protein N-terminus binding | |
| Tat protein binding | |
| androgen receptor binding | |
| histone acetyl-lysine binding | |
| nucleotide binding | |
| ATP binding | |
| nucleic acid binding | |
| DNA binding | |
| RNA polymerase II regulatory region sequence-specific DNA binding | |
| hydrolase activity | |
| hydrolase activity, acting on acid anhydrides | |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
| ATPase activity | |
| helicase activity | |
| DNA-dependent ATPase activity | |
| transcription corepressor activity | |
| transcription coactivator activity | |
| nucleolus | |
| npBAF complex | |
| nBAF complex | |
| WINAC complex | |
| SWI-SNF complex | |
| nuclear chromatin | |
| perichromatin fibrils | |
| nuclear euchromatin | |
| heterochromatin | |
| nucleus | |
| Biofluids assayable substances |
| MedScan ID | 6597 |
|---|
| Hugo ID | 11100 |
|---|
| Human chromosome position | 19p13.2 |
|---|
| LocusLink ID | 6597 |
|---|---|
| 20586 | |
| 171379 |
| Alias | BRG1 |
|---|---|
| SNF2 | |
| SWI2 | |
| MRD16 | |
| RTPS2 | |
| BAF190 | |
| SNF2L4 | |
| SNF2LB | |
| hSNF2b | |
| BAF190A | |
| transcription activator BRG1 | |
| SNF2-beta | |
| SNF2-like 4 | |
| protein BRG-1 | |
| nuclear protein GRB1 | |
| brahma protein-like 1 | |
| BRM/SWI2-related gene 1 | |
| homeotic gene regulator | |
| protein brahma homolog 1 | |
| BRG1-associated factor 190A | |
| sucrose nonfermenting-like 4 | |
| ATP-dependent helicase SMARCA4 | |
| mitotic growth and transcription activator | |
| global transcription activator homologous sequence | |
| SW1/SNF | |
| HP1-BP72 | |
| SNF2beta | |
| SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 | |
| brg-1 | |
| Possible global transcription activator SNF2L4 | |
| nuclear protein GRB I | |
| Smarca4 | |
| SNF2 (sucrose nonfermenting, yeast, homolog)-like 4 | |
| SNF2 (sucrose nonfermenting, yeast, homolog)-like IV | |
| SNF2B | |
| SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | |
| SNF2-like IV | |
| Brahma protein homolog 1 | |
| FLJ39786 | |
| sucrose nonfermenting-like IV | |
| Brahma protein homolog I | |
| brahma protein-like I | |
| Brahma-associated factor 190A | |
| brahma-related protein 1 | |
| chromatin remodeling factor Brg1 | |
| chromatin remodeling subunit BRG1 | |
| brahma-related protein I | |
| brm-associated factor 190A | |
| BRM/SWI2-related gene I | |
| BRG1/brm-associated factor 190A | |
| BRG1/Brahma-associated factor 190A | |
| SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4 | |
| Brahma protein homolog I | |
| Brahma protein homolog 1 | |
| BRG-1 protein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603254 |
|---|---|
| 614609 | |
| 613325 |
| Unigene ID | Hs.327527 |
|---|---|
| Mm.286593 | |
| Rn.23417 |
| KEGG ID | hsa:6597 |
|---|---|
| mmu:20586 | |
| rno:171379 |
| Swiss-Prot Accession | A7E2E1 |
|---|---|
| P51532 | |
| B3KNW7 | |
| Q9HBD4 | |
| Q3TKT4 | |
| Q8K1P7 | |
| B1A8Z4 | |
| B1A8Z5 | |
| B1A8Z6 | |
| B1A8Z7 | |
| E9PBR8 | |
| O95052 | |
| Q9HBD3 | |
| Q3TUD7 | |
| Q6AXG8 | |
| Q59FZ6 | |
| O35845 | |
| Q3UI73 | |
| Q3URH5 | |
| Q6P8K2 | |
| Q7TQL1 | |
| Q8BQ54 | |
| Q8CGJ5 | |
| Q8R0K1 | |
| Q8R569 | |
| Q63071 |
| EC Number | 3.6.4.- |
|---|---|
| 3.6.1.- |
| GO ID | 0005524 |
|---|---|
| 0003677 | |
| 0008094 | |
| 0030957 | |
| 0050681 | |
| 0004386 | |
| 0070577 | |
| 0002039 | |
| 0047485 | |
| 0003713 | |
| 0003714 | |
| 0006338 | |
| 0045749 | |
| 0060766 | |
| 0030308 | |
| 0000122 | |
| 0045892 | |
| 0007399 | |
| 0003407 | |
| 0006337 | |
| 0043923 | |
| 0051091 | |
| 0045944 | |
| 0045893 | |
| 0006357 | |
| 0006351 | |
| 0016514 | |
| 0071778 | |
| 0071565 | |
| 0071564 | |
| 0000790 | |
| 0005634 | |
| 0016887 | |
| 0000977 | |
| 0003682 | |
| 0016787 | |
| 0016817 | |
| 0016818 | |
| 0003676 | |
| 0000166 | |
| 0032403 | |
| 0008134 | |
| 0006200 | |
| 0043044 | |
| 0010424 | |
| 0035887 | |
| 0001832 | |
| 0001835 | |
| 0000902 | |
| 0016568 | |
| 0060318 | |
| 0035116 | |
| 0048562 | |
| 0048730 | |
| 0030198 | |
| 0030900 | |
| 0007403 | |
| 0007507 | |
| 0060347 | |
| 0030902 | |
| 0043966 | |
| 0001701 | |
| 0030216 | |
| 0001889 | |
| 0006346 | |
| 0006334 | |
| 0043388 | |
| 0006355 | |
| 0019827 | |
| 0001570 | |
| 0000792 | |
| 0005719 | |
| 0005730 | |
| 0005726 | |
| 0016563 | |
| 0010553 | |
| 0010552 | |
| 0045449 | |
| 0070603 | |
| 0006350 | |
| 0005625 | |
| 0042802 | |
| 0003700 | |
| 0005654 | |
| 0005515 | |
| 0008026 |
| PIR ID | S45252 |
|---|
| Swiss-Prot ID | SMCA4_HUMAN |
|---|---|
| SMCA4_MOUSE | |
| B1A8Z6_HUMAN | |
| B1A8Z5_HUMAN | |
| Q9HBD4_HUMAN | |
| A7E2E1_HUMAN | |
| B1A8Z7_HUMAN | |
| B3KNW7_HUMAN | |
| B1A8Z4_HUMAN | |
| Q6AXG8_MOUSE |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00293426 |
|---|---|
| IPI00900285 | |
| IPI00900328 | |
| IPI00900338 | |
| IPI01016040 | |
| IPI00875789 | |
| IPI00955124 | |
| IPI00029822 | |
| IPI00900269 | |
| IPI00460668 | |
| IPI00654251 | |
| IPI00781041 | |
| IPI00915110 | |
| IPI00781891 |
| Mouse chromosome position | 9 6.0 cM |
|---|
| Rat chromosome position | 8q13 |
|---|
| Homologene ID | 55712 |
|---|
| MGI ID | 88192 |
|---|
| RGD ID | 621728 |
|---|
| Primary Cell Localization | Nucleus |
|---|