Protein Btrc

URN	urn:agi-llid:8945
Total Entities	0
Connectivity	371
Name	Btrc
Description	beta-transducin repeat containing
Notes	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.

Ariadne Ontology	Secreted proteins

GO Molecular Function	beta-catenin binding
	protein phosphorylated amino acid binding
	ligase activity
	ubiquitin-protein ligase activity

GO Cellular Component	SCF ubiquitin ligase complex
	cytoplasm
	cytosol
	nucleus

GO Biological Process	viral reproduction
	virus-host interaction
	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
	mitotic cell cycle
	regulation of cell cycle
	negative regulation of smoothened signaling pathway
	regulation of I-kappaB kinase-NF-kappaB cascade
	signal transduction
	Wnt receptor signaling pathway
	regulation of proteasomal protein catabolic process
	positive regulation of transcription, DNA-dependent
	positive regulation of proteolysis
	negative regulation of transcription, DNA-dependent
	negative regulation of sequence-specific DNA binding transcription factor activity
	protein dephosphorylation
	protein ubiquitination
	protein polyubiquitination
	ubiquitin-dependent protein catabolic process
	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
	cellular response to organic cyclic compound
	mammary gland epithelial cell proliferation
	positive regulation of circadian rhythm
	protein destabilization
	branching involved in mammary gland duct morphogenesis
	protein catabolic process

Pathway	Cell Cycle
	Hedgehog signaling pathway
	Wnt signaling, canonical pathway
	altered Wnt signaling, canonical pathway
	canonical Wnt signaling pathway
	Wnt signaling, canonical pathway

Group	viral reproduction
	virus-host interaction
	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
	mitotic cell cycle
	regulation of cell cycle
	negative regulation of smoothened signaling pathway
	regulation of I-kappaB kinase-NF-kappaB cascade
	signal transduction
	Wnt receptor signaling pathway
	regulation of proteasomal protein catabolic process
	positive regulation of transcription, DNA-dependent
	positive regulation of proteolysis
	negative regulation of transcription, DNA-dependent
	negative regulation of sequence-specific DNA binding transcription factor activity
	protein dephosphorylation
	protein ubiquitination
	protein polyubiquitination
	ubiquitin-dependent protein catabolic process
	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
	cellular response to organic cyclic compound
	mammary gland epithelial cell proliferation
	positive regulation of circadian rhythm
	protein destabilization
	branching involved in mammary gland duct morphogenesis
	protein catabolic process
	beta-catenin binding
	protein phosphorylated amino acid binding
	ligase activity
	ubiquitin-protein ligase activity
	SCF ubiquitin ligase complex
	cytoplasm
	cytosol
	nucleus
	Secreted proteins

MedScan ID	8945

Hugo ID	1144

Human chromosome position	10q24.32

Alias	FWD1
	FBW1A
	FBXW1
	bTrCP
	FBXW1A
	bTrCP1
	betaTrCP
	BETA-TRCP
	RP11-529I10.2
	F-box/WD repeat-containing protein 1A
	beta-TrCP1
	E3RSIkappaB
	F-box and WD-repeat protein 1B
	epididymis tissue protein Li 2a
	pIkappaBalpha-E3 receptor subunit
	F-box and WD repeats protein beta-TrCP
	HOS
	Slimb
	b-TrCP
	mKIAA4123
	SCF b-TRCP
	mE3RS-IkappaB
	ubiquitin ligase FWD1
	pIkappaB-E3 receptor subunit
	beta-TrCP protein E3RS-IkappaB
	beta-transducin repeat-containing protein
	beta-transducin repeat containing protein
	Kiaa4123
	MGC105884
	MGC4643
	mSlimb
	OTTHUMP00000020314
	OTTHUMP00000020315
	FWD I
	pI kappa B alpha-E3 receptor subunit
	beta-transducin repeat containing
	BTRC
	E3RSI kappa B
	F-box and WD-repeats protein beta-TrCP
	Beta transducin repeats containing protein
	hypothetical protein MGC4643

OMIM ID	603482

Mouse chromosome position	19
	19 D1

Rat chromosome position	1q54

Homologene ID	39330

MGI ID	1338871

RGD ID	1359721