| URN | urn:agi-llid:8149 |
|---|---|
| Total Entities | 0 |
| Connectivity | 275 |
| Name | Sost |
| Description | sclerostin |
| Notes | Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq] |
| Ariadne Ontology | Secreted proteins |
|---|---|
| Biofluids assayable substances |
| GO Molecular Function | transcription factor binding |
|---|---|
| heparin binding |
| GO Cellular Component | extracellular matrix |
|---|---|
| extracellular region | |
| Golgi apparatus | |
| extracellular space |
| GO Biological Process | negative regulation of Wnt receptor signaling pathway |
|---|---|
| negative regulation of canonical Wnt receptor signaling pathway | |
| negative regulation of Wnt receptor signaling pathway involved in dorsal-ventral axis specification | |
| negative regulation of BMP signaling pathway | |
| Wnt receptor signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| cellular response to parathyroid hormone stimulus | |
| response to mechanical stimulus | |
| negative regulation of ossification | |
| negative regulation of protein complex assembly | |
| ossification |
| Pathway | Dexamethasone-Induced Neurotoxicity |
|---|---|
| Dexamethasone-Induced Diabetes | |
| Dexamethasone-Induced Osteoporosis | |
| BMP2-BMPR2 Expression Targets | |
| Wnt signaling, canonical pathway | |
| altered Wnt signaling, canonical pathway | |
| Wnt signaling, canonical pathway |
| Group | negative regulation of Wnt receptor signaling pathway |
|---|---|
| negative regulation of canonical Wnt receptor signaling pathway | |
| negative regulation of Wnt receptor signaling pathway involved in dorsal-ventral axis specification | |
| negative regulation of BMP signaling pathway | |
| Wnt receptor signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| cellular response to parathyroid hormone stimulus | |
| response to mechanical stimulus | |
| negative regulation of ossification | |
| negative regulation of protein complex assembly | |
| ossification | |
| transcription factor binding | |
| heparin binding | |
| extracellular matrix | |
| extracellular region | |
| Golgi apparatus | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 8149 |
|---|
| Hugo ID | 13771 |
|---|
| Human chromosome position | 17q11.2 |
|---|
| LocusLink ID | 8149 |
|---|---|
| 50964 | |
| 74499 | |
| 80722 |
| Alias | CDD |
|---|---|
| VBCH | |
| UNQ2976/PRO7455/PRO7476 | |
| sclerostin | |
| 5430411E23Rik | |
| RP23-398F7.2 | |
| sclerosteosis | |
| 5430411E23 | |
| van buchem disease gene | |
| SOST | |
| sclerosteosis protein | |
| sclerosteosis gene | |
| OTTMUSP00000002060 | |
| LOC629951 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605740 |
|---|---|
| 122860 | |
| 239100 | |
| 269500 |
| Unigene ID | Hs.349204 |
|---|---|
| Mm.265602 | |
| Rn.95369 |
| KEGG ID | hsa:50964 |
|---|---|
| mmu:74499 | |
| rno:80722 |
| Swiss-Prot Accession | Q9BQB4 |
|---|---|
| B1AQF2 | |
| Q99P68 | |
| Q99P67 | |
| Q495N9 | |
| Q9D3L7 | |
| Q7Z2R3 | |
| Q7Z4G0 |
| GO ID | 0008201 |
|---|---|
| 0008134 | |
| 0016055 | |
| 0071374 | |
| 0030514 | |
| 2000054 | |
| 0090090 | |
| 0030279 | |
| 0031333 | |
| 0001503 | |
| 0045893 | |
| 0009612 | |
| 0031012 | |
| 0005615 | |
| 0030178 | |
| 0005794 | |
| 0005576 |
| Swiss-Prot ID | SOST_HUMAN |
|---|---|
| SOST_MOUSE | |
| SOST_RAT | |
| B1AQF2_MOUSE | |
| B2RQA5_MOUSE |
| Cell Localization | Secreted |
|---|
| IPI ID | IPI00019272 |
|---|---|
| IPI00410101 | |
| IPI00321910 | |
| IPI00200398 | |
| IPI00896590 | |
| IPI00384900 | |
| IPI00385104 |
| Mouse chromosome position | 11 |
|---|
| Rat chromosome position | 10q32.1 |
|---|
| Homologene ID | 11542 |
|---|
| MGI ID | 1921749 |
|---|
| RGD ID | 69358 |
|---|