| URN | urn:agi-llid:25928 |
|---|---|
| Connectivity | 47 |
| Name | Sostdc1 |
| Description | sclerostin domain containing 1 |
| Notes | This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq] |
| Pathway | Wnt signaling, canonical pathway |
|---|---|
| altered Wnt signaling, canonical pathway |
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space |
| GO Biological Process | pattern specification process |
|---|---|
| embryo implantation | |
| odontogenesis of dentine-containing tooth | |
| negative regulation of BMP signaling pathway | |
| Wnt receptor signaling pathway |
| Group | extracellular region |
|---|---|
| pattern specification process | |
| embryo implantation | |
| odontogenesis of dentine-containing tooth | |
| negative regulation of BMP signaling pathway | |
| Wnt receptor signaling pathway | |
| extracellular space |
| MedScan ID | 25928 |
|---|
| Hugo ID | 21748 |
|---|
| Human chromosome position | 7p21.1 |
|---|
| LocusLink ID | 25928 |
|---|---|
| 66042 | |
| 266803 |
| Alias | USAG1 |
|---|---|
| CDA019 | |
| ECTODIN | |
| DKFZp564D206 | |
| sclerostin domain-containing protein 1 | |
| ectodermal BMP inhibitor | |
| cystine-knot containing secreted protein | |
| uterine sensitization-associated protein-1 | |
| Wise | |
| Sostl | |
| USAG-1 | |
| 0610006G05Rik | |
| sclerostin-like protein | |
| uterine sensitization-associated protein 1 | |
| uterine sensitization-associated gene 1 protein | |
| wnt-signaling modulator | |
| 0610006G05 | |
| ECTODINs | |
| sclerostin domain containing 1 | |
| sclerostin domain containing I | |
| sclerostin-like | |
| SOSTDC1 | |
| Usag I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 609675 |
|---|
| Mouse chromosome position | 12 |
|---|
| GO ID | 0016055 |
|---|---|
| 0005576 | |
| 0030514 | |
| 0042475 | |
| 0007389 | |
| 0005615 | |
| 0007566 |
| Rat chromosome position | 6q16 |
|---|
| Swiss-Prot Accession | A4D125 |
|---|---|
| Q6X4U4 | |
| Q9CQN4 | |
| Q642G2 | |
| Q96HJ7 | |
| Q9Y3U3 | |
| Q8CJA4 | |
| Q8CF09 |
| PIR ID | T08710 |
|---|
| Unigene ID | Hs.648106 |
|---|---|
| Mm.43375 | |
| Rn.2415 |
| KEGG ID | hsa:25928 |
|---|---|
| mmu:66042 | |
| rno:266803 |
| Swiss-Prot ID | SOSD1_HUMAN |
|---|---|
| SOSD1_RAT | |
| SOSD1_MOUSE | |
| A4D125_HUMAN |
| Cell Localization | Secreted |
|---|
| IPI ID | IPI00479196 |
|---|---|
| IPI00194602 | |
| IPI00132766 | |
| IPI00640854 |
| Homologene ID | 9154 |
|---|
| RGD ID | 628877 |
|---|
| MGI ID | 1913292 |
|---|