Protein Smarca4

URN	urn:agi-llid:6597
Connectivity	328
Name	Smarca4
Description	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Notes	The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Alternatively spliced transcripts have been found for this gene, but their full-length natures have not been determined.

Pathway	canonical Wnt signaling pathway
	altered canonical Wnt signaling pathway
	canonical Wnt signaling pathway
	altered canonical Wnt signaling pathway
	Wnt signaling, canonical pathway
	altered Wnt signaling, canonical pathway

GO Molecular Function	nucleotide binding
	chromatin binding
	nucleic acid binding
	hydrolase activity
	transcription activator activity
	protein N-terminus binding
	transcription factor binding
	p53 binding
	DNA binding
	histone acetyl-lysine binding
	ATP binding
	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
	helicase activity
	ATPase activity
	DNA-dependent ATPase activity

GO Biological Process	forebrain development
	hindbrain development
	blastocyst growth
	heart trabecula formation
	nervous system development
	heart development
	vasculogenesis
	glial cell fate determination
	keratinocyte differentiation
	epidermis morphogenesis
	embryonic hindlimb morphogenesis
	blastocyst hatching
	extracellular matrix organization
	negative regulation of S phase of mitotic cell cycle
	regulation of transcription
	negative regulation of transcription from RNA polymerase II promoter
	methylation-dependent chromatin silencing
	negative regulation of gene-specific transcription from RNA polymerase II promoter
	positive regulation of transcription from RNA polymerase II promoter
	positive regulation of gene-specific transcription from RNA polymerase II promoter
	positive regulation of transcription factor activity
	transcription
	chromatin modification
	nucleosome assembly
	nucleosome disassembly
	chromatin remodeling
	ATP-dependent chromatin remodeling

Ariadne Ontology	Chromatin remodeling

Group	Chromatin remodeling
	forebrain development
	hindbrain development
	blastocyst growth
	heart trabecula formation
	nervous system development
	heart development
	vasculogenesis
	glial cell fate determination
	keratinocyte differentiation
	epidermis morphogenesis
	embryonic hindlimb morphogenesis
	blastocyst hatching
	extracellular matrix organization
	negative regulation of S phase of mitotic cell cycle
	regulation of transcription
	negative regulation of transcription from RNA polymerase II promoter
	methylation-dependent chromatin silencing
	negative regulation of gene-specific transcription from RNA polymerase II promoter
	positive regulation of transcription from RNA polymerase II promoter
	positive regulation of gene-specific transcription from RNA polymerase II promoter
	positive regulation of transcription factor activity
	transcription
	chromatin modification
	nucleosome assembly
	nucleosome disassembly
	chromatin remodeling
	ATP-dependent chromatin remodeling
	nucleotide binding
	chromatin binding
	nucleic acid binding
	hydrolase activity
	transcription activator activity
	protein N-terminus binding
	transcription factor binding
	p53 binding
	DNA binding
	histone acetyl-lysine binding
	ATP binding
	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
	helicase activity
	ATPase activity
	DNA-dependent ATPase activity
	soluble fraction
	nucleolus
	SWI-SNF-type complex
	perichromatin fibrils
	npBAF complex
	nBAF complex
	SWI-SNF complex
	nuclear euchromatin
	heterochromatin
	nucleus

MedScan ID	6597

Hugo ID	11100

Human chromosome position	19p13.2

Alias	BRG1
	SNF2
	SWI2
	RTPS2
	BAF190
	SNF2L4
	SNF2LB
	hSNF2b
	FLJ39786
	SNF2-BETA
	transcription activator BRG1
	BAF190A
	SNF2-like 4
	protein BRG-1
	nuclear protein GRB1
	brahma protein-like 1
	BRM/SWI2-related gene 1
	homeotic gene regulator
	protein brahma homolog 1
	BRG1-associated factor 190A
	sucrose nonfermenting-like 4
	ATP-dependent helicase SMARCA4
	mitotic growth and transcription activator
	global transcription activator homologous sequence
	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
	SW1/SNF
	HP1-BP72
	SNF2beta
	brg-1
	Brahma protein homolog 1
	Brahma protein homolog I
	brahma protein-like I
	brahma-related protein 1
	brahma-related protein I
	BRM/SWI2-related gene I
	chromatin remodeling factor Brg1
	chromatin remodeling subunit BRG1
	nuclear protein GRB I
	Possible global transcription activator SNF2L4
	Smarca4
	SNF2 (sucrose nonfermenting, yeast, homolog)-like 4
	SNF2 (sucrose nonfermenting, yeast, homolog)-like IV
	SNF2B
	SNF2-like IV
	sucrose nonfermenting-like IV
	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
	BRG1/brm-associated factor 190A
	brm-associated factor 190A
	Brahma-associated factor 190A
	BRG1/Brahma-associated factor 190A
	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4
	Brahma protein homolog I
	Brahma protein homolog 1
	BRG-1 protein

OMIM ID	603254
	613325

Mouse chromosome position	9 6.0 cM

Rat chromosome position	8q13

PIR ID	S45252

EC Number	3.6.1.-

Cell Localization	Nucleus

Homologene ID	55712

RGD ID	621728

MGI ID	88192