Protein Ctnnb1

URN urn:agi-llid:1499
Total Entities 0
Connectivity 3753
Name Ctnnb1
Description catenin (cadherin associated protein), beta 1
Notes involved in mediating the interaction between cadherins and the actin cytoskeleton [RGD]

Ariadne Ontology Adherens junction assembly
CTNNB1
Secreted proteins
Biofluids assayable substances

GO Molecular Function structural molecule activity
chromatin binding
protein complex binding
SMAD binding
ion channel binding
protein C-terminus binding
transcription factor binding
alpha-catenin binding
enzyme binding
repressing transcription factor binding
nuclear hormone receptor binding
estrogen receptor binding
androgen receptor binding
ionotropic glutamate receptor binding
kinase binding
protein kinase binding
protein phosphatase binding
cadherin binding
I-SMAD binding
R-SMAD binding
DNA binding
double-stranded DNA binding
transcription regulatory region DNA binding
transcription coactivator activity
sequence-specific DNA binding transcription factor activity
signal transducer activity

GO Cellular Component cell junction
membrane
synapse
Z disc
transcription factor complex
beta-catenin-TCF7L2 complex
spindle pole
centrosome
cell projection membrane
lateral plasma membrane
basolateral plasma membrane
internal side of plasma membrane
catenin complex
microvillus membrane
protein complex
protein-DNA complex
Scrib-APC-beta-catenin complex
beta-catenin destruction complex
apical part of cell
plasma membrane
cell periphery
cytoplasm
perinuclear region of cytoplasm
cytosol
cell cortex
cytoskeleton
nucleus
dendritic shaft
neuron projection
lamellipodium
cell-cell junction
apical junction complex
cell-cell adherens junction
desmosome
zonula adherens
fascia adherens
intercalated disc
adherens junction
cell-substrate adherens junction

GO Biological Process cell proliferation
cellular process
cell adhesion
regulation of centriole-centriole cohesion
regulation of centromeric sister chromatid cohesion
epithelial cell differentiation involved in prostate gland development
oocyte development
positive regulation of epithelial cell proliferation involved in prostate gland development
synaptic transmission
lung induction
negative regulation of heart induction by canonical Wnt receptor signaling pathway
positive regulation of fibroblast growth factor receptor signaling pathway
positive regulation of I-kappaB kinase-NF-kappaB cascade
positive regulation of MAPK cascade
regulation of myelination
regulation of cell differentiation
regulation of cell proliferation
androgen receptor signaling pathway
Wnt receptor signaling pathway
canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
canonical Wnt receptor signaling pathway
canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition
canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process
positive regulation of transcription, DNA-dependent
positive regulation of transcription from RNA polymerase II promoter
positive regulation of heparan sulfate proteoglycan biosynthetic process
negative regulation of transcription, DNA-dependent
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-dependent
regulation of transcription from RNA polymerase II promoter
negative regulation of cell differentiation
negative regulation of cell proliferation
negative regulation of chondrocyte differentiation
negative regulation of osteoclast differentiation
negative regulation of oligodendrocyte differentiation
negative regulation of apoptotic process
positive regulation of cell proliferation
positive regulation of mesenchymal cell proliferation
positive regulation of neuroblast proliferation
positive regulation of muscle cell differentiation
positive regulation of osteoblast differentiation
positive regulation of epithelial cell differentiation
positive regulation of epithelial to mesenchymal transition
positive regulation of endothelial cell differentiation
positive regulation of apoptotic process
regulation of T cell proliferation
regulation of protein localization to cell surface
regulation of fibroblast proliferation
regulation of smooth muscle cell proliferation
regulation of secondary heart field cardioblast proliferation
regulation of osteoblast differentiation
regulation of epithelial cell differentiation
regulation of osteoclast differentiation
regulation of nephron tubule epithelial cell differentiation
regulation of apoptotic process
regulation of calcium ion import
cell differentiation
cell maturation
cell fate specification
cell fate determination
cell morphogenesis involved in differentiation
epithelial to mesenchymal transition
mesenchymal to epithelial transition involved in metanephros morphogenesis
muscle cell differentiation
vasculogenesis
lung cell differentiation
central nervous system vasculogenesis
hair cell differentiation
T cell differentiation
T cell differentiation in thymus
osteoclast differentiation
cardiac vascular smooth muscle cell differentiation
epicardium-derived cardiac vascular smooth muscle cell differentiation
smooth muscle cell differentiation
myoblast differentiation
glial cell fate determination
endodermal cell fate commitment
transcription, DNA-dependent
cell-cell adhesion
cell-matrix adhesion
cytoskeletal anchoring at plasma membrane
neuron migration
cellular response to indole-3-methanol
cellular response to organic cyclic compound
cellular response to growth factor stimulus
apoptotic process
cellular protein localization
protein localization to cell surface
adherens junction assembly
cellular component disassembly involved in execution phase of apoptosis
mesenchymal cell proliferation involved in lung development
Schwann cell proliferation
cardiac muscle cell proliferation
response to drug
response to cadmium ion
response to cytokine stimulus
response to organic cyclic compound
response to hormone stimulus
response to estrogen stimulus
response to estradiol stimulus
positive regulation of branching involved in lung morphogenesis
regulation of angiogenesis
positive regulation of determination of dorsal identity
positive regulation of gene expression
regulation of gene expression
genitalia morphogenesis
oviduct development
male genitalia development
embryonic digit morphogenesis
embryonic foregut morphogenesis
lens morphogenesis in camera-type eye
renal vesicle formation
hair follicle morphogenesis
mesenchyme morphogenesis
fungiform papilla formation
patterning of blood vessels
branching involved in ureteric bud morphogenesis
epithelial tube branching involved in lung morphogenesis
endoderm formation
hair follicle placode formation
trachea formation
embryonic skeletal limb joint morphogenesis
nephron tubule formation
ventricular compact myocardium morphogenesis
forebrain development
renal inner medulla development
renal outer medulla development
hindbrain development
organ development
skeletal system development
renal system development
embryonic heart tube development
pancreas development
liver development
lung development
kidney development
heart development
hemopoiesis
thymus development
ectoderm development
mesenchyme development
neural plate development
skin development
lung-associated mesenchyme development
midgut development
in utero embryonic development
limb development
embryonic axis specification
dorsal-ventral axis specification
anterior-posterior axis specification
dorsal-ventral pattern formation
proximal-distal pattern formation
determination of dorsal-ventral asymmetry
morphogenesis of embryonic epithelium
gastrulation with mouth forming second
embryonic limb morphogenesis
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
endothelial tube morphogenesis
trachea morphogenesis
tongue morphogenesis
metanephros morphogenesis
odontogenesis of dentin-containing tooth
coronary artery morphogenesis
hair cycle process
synaptic vesicle transport
synapse organization
protein heterooligomerization
bone resorption

