| URN | urn:agi-llid:8313 |
|---|---|
| Total Entities | 0 |
| Connectivity | 203 |
| Name | Axin2 |
| Description | axin 2 (conductin, axil) |
| Notes | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. |
| Ariadne Ontology | AXIN |
|---|
| GO Molecular Function | beta-catenin binding |
|---|---|
| enzyme binding | |
| protein kinase binding | |
| ubiquitin protein ligase binding | |
| armadillo repeat domain binding | |
| I-SMAD binding | |
| GTPase activator activity | |
| signal transducer activity |
| GO Cellular Component | postsynaptic density |
|---|---|
| centrosome | |
| cytoplasmic microtubule | |
| protein complex | |
| beta-catenin destruction complex | |
| plasma membrane | |
| intracellular | |
| cytoplasm | |
| cell cortex | |
| cytoplasmic membrane-bounded vesicle | |
| nucleus |
| GO Biological Process | cell proliferation |
|---|---|
| cell death | |
| regulation of centromeric sister chromatid cohesion | |
| regulation of Wnt receptor signaling pathway | |
| termination of G-protein coupled receptor signaling pathway | |
| negative regulation of canonical Wnt receptor signaling pathway | |
| negative regulation of Wnt receptor signaling pathway involved in dorsal-ventral axis specification | |
| Wnt receptor signaling pathway | |
| Wnt receptor signaling pathway involved in somitogenesis | |
| regulation of mismatch repair | |
| positive regulation of GTPase activity | |
| positive regulation of protein phosphorylation | |
| positive regulation of protein kinase activity | |
| regulation of transcription, DNA-dependent | |
| negative regulation of cell proliferation | |
| negative regulation of osteoblast differentiation | |
| negative regulation of catenin import into nucleus | |
| positive regulation of cell death | |
| positive regulation of epithelial to mesenchymal transition | |
| regulation of catenin import into nucleus | |
| regulation of chondrocyte development | |
| chondrocyte differentiation involved in endochondral bone morphogenesis | |
| maintenance of DNA repeat elements | |
| cellular response to organic cyclic compound | |
| cellular protein localization | |
| mRNA stabilization | |
| multicellular organismal development | |
| somitogenesis | |
| bone mineralization | |
| dorsal-ventral axis specification | |
| odontogenesis | |
| intramembranous ossification |
| Pathway | Canonical WNT Signaling Expression Targets |
|---|---|
| WNT1 Expression Targets | |
| WNT7B Expression Targets | |
| Wnt signaling, canonical pathway | |
| altered Wnt signaling, canonical pathway | |
| canonical Wnt signaling pathway | |
| colorectal cancer pathway | |
| colorectal cancer pathway | |
| Wnt signaling, canonical pathway |
| Group | AXIN |
|---|---|
| cell proliferation | |
| cell death | |
| regulation of centromeric sister chromatid cohesion | |
| regulation of Wnt receptor signaling pathway | |
| termination of G-protein coupled receptor signaling pathway | |
| negative regulation of canonical Wnt receptor signaling pathway | |
| negative regulation of Wnt receptor signaling pathway involved in dorsal-ventral axis specification | |
| Wnt receptor signaling pathway | |
| Wnt receptor signaling pathway involved in somitogenesis | |
| regulation of mismatch repair | |
| positive regulation of GTPase activity | |
| positive regulation of protein phosphorylation | |
| positive regulation of protein kinase activity | |
| regulation of transcription, DNA-dependent | |
| negative regulation of cell proliferation | |
| negative regulation of osteoblast differentiation | |
| negative regulation of catenin import into nucleus | |
