| URN | urn:agi-llid:4040 |
|---|---|
| Connectivity | 128 |
| Name | Lrp6 |
| Description | low density lipoprotein receptor-related protein 6 |
| Notes | LRP6 may function as a potential oncogenic protein by modulating Wnt/beta-catenin signaling LRP6 may function as a potential oncogenic protein by modulating Wnt/beta-catenin signaling. SOST antagonizes Wnt signaling by binding to the extracellular domain of the Wnt coreceptors LRP5 and LRP6 and disrupting Wnt-induced Frizzled-LRP complex formation. Wnt canonical signaling through LRP6 establishes a novel mechanism for receptor activation which is opposite to the general paradigm of ligand-induced receptor oligomerization. Role for an LDL receptor-related protein in the regulation of vascular smooth muscle cell proliferation and survival through the evolutionary conserved Wnt signaling cascade. |
| Pathway | FrizzledR -> CTNNB signaling |
|---|---|
| canonical Wnt signaling pathway | |
| altered canonical Wnt signaling pathway | |
| canonical Wnt signaling pathway | |
| altered canonical Wnt signaling pathway | |
| Wnt signaling, canonical pathway | |
| altered Wnt signaling, canonical pathway |
| GO Molecular Function | low-density lipoprotein receptor activity |
|---|---|
| receptor activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| endoplasmic reticulum | |
| membrane fraction | |
| integral to membrane |
| GO Biological Process | multicellular organismal development |
|---|---|
| neural tube development | |
| midbrain-hindbrain boundary development | |
| retina morphogenesis in camera-type eye | |
| tail morphogenesis | |
| somitogenesis | |
| primitive streak formation | |
| neural tube closure | |
| axis elongation | |
| anterior-posterior pattern formation | |
| dorsal-ventral axis specification | |
| pericardium morphogenesis | |
| embryonic digit morphogenesis | |
| heart looping | |
| gastrulation with mouth forming second | |
| embryonic forelimb morphogenesis | |
| embryonic hindlimb morphogenesis | |
| embryonic camera-type eye morphogenesis | |
| convergent extension | |
| endocytosis | |
| negative regulation of Wnt receptor signaling pathway | |
| cell migration involved in gastrulation | |
| response to peptide hormone stimulus | |
| Wnt receptor signaling pathway | |
| Wnt receptor signaling pathway through beta-catenin |
| Ariadne Ontology | FZD |
|---|
| Group | FZD |
|---|---|
| multicellular organismal development | |
| neural tube development | |
| midbrain-hindbrain boundary development | |
| retina morphogenesis in camera-type eye | |
| tail morphogenesis | |
| somitogenesis | |
| primitive streak formation | |
| neural tube closure | |
| axis elongation | |
| anterior-posterior pattern formation | |
| dorsal-ventral axis specification | |
| pericardium morphogenesis | |
| embryonic digit morphogenesis | |
| heart looping | |
| gastrulation with mouth forming second | |
| embryonic forelimb morphogenesis | |
| embryonic hindlimb morphogenesis | |
| embryonic camera-type eye morphogenesis | |
| convergent extension | |
| endocytosis | |
| negative regulation of Wnt receptor signaling pathway | |
| cell migration involved in gastrulation | |
| response to peptide hormone stimulus | |
| Wnt receptor signaling pathway | |
| Wnt receptor signaling pathway through beta-catenin | |
| low-density lipoprotein receptor activity | |
| receptor activity | |
| membrane | |
| plasma membrane | |
| endoplasmic reticulum | |
| membrane fraction | |
| integral to membrane |
| MedScan ID | 4040 |
|---|
| Hugo ID | 6698 |
|---|
| Human chromosome position | 12p13.3-p11.2 |
|---|---|
| 12p11-p13 |
| LocusLink ID | 4040 |
|---|---|
| 16974 | |
| 312781 |
| Alias | ADCAD2 |
|---|---|
| FLJ90062 | |
| FLJ90421 | |
| low-density lipoprotein receptor-related protein 6 | |
| LRP-6 | |
| Cd | |
| C030016K15Rik | |
| crooked | |
| OTTMUSP00000023469 | |
| low density lipoprotein-related protein 6 | |
| low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6 | |
| C030016K15 | |
| LDL receptor-related protein 6 | |
| LDL receptor-related protein VI | |
| LOC232429 | |
| LOC269807 | |
| low density lipoprotein receptor-related protein 6 | |
| low density lipoprotein receptor-related protein VI | |
| low density lipoprotein-related protein VI | |
| Lrp6 | |
| low density lipoprotein receptor-related protein 6 (predicted) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603507 |
|---|---|
| 610947 |
| Mouse chromosome position | 6 63.8 cM |
|---|
| GO ID | 0005041 |
|---|---|
| 0004872 | |
| 0016055 | |
| 0060070 | |
| 0009952 | |
| 0042074 | |
| 0009950 | |
| 0048596 | |
| 0042733 | |
| 0035115 | |
| 0035116 | |
| 0006897 | |
| 0001702 | |
| 0007275 | |
| 0030178 | |
| 0060042 | |
| 0005783 | |
| 0016021 | |
| 0005624 | |
| 0005886 | |
| 0003401 | |
| 0060026 | |
| 0001947 | |
| 0030917 | |
| 0001843 | |
| 0021915 | |
| 0003344 | |
| 0090009 | |
| 0001756 | |
| 0035121 | |
| 0016020 | |
| 0043434 | |
| 0005515 | |
| 0003674 | |
| 0005575 | |
| 0010003 |
| Rat chromosome position | 4q43 |
|---|
| Swiss-Prot Accession | O75581 |
|---|---|
| Q59EX8 | |
| Q9UQH4 | |
| O88572 | |
| Q3TS86 | |
| Q3US54 | |
| Q17RZ2 |
| PIR ID | JE0272 |
|---|---|
| JE0273 |
| Unigene ID | Hs.584775 |
|---|---|
| Hs.658913 | |
| Mm.321990 | |
| Rn.32960 | |
| Hs.558539 |
| KEGG ID | hsa:4040 |
|---|---|
| mmu:16974 | |
| rno:312781 |
| Swiss-Prot ID | LRP6_HUMAN |
|---|---|
| LRP6_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00000203 |
|---|---|
| IPI00271594 | |
| IPI00831041 | |
| IPI00870584 |
| Homologene ID | 1747 |
|---|
| RGD ID | 1304749 |
|---|
| MGI ID | 1298218 |
|---|
| KEGG pathway | Wnt signaling pathway |
|---|