Pathway Desmosome Assembly
Gap Junction Assembly
Tight Junction Assembly (Occludin)
Adherens Junction Assembly (Cadherins)
FrizzledR -> CTNNB signaling
PTPRF -> CTNNB signaling
PTPRU -> CTNNB signaling
EGFR/ERBB2 -> CTNNB signaling
VEGFR -> CTNNB signaling
InsulinR -> CTNNB/FOXA/FOXO signaling
FibronectinR -> CTNNB signaling
ICAM2 -> CTNNB/FOXO/STAT3 signaling
PECAM -> CTNNB1 signaling
Sialophorin -> CTNNB/MYC/TP53 signaling
Dexamethasone-Induced Osteoporosis
Canonical WNT Signaling Expression Targets
WNT7A Expression Targets
WNT1 Expression Targets
WNT4 Expression Targets
WNT3A Expression Targets
WNT2 Expression Targets
WNT7B Expression Targets
Fibronectin Expression Targets
EREG/CTNNB/CTNND Expression Target
NRG1/Catenin Expression Targets
TGFA/CTNNB/CTNND Expression Targets
VEGFA/CTNNB/CTNND Expression Targets
VEGFC/CTNNB Expression Target
WNT5A Expression Targets
IL1B/NO Expression Targets
Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets
WNT9B Expression Targets
WNT9A Expression Targets
AREG/CTNN Expression Targets
BTC/CTNN Expression Targets
EGF/CTNN Expression Targets
Wnt signaling, canonical pathway
endometrial cancer pathway
endometrial cancer pathway
canonical Wnt signaling pathway
colorectal cancer pathway
colorectal cancer pathway
Wnt signaling, canonical pathway