| positive regulation of cell death | |
| positive regulation of epithelial to mesenchymal transition | |
| regulation of catenin import into nucleus | |
| regulation of chondrocyte development | |
| chondrocyte differentiation involved in endochondral bone morphogenesis | |
| maintenance of DNA repeat elements | |
| cellular response to organic cyclic compound | |
| cellular protein localization | |
| mRNA stabilization | |
| multicellular organismal development | |
| somitogenesis | |
| bone mineralization | |
| dorsal-ventral axis specification | |
| odontogenesis | |
| intramembranous ossification | |
| beta-catenin binding | |
| enzyme binding | |
| protein kinase binding | |
| ubiquitin protein ligase binding | |
| armadillo repeat domain binding | |
| I-SMAD binding | |
| GTPase activator activity | |
| signal transducer activity | |
| postsynaptic density | |
| centrosome | |
| cytoplasmic microtubule | |
| protein complex | |
| beta-catenin destruction complex | |
| plasma membrane | |
| intracellular | |
| cytoplasm | |
| cell cortex | |
| cytoplasmic membrane-bounded vesicle | |
| nucleus |
| MedScan ID | 8313 |
|---|
| Hugo ID | 904 |
|---|
| Human chromosome position | 17q23-q24 |
|---|
| LocusLink ID | 8313 |
|---|---|
| 12006 | |
| 29134 |
| Alias | AXIL |
|---|---|
| axin-2 | |
| conductin | |
| axin-like protein | |
| axis inhibition protein 2 | |
| Axi1 | |
| RP23-202G21.3 | |
| Axis inhibiting protein II | |
| OTTMUSP00000003134 | |
| OTTMUSP00000003133 | |
| MGC126582 | |
| MGC10366 | |
| DKFZp781b0869 | |
| Axis inhibition protein II | |
| Axi I | |
| axin-like | |
| axin IIs | |
| axin II | |
| axin 2 (conductin, axil) | |
| axin 2 | |
| Axis inhibiting protein 2 | |
| axin2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 604025 |
|---|---|
| 114500 | |
| 608615 |
| Unigene ID | Hs.156527 |
|---|---|
| Mm.71710 | |
| Rn.162212 |
| KEGG ID | hsa:8313 |
|---|---|
| mmu:12006 | |
| rno:29134 |
| Swiss-Prot Accession | Q9Y2T1 |
|---|---|
| O88566 | |
| Q3UQK5 | |
| O70240 | |
| Q3MJ88 | |
| Q9H3M6 | |
| Q9UH84 | |
| Q6PFZ9 | |
| Q9QXJ6 | |
| Q5H9R8 | |
| Q9BRF5 |
| GO ID | 0005096 |
|---|---|
| 0070411 | |
| 0070016 | |
| 0008013 | |
| 0019899 | |
| 0019901 | |
| 0004871 | |
| 0031625 | |
| 0090244 | |
| 0030282 | |
| 0008219 | |
| 0008283 | |
| 0034613 | |
| 0071407 | |
| 0003413 | |
| 0009950 | |
| 0001957 | |
| 0048255 | |
| 0043570 | |
| 2000054 | |
| 0090090 | |
| 0035414 | |
| 0008285 | |
| 0045668 | |
| 0042476 | |
| 0043547 | |
| 0010942 | |
| 0010718 | |
| 0045860 | |
| 0001934 | |
| 0070602 | |
| 0061181 | |
| 0032423 | |
| 0038032 | |
| 0005938 | |
| 0005813 | |
| 0005737 | |
| 0016023 | |
| 0005881 | |
| 0005634 | |
| 0005886 | |
| 0014069 | |
| 0016055 | |
| 0007275 | |
| 0030111 | |
| 0001756 | |
| 0005622 | |
| 0043234 | |
| 0035412 | |
| 0030877 | |
| 0034747 | |
| 0006355 | |
| 0030178 | |
| 0007165 | |
| 0005515 | |
| 0007049 | |
| 0045786 | |
| 0005575 |
| PIR ID | T08423 |
|---|
| Swiss-Prot ID | AXIN2_HUMAN |
|---|---|
| AXIN2_RAT | |
| AXIN2_MOUSE | |
| AXN2_RAT | |
| AXN2_HUMAN | |
| Q6PFZ9_MOUSE | |
| Q3UQK5_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00294274 |
|---|---|
| IPI00196619 | |
| IPI00131981 | |
| IPI00420883 | |
| IPI00386615 | |
| IPI00788621 | |
| IPI00649284 | |
| IPI00649598 | |
| IPI00649875 | |
| IPI00648056 |
| Mouse chromosome position | 11 70.0 cM |
|---|
| Rat chromosome position | 10q32.1 |
|---|
| Homologene ID | 3420 |
|---|
| MGI ID | 1270862 |
|---|
| RGD ID | 69259 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|