Group Adherens junction assembly
CTNNB1
cell proliferation
cellular process
cell adhesion
regulation of centriole-centriole cohesion
regulation of centromeric sister chromatid cohesion
epithelial cell differentiation involved in prostate gland development
oocyte development
positive regulation of epithelial cell proliferation involved in prostate gland development
synaptic transmission
lung induction
negative regulation of heart induction by canonical Wnt receptor signaling pathway
positive regulation of fibroblast growth factor receptor signaling pathway
positive regulation of I-kappaB kinase-NF-kappaB cascade
positive regulation of MAPK cascade
regulation of myelination
regulation of cell differentiation
regulation of cell proliferation
androgen receptor signaling pathway
Wnt receptor signaling pathway
canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
canonical Wnt receptor signaling pathway
canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition
canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process
positive regulation of transcription, DNA-dependent
positive regulation of transcription from RNA polymerase II promoter
positive regulation of heparan sulfate proteoglycan biosynthetic process
negative regulation of transcription, DNA-dependent
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-dependent
regulation of transcription from RNA polymerase II promoter
negative regulation of cell differentiation
negative regulation of cell proliferation
negative regulation of chondrocyte differentiation
negative regulation of osteoclast differentiation
negative regulation of oligodendrocyte differentiation
negative regulation of apoptotic process
positive regulation of cell proliferation
positive regulation of mesenchymal cell proliferation
positive regulation of neuroblast proliferation
positive regulation of muscle cell differentiation
positive regulation of osteoblast differentiation
positive regulation of epithelial cell differentiation
positive regulation of epithelial to mesenchymal transition
positive regulation of endothelial cell differentiation
positive regulation of apoptotic process
regulation of T cell proliferation
regulation of protein localization to cell surface
regulation of fibroblast proliferation
regulation of smooth muscle cell proliferation
regulation of secondary heart field cardioblast proliferation
regulation of osteoblast differentiation
regulation of epithelial cell differentiation
regulation of osteoclast differentiation
regulation of nephron tubule epithelial cell differentiation
regulation of apoptotic process
regulation of calcium ion import
cell differentiation
cell maturation
cell fate specification
cell fate determination
cell morphogenesis involved in differentiation
epithelial to mesenchymal transition
mesenchymal to epithelial transition involved in metanephros morphogenesis
muscle cell differentiation
vasculogenesis
lung cell differentiation
central nervous system vasculogenesis
hair cell differentiation
T cell differentiation
T cell differentiation in thymus
osteoclast differentiation
cardiac vascular smooth muscle cell differentiation
epicardium-derived cardiac vascular smooth muscle cell differentiation
smooth muscle cell differentiation
myoblast differentiation
glial cell fate determination
endodermal cell fate commitment
transcription, DNA-dependent
cell-cell adhesion
cell-matrix adhesion
cytoskeletal anchoring at plasma membrane
neuron migration
cellular response to indole-3-methanol
cellular response to organic cyclic compound
cellular response to growth factor stimulus
apoptotic process
cellular protein localization
protein localization to cell surface
adherens junction assembly
cellular component disassembly involved in execution phase of apoptosis
mesenchymal cell proliferation involved in lung development
Schwann cell proliferation
cardiac muscle cell proliferation
response to drug
response to cadmium ion
response to cytokine stimulus
response to organic cyclic compound
response to hormone stimulus
response to estrogen stimulus
response to estradiol stimulus
positive regulation of branching involved in lung morphogenesis
regulation of angiogenesis
positive regulation of determination of dorsal identity
positive regulation of gene expression
regulation of gene expression
genitalia morphogenesis
oviduct development
male genitalia development
embryonic digit morphogenesis
embryonic foregut morphogenesis
lens morphogenesis in camera-type eye
renal vesicle formation
hair follicle morphogenesis
mesenchyme morphogenesis
fungiform papilla formation
patterning of blood vessels
branching involved in ureteric bud morphogenesis
epithelial tube branching involved in lung morphogenesis
endoderm formation
hair follicle placode formation
trachea formation
embryonic skeletal limb joint morphogenesis
nephron tubule formation
ventricular compact myocardium morphogenesis
forebrain development
renal inner medulla development
renal outer medulla development
hindbrain development
organ development
skeletal system development
renal system development
embryonic heart tube development
pancreas development
liver development
lung development
kidney development
heart development
hemopoiesis
thymus development
ectoderm development
mesenchyme development
neural plate development
skin development
lung-associated mesenchyme development
midgut development
in utero embryonic development
limb development
embryonic axis specification
dorsal-ventral axis specification
anterior-posterior axis specification
dorsal-ventral pattern formation
proximal-distal pattern formation
determination of dorsal-ventral asymmetry
morphogenesis of embryonic epithelium
gastrulation with mouth forming second
embryonic limb morphogenesis
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
endothelial tube morphogenesis
trachea morphogenesis
tongue morphogenesis
metanephros morphogenesis
odontogenesis of dentin-containing tooth
coronary artery morphogenesis
hair cycle process
synaptic vesicle transport
synapse organization
protein heterooligomerization
bone resorption
structural molecule activity
chromatin binding
protein complex binding
SMAD binding
ion channel binding
protein C-terminus binding
transcription factor binding
alpha-catenin binding
enzyme binding
repressing transcription factor binding
nuclear hormone receptor binding
estrogen receptor binding
androgen receptor binding
ionotropic glutamate receptor binding
kinase binding
protein kinase binding
protein phosphatase binding
cadherin binding
I-SMAD binding
R-SMAD binding
DNA binding
double-stranded DNA binding
transcription regulatory region DNA binding
transcription coactivator activity
sequence-specific DNA binding transcription factor activity
signal transducer activity
cell junction
membrane
synapse
Z disc
transcription factor complex
beta-catenin-TCF7L2 complex
spindle pole
centrosome
cell projection membrane
lateral plasma membrane
basolateral plasma membrane
internal side of plasma membrane
catenin complex
microvillus membrane
protein complex
protein-DNA complex
Scrib-APC-beta-catenin complex
beta-catenin destruction complex
apical part of cell
plasma membrane
cell periphery
cytoplasm
perinuclear region of cytoplasm
cytosol
cell cortex
cytoskeleton
nucleus
dendritic shaft
neuron projection
lamellipodium
cell-cell junction
apical junction complex
cell-cell adherens junction
desmosome
zonula adherens
fascia adherens
intercalated disc
adherens junction
cell-substrate adherens junction
Secreted proteins
Biofluids assayable substances

Source Curated

MedScan ID 1499

Hugo ID 2514

Human chromosome position 3p21

GenBank ID NC_000003
NM_001904
NP_001895
NM_001098209
NP_001091679
NM_001098210
NP_001091680
NG_013302
NC_018914
AC_000135
AC104307
AY081165
AAL89457
AY463360
AAR18817
CH471055
EAW64625
EAW64626
EAW64627
EAW64628
JA780904
CCH22596
JN314422
AEW16366
AB062292
BAB93475
AB451264
BAG70078
AB451392
BAG70206
AK095242
AK289932
BAF82621
AK294778
BAG57905
AK296790
BAG59368
AK299954
BAG61781
AK314776
BC058926
AAH58926
BX648430
DA216720
X87838
CAA61107
Z19054
CAA79497
P35222
EU446854
ABZ92383
NC_000075
NM_007614
NP_031640
NM_001165902
NP_001159374
AC_000031
AC145731
CH466587
EDL09164
EDL09165
EDL09166
AK018515
BAB31250
AK020013
AK035311
BAC29027
AK132398
AK133656
BAE21768
AK135743
AK178155
AK179148
AK179260
AK180997
AK184861
AK189807
AK190684
AK191852
AK196236
AK196547
AK197513
AK197664
AK197753
AK199952
AK201646
AK201809
AK202371
AK203436
AK203824
AK204053
AK208830
AK209047
AK209437
AK209908
AK210588
AK211747
AK214825
AK219273
AK219949
AY751549
BC006739
AAH06739
BC043078
BC043481
AAH43481
BC048153
AAH48153
BC053065
AAH53065
BY766878
M90364
AAA37280
Q02248
NC_005107
NM_053357
NP_445809
AC_000076
AF397179
AAK85253
AF486617
CH473954
EDL76848
EDL76849
EDL76850
EDL76851
AF121265
AAD28504
FJ002272
ACI16374
FJ002273
ACI16375
FJ002274
ACI16376
FQ222424
FQ224468
Q9WU82
NT_022517
NW_001838877
NW_921651
AC_000046
CR596976
CR604301
NT_039482
NW_001030922
Q3UZT7
Q80VE7
NW_001084876
NW_047803
XP_950741
XP_950748
XM_945648
XP_950746
XP_950747
XP_950744
XP_950745
XP_950743
XM_942045
AF130085
XM_945650
XP_950750
XM_945652
XM_945651
XM_945654
XM_945653
XM_945655
XM_945657
BG065470
NW_000361
BI134907
AW107308
XP_947138
BG078748
AAG35511

LocusLink ID 1499
12387
84353
360543
252926
209012

Alias CTNNB
OK/SW-cl.35
catenin beta-1
Bfc
Mesc
Catnb
beta-catenin
catenin beta
catenin (cadherin associated protein), beta 1, 88kDa
OTTHUMP00000209289
FLJ37923
CTNB
CTNB_HUMAN
CTNNB I
DKFZp686D02253
FLJ25606
LOC316084
OTTHUMP00000165223
CTNNB1
OTTMUSP00000017750
OTTHUMP00000165222
beta catenin
eta-catenin
88 kDa catenin (cadherin-associated protein), beta 1
88 kDa catenin (cadherin-associated protein), beta I
beta 1 catenin
Beta-cat
cadherin-associated protein beta 1
cadherin-associated protein-beta-catenin
catenin (cadherin associated protein), beta 1
catenin (cadherin associated protein), beta I
cadherin-associated protein-beta-catenin 1
b-catenin
catenin beta I
catenin (cadherin-associated protein), beta 1, 88kDa
catenin (cadherin-associated protein), beta 1 (88kD)
cadherin associated protein
catenin (cadherin-associated protein), beta 1
Ctnnb1s
catenin (cadherin-associated protein), beta I
catenin beta 1
Postsynaptic density protein PSD-93
catenin (cadherin-associated protein), beta 1 (88kDa
Ctnnb Is

Organism Homo sapiens
Mus musculus
Rattus norvegicus

OMIM ID 116806
114550
167000
132600
155255

Unigene ID Hs.476018
Mm.291928
Rn.112601
Mm.387252
Mm.358836
Mm.371804

KEGG ID hsa:1499
mmu:12387
rno:84353

Swiss-Prot Accession P35222
Q02248
Q9WU82
Q922W1
Q9D335
A8K1L7
Q8NEW9
Q8NI94
Q9H391
Q3UZT7
Q80VE7

GO ID 0070411
0070412
0046332
0045294
0050681
0045296
0003682
0003690
0019899
0030331
0044325
0035255
0019900
0035257
0008022
0019901
0019903
0070491
0003700
0004871
0005198
0003713
0008134
0044212
0014010
0033077
0016055
0034333
0030521
0009948
0006915
0045453
0001658
0060070
0044336
0061324
0044334
0007155
0001708
0048469
0016337
0007160
0006921
0071363
0071681
0071407
0022009
0007016
0048262
0009950
0007398
0000578
0042733
0048617
0035050
0035116
0030326
0036023
0001711
0061154
0060742
0001837
0060441
0030900
0061198
0001702
0035112
0007403
0035315
0031069
0060789
0030902
0001701
0002089
0001889
0060479
0060492
0060484
0030539
0060916
0003337
0007494
0042692
0045445
0008285
0032331
0003136
0048715
0045671
0000122
0045892
0072079
0001764
0042475
0048599
0030316
0060066
0031016
0001569
0043123
0043410
0043065
0061047
2000017
0045603
0060769
0045743
0010909
0002053
0051149
0002052
0045669
0045944
0045893
0034394
0009954
0042129
0045765
0090279
0030997
0070602
0048145
0031641
0072182
2000008
0003266
0048660
0072053
0072054
0072033
0046686
0034097
0042493
0032355
0043588
0051145
0050808
0048489
0048538
0043587
0060440
0006351
0034750
0030018
0005912
0045177
0016323
0070369
0016342
0005938
0030054
0071944
0005913
0005911
0005924
0005813
0005737
0005829
0043198
0030057
0005916
0009898
0030027
0016328
0016020
0031528
0005634
0048471
0005886
0032993
0000922
0045202
0005667
0005915
0003677
0032403
0030217
0060038
0060947
0030154
0001709
0000904
0008283
0009987
0034613
0060982
0009953
0035115
0001706
0060983
0022405
0007507
0030097
0001822
0060173
0030324
0060485
0072132
0003338
0016331
0043066
0045596
0001840
0048513
0008284
0030858
0010718
0010628
0051291
0042981
0045595
0042127
0030856
0010468
0045667
0045670
0006357
0006355
0072001
0043627
0001501
0007268
0060439
0001570
0003223
0043296
0030877
0031253
0005856
0014704
0043005
0043234
0009725
0014070
0034742
0034747
0045768
0010843
0048593
0035117
0010552
0045941
0005624
0016563
0010551
0045449
0006350
0051091
0042301
0005488
0005515
0016301
0005524
0016740
0008013
0050875
0010003
0048595
0000166

PIR ID S35091
A38973

Swiss-Prot ID CTNB1_RAT
CTNB1_MOUSE
CTNB1_HUMAN
A8K1L7_HUMAN

Cell Localization Cytoplasm
cytoskeleton
Nucleus
Cell junction
adherens junction
Cell membrane
centrosome
spindle pole
Plasma membrane

IPI ID IPI00325912
IPI00125899
IPI00017292
IPI00927799
IPI00792321
IPI00219893
IPI00903028
IPI00788993
IPI00753025
IPI00754516
IPI00753627

Mouse chromosome position 9 72.0 cM

Rat chromosome position 8q32

Homologene ID 1434

MGI ID 88276
1921622

RGD ID 70487
620703

Primary Cell Localization Plasma membrane
Cytoplasm

LocatorString pmquery:regulation+of+canonical+Wnt+pathway